ko pathway ratio_in_study ratio_in_pop p_value ko04260 Cardiac muscle contraction 31/351 98/7206 9.11401979073e-18 ko05410 Hypertrophic cardiomyopathy (HCM) 31/351 100/7206 1.75952362632e-17 ko05414 Dilated cardiomyopathy 30/351 112/7206 5.17565013885e-15 ko04512 ECM-receptor interaction 25/351 79/7206 1.50476574886e-14 ko01200 Carbon metabolism 28/351 128/7206 9.79959083792e-12 ko04510 Focal adhesion 39/351 240/7206 1.52247643111e-11 ko04974 Protein digestion and absorption 24/351 96/7206 1.53602322669e-11 ko00020 Citrate cycle (TCA cycle) 15/351 35/7206 2.0489408252e-11 ko04261 Adrenergic signaling in cardiomyocytes 33/351 205/7206 8.01191470463e-10 ko00010 Glycolysis / Gluconeogenesis 19/351 74/7206 1.3127416516e-09 ko05010 Alzheimer's disease 32/351 202/7206 2.22139594025e-09 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 19/351 79/7206 4.32829596071e-09 ko05012 Parkinson's disease 25/351 155/7206 9.51150468697e-08 ko00190 Oxidative phosphorylation 22/351 127/7206 1.5760895382e-07 ko00620 Pyruvate metabolism 13/351 46/7206 1.64229168974e-07 ko04020 Calcium signaling pathway 33/351 265/7206 4.97901681854e-07 ko05016 Huntington's disease 27/351 215/7206 4.84802672706e-06 ko05416 Viral myocarditis 12/351 55/7206 9.71475036708e-06 ko00710 Carbon fixation in photosynthetic organisms 8/351 27/7206 2.87354873314e-05 ko04922 Glucagon signaling pathway 18/351 128/7206 4.27624795373e-05 ko01230 Biosynthesis of amino acids 14/351 85/7206 5.29607881102e-05 ko04022 cGMP-PKG signaling pathway 25/351 216/7206 6.23911987413e-05 ko04921 Oxytocin signaling pathway 24/351 209/7206 9.75550962882e-05 ko04964 Proximal tubule bicarbonate reclamation 7/351 29/7206 0.000376997626143 ko04932 Non-alcoholic fatty liver disease (NAFLD) 20/351 182/7206 0.000617210061629 ko04062 Chemokine signaling pathway 1/351 201/7206 0.000728913961496 ko04151 PI3K-Akt signaling pathway 34/351 390/7206 0.000933488970671 ko00500 Starch and sucrose metabolism 7/351 35/7206 0.00126225449459 ko04060 Cytokine-cytokine receptor interaction 1/351 191/7206 0.00165627115805 ko04371 Apelin signaling pathway 18/351 177/7206 0.00369184831195 ko05203 Viral carcinogenesis 4/351 277/7206 0.00392994901234 ko00030 Pentose phosphate pathway 6/351 32/7206 0.00395033267437 ko03013 RNA transport 1/351 166/7206 0.00507708180405 ko00680 Methane metabolism 6/351 34/7206 0.00540180768308 ko00640 Propanoate metabolism 6/351 34/7206 0.00540180768308 ko04072 Phospholipase D signaling pathway 2/351 197/7206 0.00630920755019 ko04724 Glutamatergic synapse 1/351 152/7206 0.00703209800859 ko05322 Systemic lupus erythematosus 1/351 151/7206 0.00703841354402 ko05146 Amoebiasis 11/351 99/7206 0.00843173560993 ko00250 Alanine, aspartate and glutamate metabolism 6/351 38/7206 0.00941795706635 ko04144 Endocytosis 7/351 342/7206 0.00954424922171 ko04014 Ras signaling pathway 5/351 279/7206 0.0101885888842 ko04110 Cell cycle 1/351 145/7206 0.0102270387119 ko04152 AMPK signaling pathway 15/351 161/7206 0.0143955699798 ko01210 2-Oxocarboxylic acid metabolism 4/351 20/7206 0.0144185680258 ko00280 Valine, leucine and isoleucine degradation 7/351 54/7206 0.0150791255729 ko00071 Fatty acid degradation 6/351 45/7206 0.0209167487861 ko05142 Chagas disease (American trypanosomiasis) 1/351 130/7206 0.0215705524436 ko04071 Sphingolipid signaling pathway 2/351 162/7206 0.0248890759156 ko04140 Autophagy - animal 2/351 164/7206 0.025274550853 ko04550 Signaling pathways regulating pluripotency of stem cells 2/351 165/7206 0.0255368613745 ko01212 Fatty acid metabolism 7/351 60/7206 0.0256894988207 ko05167 Kaposi's sarcoma-associated herpesvirus infection 3/351 191/7206 0.0258940605326 ko00220 Arginine biosynthesis 4/351 24/7206 0.027149758304 ko04971 Gastric acid secretion 10/351 98/7206 0.0277149176603 ko01522 Endocrine resistance 1/351 124/7206 0.0317716308355 ko00630 Glyoxylate and dicarboxylate metabolism 5/351 38/7206 0.0356943344387 ko04150 mTOR signaling pathway 3/351 184/7206 0.0357426760245 ko05152 Tuberculosis 3/351 187/7206 0.0363823378838 ko04920 Adipocytokine signaling pathway 9/351 89/7206 0.0400241035873 ko04530 Tight junction 18/351 228/7206 0.040437770668 ko00720 Carbon fixation pathways in prokaryotes 3/351 17/7206 0.0468915006126 ko03040 Spliceosome 2/351 145/7206 0.0487530341418