ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	186/1137	423/7206	2.2537483139e-46
ko04724	Glutamatergic synapse	84/1137	152/7206	1.00484467542e-29
ko05033	Nicotine addiction	44/1137	56/7206	2.04413544202e-25
ko05032	Morphine addiction	63/1137	110/7206	1.12257983068e-23
ko04713	Circadian entrainment	71/1137	136/7206	2.79196459998e-23
ko04727	GABAergic synapse	61/1137	110/7206	5.9129935241e-22
ko04721	Synaptic vesicle cycle	50/1137	80/7206	2.22532331715e-21
ko04728	Dopaminergic synapse	81/1137	185/7206	4.14398538933e-20
ko04725	Cholinergic synapse	73/1137	160/7206	1.77233685168e-19
ko04723	Retrograde endocannabinoid signaling	73/1137	175/7206	8.31050837483e-17
ko04020	Calcium signaling pathway	96/1137	265/7206	9.68538309889e-17
ko04024	cAMP signaling pathway	96/1137	279/7206	6.464873687e-15
ko04911	Insulin secretion	53/1137	117/7206	2.65619631758e-14
ko04921	Oxytocin signaling pathway	76/1137	209/7206	1.39051418612e-13
ko04726	Serotonergic synapse	55/1137	137/7206	3.79607113398e-12
ko04742	Taste transduction	33/1137	61/7206	4.7925486581e-12
ko05031	Amphetamine addiction	41/1137	91/7206	2.90381846066e-11
ko04744	Phototransduction	23/1137	36/7206	8.51004868377e-11
ko03040	Spliceosome	1/1137	145/7206	5.16597985884e-10
ko04360	Axon guidance	73/1137	233/7206	1.43575815889e-09
ko04261	Adrenergic signaling in cardiomyocytes	66/1137	205/7206	2.59260746234e-09
ko04720	Long-term potentiation	40/1137	99/7206	2.7447904127e-09
ko05322	Systemic lupus erythematosus	3/1137	151/7206	2.74442665529e-08
ko04925	Aldosterone synthesis and secretion	40/1137	105/7206	3.30640076394e-08
ko03013	RNA transport	5/1137	166/7206	1.35207741528e-07
ko04970	Salivary secretion	36/1137	95/7206	1.94254880164e-07
ko04022	cGMP-PKG signaling pathway	63/1137	216/7206	5.34535006025e-07
ko04010	MAPK signaling pathway	84/1137	321/7206	9.59175798467e-07
ko05030	Cocaine addiction	28/1137	73/7206	2.30723764747e-06
ko04014	Ras signaling pathway	74/1137	279/7206	3.17724463626e-06
ko04971	Gastric acid secretion	34/1137	98/7206	3.74942802489e-06
ko04070	Phosphatidylinositol signaling system	37/1137	112/7206	4.98755753527e-06
ko04740	Olfactory transduction	29/1137	80/7206	6.74960820671e-06
ko04514	Cell adhesion molecules (CAMs)	41/1137	130/7206	7.58364762111e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1137	74/7206	1.32819725391e-05
ko04141	Protein processing in endoplasmic reticulum	10/1137	184/7206	2.09971749795e-05
ko05203	Viral carcinogenesis	20/1137	277/7206	2.23546840127e-05
ko04750	Inflammatory mediator regulation of TRP channels	38/1137	122/7206	2.34875249609e-05
ko04072	Phospholipase D signaling pathway	54/1137	197/7206	2.5036215824e-05
ko05168	Herpes simplex infection	10/1137	182/7206	2.9685117862e-05
ko04972	Pancreatic secretion	35/1137	111/7206	3.10820698926e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1137	79/7206	3.25444518267e-05
ko04966	Collecting duct acid secretion	13/1137	26/7206	4.85586554302e-05
ko05164	Influenza A	9/1137	167/7206	5.59089225032e-05
ko04745	Phototransduction - fly	16/1137	38/7206	9.34493525063e-05
ko04120	Ubiquitin mediated proteolysis	7/1137	138/7206	0.000136611804184
ko04060	Cytokine-cytokine receptor interaction	13/1137	191/7206	0.000256300068916
ko04146	Peroxisome	3/1137	89/7206	0.000349914470067
ko04730	Long-term depression	25/1137	78/7206	0.000423507592573
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1137	79/7206	0.000461041117326
ko04621	NOD-like receptor signaling pathway	10/1137	157/7206	0.000525694886657
ko05110	Vibrio cholerae infection	21/1137	63/7206	0.00066840067483
ko04371	Apelin signaling pathway	45/1137	177/7206	0.000767249988029
ko04924	Renin secretion	26/1137	86/7206	0.000825762648846
ko04915	Estrogen signaling pathway	35/1137	131/7206	0.00145636738641
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1137	59/7206	0.00171940750087
ko04540	Gap junction	34/1137	128/7206	0.00197195508962
ko00280	Valine, leucine and isoleucine degradation	1/1137	54/7206	0.00208296846413
ko04710	Circadian rhythm	15/1137	43/7206	0.00224031431414
