ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	203/1352	423/7206	1.74746445928e-45
ko04724	Glutamatergic synapse	89/1352	152/7206	3.76782917426e-28
ko05033	Nicotine addiction	46/1352	56/7206	9.87621507699e-25
ko05032	Morphine addiction	67/1352	110/7206	8.43659170757e-23
ko04713	Circadian entrainment	74/1352	136/7206	6.20652355271e-21
ko04727	GABAergic synapse	63/1352	110/7206	1.54389473624e-19
ko04020	Calcium signaling pathway	111/1352	265/7206	8.73651792414e-19
ko04728	Dopaminergic synapse	85/1352	185/7206	1.05049133726e-17
ko04721	Synaptic vesicle cycle	48/1352	80/7206	2.6676727982e-16
ko04024	cAMP signaling pathway	106/1352	279/7206	2.27663109963e-14
ko04725	Cholinergic synapse	71/1352	160/7206	5.29186918238e-14
ko04723	Retrograde endocannabinoid signaling	75/1352	175/7206	9.41635807531e-14
ko04726	Serotonergic synapse	63/1352	137/7206	1.89138701698e-13
ko04742	Taste transduction	35/1352	61/7206	1.88047942155e-11
ko04921	Oxytocin signaling pathway	80/1352	209/7206	2.78624054547e-11
ko03010	Ribosome	1/1352	129/7206	1.27207092383e-10
ko04911	Insulin secretion	52/1352	117/7206	1.43381160524e-10
ko04744	Phototransduction	24/1352	36/7206	3.68765073451e-10
ko05031	Amphetamine addiction	42/1352	91/7206	1.83254836856e-09
ko03040	Spliceosome	4/1352	145/7206	8.34610418655e-09
ko04970	Salivary secretion	42/1352	95/7206	1.13904769718e-08
ko04022	cGMP-PKG signaling pathway	74/1352	216/7206	4.04562934869e-08
ko05322	Systemic lupus erythematosus	6/1352	151/7206	7.75140438501e-08
ko04925	Aldosterone synthesis and secretion	43/1352	105/7206	1.00718477411e-07
ko04261	Adrenergic signaling in cardiomyocytes	70/1352	205/7206	1.41224198641e-07
ko04720	Long-term potentiation	41/1352	99/7206	1.52590847745e-07
ko05203	Viral carcinogenesis	21/1352	277/7206	1.57690194454e-07
ko03013	RNA transport	8/1352	166/7206	1.7264794817e-07
ko04110	Cell cycle	7/1352	145/7206	1.40558142518e-06
ko05030	Cocaine addiction	31/1352	73/7206	2.54699322266e-06
ko04971	Gastric acid secretion	38/1352	98/7206	2.95440919342e-06
ko04070	Phosphatidylinositol signaling system	41/1352	112/7206	7.29029661747e-06
ko04966	Collecting duct acid secretion	15/1352	26/7206	1.11817163388e-05
ko05168	Herpes simplex infection	13/1352	182/7206	1.17334493643e-05
ko04972	Pancreatic secretion	40/1352	111/7206	2.07215097552e-05
ko04141	Protein processing in endoplasmic reticulum	14/1352	184/7206	2.18837961436e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1352	79/7206	2.88959099985e-05
ko04976	Bile secretion	31/1352	80/7206	3.23316718157e-05
ko04120	Ubiquitin mediated proteolysis	9/1352	138/7206	5.87968382294e-05
ko05164	Influenza A	13/1352	167/7206	7.95983641177e-05
ko05161	Hepatitis B	14/1352	173/7206	0.000104745997044
ko04730	Long-term depression	29/1352	78/7206	0.000111743999014
ko04621	NOD-like receptor signaling pathway	12/1352	157/7206	0.000112454159938
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1352	74/7206	0.000120595518911
ko05169	Epstein-Barr virus infection	19/1352	206/7206	0.000183676589302
ko00520	Amino sugar and nucleotide sugar metabolism	1/1352	55/7206	0.000205347370546
ko04745	Phototransduction - fly	17/1352	38/7206	0.000210209578597
ko04740	Olfactory transduction	29/1352	80/7206	0.000230095761562
ko00120	Primary bile acid biosynthesis	11/1352	20/7206	0.000308434280488
ko04750	Inflammatory mediator regulation of TRP channels	39/1352	122/7206	0.000395919961345
ko04924	Renin secretion	30/1352	86/7206	0.000397833860585
ko04060	Cytokine-cytokine receptor interaction	18/1352	191/7206	0.000464152304237
ko04330	Notch signaling pathway	2/1352	62/7206	0.000468040718868
ko04710	Circadian rhythm	18/1352	43/7206	0.000507583993232
ko04371	Apelin signaling pathway	52/1352	177/7206	0.000579772041068
ko05205	Proteoglycans in cancer	30/1352	271/7206	0.000615066190668
ko04270	Vascular smooth muscle contraction	46/1352	154/7206	0.000760391176857
ko05162	Measles	9/1352	120/7206	0.000836025759499
ko04010	MAPK signaling pathway	84/1352	321/7206	0.0009492496439
ko05166	HTLV-I infection	34/1352	292/7206	0.0009745336813
ko04964	Proximal tubule bicarbonate reclamation	13/1352	29/7206	0.00114002035881
ko05219	Bladder cancer	1/1352	48/7206	0.00116085786882
ko04922	Glucagon signaling pathway	39/1352	128/7206	0.00125175595226
