ko pathway ratio_in_study ratio_in_pop p_value ko04070 Phosphatidylinositol signaling system 25/508 112/7206 1.64021617026e-07 ko04710 Circadian rhythm 14/508 43/7206 7.30333817728e-07 ko00120 Primary bile acid biosynthesis 9/508 20/7206 3.33459906317e-06 ko04020 Calcium signaling pathway 37/508 265/7206 6.61949440243e-05 ko04724 Glutamatergic synapse 24/508 152/7206 0.000156538950217 ko00564 Glycerophospholipid metabolism 18/508 99/7206 0.000160598496268 ko04921 Oxytocin signaling pathway 30/508 209/7206 0.000160989603401 ko04925 Aldosterone synthesis and secretion 18/508 105/7206 0.000344432869643 ko00140 Steroid hormone biosynthesis 10/508 41/7206 0.000423799955156 ko03040 Spliceosome 1/508 145/7206 0.000455829963912 ko04110 Cell cycle 1/508 145/7206 0.000455829963912 ko03010 Ribosome 1/508 129/7206 0.00144990725941 ko04713 Circadian entrainment 20/508 136/7206 0.00177109336058 ko00010 Glycolysis / Gluconeogenesis 13/508 74/7206 0.00177728291654 ko04726 Serotonergic synapse 20/508 137/7206 0.00186011076188 ko00051 Fructose and mannose metabolism 9/508 42/7206 0.00218823220656 ko04922 Glucagon signaling pathway 19/508 128/7206 0.0023494932434 ko05200 Pathways in cancer 19/508 492/7206 0.0033223953876 ko04976 Bile secretion 13/508 80/7206 0.00363271486252 ko00561 Glycerolipid metabolism 11/508 63/7206 0.0041188235338 ko04745 Phototransduction - fly 8/508 38/7206 0.00428320224726 ko04720 Long-term potentiation 15/508 99/7206 0.00439560926872 ko04080 Neuroactive ligand-receptor interaction 45/508 423/7206 0.00443838079991 ko05031 Amphetamine addiction 14/508 91/7206 0.00556382090373 ko00030 Pentose phosphate pathway 7/508 32/7206 0.00594114382176 ko04072 Phospholipase D signaling pathway 24/508 197/7206 0.00709932476386 ko00680 Methane metabolism 7/508 34/7206 0.00840403116508 ko00562 Inositol phosphate metabolism 13/508 89/7206 0.0105185983947 ko04725 Cholinergic synapse 20/508 160/7206 0.0114080252925 ko05032 Morphine addiction 15/508 110/7206 0.0127988149574 ko05230 Central carbon metabolism in cancer 12/508 81/7206 0.0133069194695 ko03013 RNA transport 4/508 166/7206 0.0133640809747 ko03015 mRNA surveillance pathway 1/508 93/7206 0.0139670922765 ko04137 Mitophagy - animal 12/508 82/7206 0.0141843307507 ko01230 Biosynthesis of amino acids 12/508 85/7206 0.017381055423 ko04111 Cell cycle - yeast 1/508 90/7206 0.0204968904713 ko04024 cAMP signaling pathway 30/508 279/7206 0.0224214066988 ko04960 Aldosterone-regulated sodium reabsorption 7/508 41/7206 0.0229658288149 ko05224 Breast cancer 5/508 174/7206 0.0241172698005 ko05166 HTLV-I infection 11/508 292/7206 0.02567083932 ko04971 Gastric acid secretion 13/508 98/7206 0.0258095587426 ko00350 Tyrosine metabolism 6/508 33/7206 0.0258165635283 ko00052 Galactose metabolism 6/508 33/7206 0.0258165635283 ko04911 Insulin secretion 15/508 117/7206 0.0260243438399 ko00643 Styrene degradation 2/508 4/7206 0.0270500474334 ko01040 Biosynthesis of unsaturated fatty acids 5/508 25/7206 0.0279525353774 ko04919 Thyroid hormone signaling pathway 17/508 143/7206 0.0305084583787 ko04657 IL-17 signaling pathway 1/508 87/7206 0.0311179928183 ko04068 FoxO signaling pathway 19/508 167/7206 0.0322793984969 ko04966 Collecting duct acid secretion 5/508 26/7206 0.0326689517056 ko04626 Plant-pathogen interaction 4/508 18/7206 0.0338185808281 ko04727 GABAergic synapse 14/508 110/7206 0.0355073394807 ko05169 Epstein-Barr virus infection 7/508 206/7206 0.0372395410183 ko05014 Amyotrophic lateral sclerosis (ALS) 10/508 74/7206 0.0381873068338 ko05231 Choline metabolism in cancer 16/508 134/7206 0.0382540863908 ko04510 Focal adhesion 9/508 240/7206 0.0398165821911 ko00592 alpha-Linolenic acid metabolism 4/508 19/7206 0.0405250148132 ko05203 Viral carcinogenesis 11/508 277/7206 0.0411583277129 ko04970 Salivary secretion 12/508 95/7206 0.0417137306714 ko05130 Pathogenic Escherichia coli infection 1/508 77/7206 0.0424435925596 ko00982 Drug metabolism - cytochrome P450 6/508 37/7206 0.0427976112258 ko03008 Ribosome biogenesis in eukaryotes 1/508 79/7206 0.0431415967183 ko04520 Adherens junction 2/508 103/7206 0.0486074559278 ko04964 Proximal tubule bicarbonate reclamation 5/508 29/7206 0.0496500697907