ko04612	Antigen processing and presentation	3/1137	77/7206	0.00233883251452
ko05414	Dilated cardiomyopathy	30/1137	112/7206	0.00245014708691
ko04260	Cardiac muscle contraction	27/1137	98/7206	0.00296404972208
ko04930	Type II diabetes mellitus	17/1137	54/7206	0.00393559658053
ko00330	Arginine and proline metabolism	2/1137	61/7206	0.00405201525642
ko04973	Carbohydrate digestion and absorption	14/1137	42/7206	0.00446267657613
ko05219	Bladder cancer	1/1137	48/7206	0.00456630590088
ko04610	Complement and coagulation cascades	4/1137	79/7206	0.00498105935663
ko04110	Cell cycle	11/1137	145/7206	0.00535269398688
ko04015	Rap1 signaling pathway	61/1137	278/7206	0.00551316976979
ko05205	Proteoglycans in cancer	27/1137	271/7206	0.0063979647238
ko00071	Fatty acid degradation	1/1137	45/7206	0.00680510854519
ko03420	Nucleotide excision repair	1/1137	46/7206	0.00696868479933
ko04064	NF-kappa B signaling pathway	6/1137	96/7206	0.00700802650418
ko04976	Bile secretion	22/1137	80/7206	0.00780255569571
ko04960	Aldosterone-regulated sodium reabsorption	13/1137	41/7206	0.00907707409232
ko04711	Circadian rhythm - fly	6/1137	13/7206	0.0096182974464
ko05140	Leishmaniasis	4/1137	75/7206	0.00994693842042
ko03022	Basal transcription factors	1/1137	44/7206	0.0107364915802
ko00240	Pyrimidine metabolism	8/1137	110/7206	0.0116689605747
ko00562	Inositol phosphate metabolism	23/1137	89/7206	0.0124824666814
ko04622	RIG-I-like receptor signaling pathway	3/1137	62/7206	0.0134658762423
ko04922	Glucagon signaling pathway	31/1137	128/7206	0.0136580427222
ko05131	Shigellosis	5/1137	82/7206	0.0137676464013
ko00310	Lysine degradation	4/1137	73/7206	0.0141743862393
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1137	14/7206	0.0146198340652
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1137	40/7206	0.0152383372201
ko04626	Plant-pathogen interaction	7/1137	18/7206	0.0153680009601
ko04964	Proximal tubule bicarbonate reclamation	10/1137	29/7206	0.0172362451658
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1137	100/7206	0.0177561648673
ko04657	IL-17 signaling pathway	6/1137	87/7206	0.0178003392874
ko05133	Pertussis	6/1137	87/7206	0.0178003392874
ko00380	Tryptophan metabolism	2/1137	50/7206	0.0180371800967
ko04923	Regulation of lipolysis in adipocytes	20/1137	77/7206	0.0181128083191
ko03320	PPAR signaling pathway	4/1137	69/7206	0.0192294233128
ko04916	Melanogenesis	33/1137	142/7206	0.0193655605685
ko05016	Huntington's disease	22/1137	215/7206	0.0223785422706
ko05162	Measles	10/1137	120/7206	0.0224693675264
ko00982	Drug metabolism - cytochrome P450	1/1137	37/7206	0.0226317476075
ko05231	Choline metabolism in cancer	31/1137	134/7206	0.0227363149006
ko03410	Base excision repair	1/1137	38/7206	0.0230517957613
ko04912	GnRH signaling pathway	29/1137	122/7206	0.0231420798536
ko05169	Epstein-Barr virus infection	21/1137	206/7206	0.0253531322396
ko05145	Toxoplasmosis	11/1137	126/7206	0.0262138853032
ko00260	Glycine, serine and threonine metabolism	2/1137	48/7206	0.0264860011532
ko05161	Hepatitis B	17/1137	173/7206	0.0267344473434
ko04722	Neurotrophin signaling pathway	36/1137	160/7206	0.0274773346516
ko05214	Glioma	20/1137	79/7206	0.0282755804734
ko03018	RNA degradation	6/1137	84/7206	0.0333563108647
ko00640	Propanoate metabolism	1/1137	34/7206	0.0336667921212
ko04270	Vascular smooth muscle contraction	34/1137	154/7206	0.0338236049016
ko04214	Apoptosis - fly	5/1137	72/7206	0.0348218654974
ko04213	Longevity regulating pathway - multiple species	21/1137	86/7206	0.0359121176916
ko00512	Mucin type O-glycan biosynthesis	9/1137	29/7206	0.0366813331339
ko04217	Necroptosis	18/1137	178/7206	0.0368183249604
ko04216	Ferroptosis	2/1137	44/7206	0.0372859078416
ko00480	Glutathione metabolism	3/1137	55/7206	0.0386694627563
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1137	92/7206	0.0423498419623
ko04114	Oocyte meiosis	31/1137	139/7206	0.0446841012914
ko04071	Sphingolipid signaling pathway	35/1137	162/7206	0.0489086412471
ko01200	Carbon metabolism	12/1137	128/7206	0.0493498187941
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1137	182/7206	0.0496913750887