ko04072	Phospholipase D signaling pathway	55/1352	197/7206	0.00154848803396
ko03022	Basal transcription factors	1/1352	44/7206	0.00169758886947
ko03420	Nucleotide excision repair	1/1352	46/7206	0.00179497252961
ko04214	Apoptosis - fly	4/1352	72/7206	0.00210235587893
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1352	79/7206	0.00220986349096
ko05200	Pathways in cancer	67/1352	492/7206	0.0022308717553
ko04260	Cardiac muscle contraction	31/1352	98/7206	0.00240500137215
ko04622	RIG-I-like receptor signaling pathway	3/1352	62/7206	0.00277621442112
ko05110	Vibrio cholerae infection	22/1352	63/7206	0.00292276413446
ko04915	Estrogen signaling pathway	38/1352	131/7206	0.00442037754019
ko04923	Regulation of lipolysis in adipocytes	25/1352	77/7206	0.00466688931605
ko04014	Ras signaling pathway	71/1352	279/7206	0.00476994299088
ko04540	Gap junction	37/1352	128/7206	0.00571237179179
ko03410	Base excision repair	1/1352	38/7206	0.00591005805961
ko05131	Shigellosis	6/1352	82/7206	0.00623864895005
ko04514	Cell adhesion molecules (CAMs)	37/1352	130/7206	0.00626767070225
ko05215	Prostate cancer	10/1352	111/7206	0.00661219000964
ko04630	Jak-STAT signaling pathway	13/1352	132/7206	0.00662741347037
ko05414	Dilated cardiomyopathy	33/1352	112/7206	0.0067759008958
ko04657	IL-17 signaling pathway	7/1352	87/7206	0.00811025892254
ko05133	Pertussis	7/1352	87/7206	0.00811025892254
ko05416	Viral myocarditis	3/1352	55/7206	0.00837282346642
ko04217	Necroptosis	20/1352	178/7206	0.00838375117706
ko05150	Staphylococcus aureus infection	1/1352	36/7206	0.00897608815612
ko04626	Plant-pathogen interaction	8/1352	18/7206	0.0110113644934
ko05220	Chronic myeloid leukemia	7/1352	85/7206	0.0111287129755
ko04510	Focal adhesion	30/1352	240/7206	0.0113772711763
ko02010	ABC transporters	14/1352	39/7206	0.0116309642844
ko05130	Pathogenic Escherichia coli infection	6/1352	77/7206	0.0117567765382
ko04210	Apoptosis	21/1352	180/7206	0.0117930196266
ko04930	Type II diabetes mellitus	18/1352	54/7206	0.012737830762
ko00362	Benzoate degradation	4/1352	6/7206	0.0134064391117
ko05206	MicroRNAs in cancer	21/1352	177/7206	0.0148299926964
ko04550	Signaling pathways regulating pluripotency of stem cells	19/1352	165/7206	0.0151133419989
ko05212	Pancreatic cancer	7/1352	83/7206	0.0152364540296
ko04350	TGF-beta signaling pathway	10/1352	103/7206	0.0153920327733
ko05140	Leishmaniasis	6/1352	75/7206	0.0162568776199
ko04658	Th1 and Th2 cell differentiation	9/1352	96/7206	0.0170782190126
ko04064	NF-kappa B signaling pathway	9/1352	96/7206	0.0170782190126
ko05202	Transcriptional misregulation in cancer	23/1352	188/7206	0.0179496039136
ko00562	Inositol phosphate metabolism	26/1352	89/7206	0.0191334851313
ko04620	Toll-like receptor signaling pathway	10/1352	100/7206	0.0203155255181
ko04711	Circadian rhythm - fly	6/1352	13/7206	0.0222072642194
ko00965	Betalain biosynthesis	3/1352	4/7206	0.0226667252048
ko04360	Axon guidance	57/1352	233/7206	0.0264958167098
ko04142	Lysosome	18/1352	151/7206	0.0270426269523
ko04612	Antigen processing and presentation	7/1352	77/7206	0.0271635144644
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1352	100/7206	0.0272408649926
ko05145	Toxoplasmosis	14/1352	126/7206	0.0279933835413
ko04113	Meiosis - yeast	6/1352	70/7206	0.0298943008737
ko04218	Cellular senescence	22/1352	177/7206	0.0314211313983
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1352	14/7206	0.032822402234
ko03018	RNA degradation	8/1352	84/7206	0.0336057440455
ko04672	Intestinal immune network for IgA production	2/1352	37/7206	0.0340718180066
ko05144	Malaria	3/1352	45/7206	0.0346189245625
ko00240	Pyrimidine metabolism	12/1352	110/7206	0.0356159872276
ko04115	p53 signaling pathway	7/1352	74/7206	0.0363978930551
ko05222	Small cell lung cancer	9/1352	89/7206	0.0392666703064
ko05217	Basal cell carcinoma	6/1352	68/7206	0.0407271628442
ko04520	Adherens junction	11/1352	103/7206	0.0407661293551
ko04960	Aldosterone-regulated sodium reabsorption	13/1352	41/7206	0.0431871301554
ko04810	Regulation of actin cytoskeleton	37/1352	264/7206	0.0445833504074
ko00650	Butanoate metabolism	9/1352	26/7206	0.0456042389382
ko04974	Protein digestion and absorption	26/1352	96/7206	0.0470915487655