ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04724	Glutamatergic synapse	79/833	152/7206	3.17544539176e-35
ko04080	Neuroactive ligand-receptor interaction	138/833	423/7206	4.8426399016e-33
ko05033	Nicotine addiction	44/833	56/7206	3.00359401982e-31
ko05032	Morphine addiction	61/833	110/7206	1.93085762988e-29
ko04727	GABAergic synapse	60/833	110/7206	1.93509731754e-28
ko04713	Circadian entrainment	60/833	136/7206	3.78453889021e-22
ko04723	Retrograde endocannabinoid signaling	69/833	175/7206	6.61503412773e-22
ko04728	Dopaminergic synapse	70/833	185/7206	5.325872076e-21
ko04725	Cholinergic synapse	63/833	160/7206	4.80257665741e-20
ko04024	cAMP signaling pathway	82/833	279/7206	1.40079575376e-16
ko04911	Insulin secretion	46/833	117/7206	6.57487340626e-15
ko04742	Taste transduction	31/833	61/7206	4.05086333961e-14
ko04721	Synaptic vesicle cycle	36/833	80/7206	4.38035799445e-14
ko04261	Adrenergic signaling in cardiomyocytes	61/833	205/7206	7.50033619532e-13
ko04726	Serotonergic synapse	47/833	137/7206	1.27019848448e-12
ko04744	Phototransduction	22/833	36/7206	1.45368086691e-12
ko04020	Calcium signaling pathway	68/833	265/7206	9.95559578971e-11
ko04921	Oxytocin signaling pathway	56/833	209/7206	7.52263593529e-10
ko05031	Amphetamine addiction	32/833	91/7206	2.59727961534e-09
ko05030	Cocaine addiction	28/833	73/7206	2.73097200172e-09
ko04720	Long-term potentiation	33/833	99/7206	6.92740339197e-09
ko04970	Salivary secretion	30/833	95/7206	1.33555638466e-07
ko05203	Viral carcinogenesis	8/833	277/7206	1.50848969642e-07
ko04010	MAPK signaling pathway	68/833	321/7206	4.00432072885e-07
ko03040	Spliceosome	1/833	145/7206	5.43846995533e-07
ko04514	Cell adhesion molecules (CAMs)	35/833	130/7206	1.05195615811e-06
ko04260	Cardiac muscle contraction	28/833	98/7206	3.30692392049e-06
ko04925	Aldosterone synthesis and secretion	29/833	105/7206	6.94053272666e-06
ko04022	cGMP-PKG signaling pathway	47/833	216/7206	1.2233049456e-05
ko04072	Phospholipase D signaling pathway	44/833	197/7206	1.25678919904e-05
ko04972	Pancreatic secretion	29/833	111/7206	1.63248402848e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	23/833	79/7206	1.76074615922e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	22/833	74/7206	1.85693611127e-05
ko04360	Axon guidance	49/833	233/7206	2.41032230247e-05
ko04730	Long-term depression	22/833	78/7206	4.58640169183e-05
ko05414	Dilated cardiomyopathy	28/833	112/7206	6.58051234879e-05
ko04120	Ubiquitin mediated proteolysis	3/833	138/7206	7.37836598764e-05
ko05168	Herpes simplex infection	6/833	182/7206	8.7937825038e-05
ko05322	Systemic lupus erythematosus	4/833	151/7206	9.34833137654e-05
ko04971	Gastric acid secretion	25/833	98/7206	9.4578348135e-05
ko03013	RNA transport	5/833	166/7206	0.000110890988888
ko04740	Olfactory transduction	21/833	80/7206	0.000259675359962
ko05164	Influenza A	6/833	167/7206	0.000339227318522
ko04915	Estrogen signaling pathway	29/833	131/7206	0.000462932910966
ko04060	Cytokine-cytokine receptor interaction	8/833	191/7206	0.000506942581158
ko05205	Proteoglycans in cancer	15/833	271/7206	0.000911016466803
ko03008	Ribosome biogenesis in eukaryotes	1/833	79/7206	0.00115217639076
ko04141	Protein processing in endoplasmic reticulum	9/833	184/7206	0.00227418647599
ko04110	Cell cycle	6/833	145/7206	0.00239394607968
ko05169	Epstein-Barr virus infection	11/833	206/7206	0.00272656376824
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/833	14/7206	0.00309900803854
ko04621	NOD-like receptor signaling pathway	7/833	157/7206	0.00333661155857
ko04964	Proximal tubule bicarbonate reclamation	9/833	29/7206	0.00414037573126
ko04976	Bile secretion	18/833	80/7206	0.00441296757061
ko04540	Gap junction	26/833	128/7206	0.00468415651602
ko04137	Mitophagy - animal	2/833	82/7206	0.00488176886347
ko04640	Hematopoietic cell lineage	1/833	64/7206	0.00552507149171
ko04070	Phosphatidylinositol signaling system	23/833	112/7206	0.00649335922951
ko05410	Hypertrophic cardiomyopathy (HCM)	21/833	100/7206	0.00649772101256
ko04961	Endocrine and other factor-regulated calcium reabsorption	14/833	59/7206	0.00690940156426
ko04014	Ras signaling pathway	47/833	279/7206	0.00724207512501
ko04930	Type II diabetes mellitus	13/833	54/7206	0.00853066740294
ko04371	Apelin signaling pathway	32/833	177/7206	0.00863643059862
ko05162	Measles	5/833	120/7206	0.00870226685472
ko04745	Phototransduction - fly	10/833	38/7206	0.00927426145079
ko05034	Alcoholism	41/833	238/7206	0.00950851051497
ko05140	Leishmaniasis	2/833	75/7206	0.0101236082819
ko04918	Thyroid hormone synthesis	18/833	86/7206	0.0102960522033
ko04612	Antigen processing and presentation	2/833	77/7206	0.0105653787472
ko04350	TGF-beta signaling pathway	4/833	103/7206	0.0118754674018
ko04750	Inflammatory mediator regulation of TRP channels	23/833	122/7206	0.0149985198027
ko03018	RNA degradation	3/833	84/7206	0.015661501827
ko00240	Pyrimidine metabolism	5/833	110/7206	0.0157723405246
ko00480	Glutathione metabolism	1/833	55/7206	0.0178587913549
ko04932	Non-alcoholic fatty liver disease (NAFLD)	11/833	182/7206	0.0180890900733
ko04923	Regulation of lipolysis in adipocytes	16/833	77/7206	0.0181084291896
ko05321	Inflammatory bowel disease (IBD)	1/833	56/7206	0.0183391010982
ko04630	Jak-STAT signaling pathway	7/833	132/7206	0.0191820663505
ko03320	PPAR signaling pathway	2/833	69/7206	0.021127571058
ko05131	Shigellosis	3/833	82/7206	0.0222509743588
ko04064	NF-kappa B signaling pathway	4/833	96/7206	0.0227210140521
ko04218	Cellular senescence	11/833	177/7206	0.0230755677514
ko04973	Carbohydrate digestion and absorption	10/833	42/7206	0.0245488443349
ko01200	Carbon metabolism	7/833	128/7206	0.0254398624347
ko04140	Autophagy - animal	10/833	164/7206	0.0254950586132
ko04924	Renin secretion	17/833	86/7206	0.0255289490941
ko05231	Choline metabolism in cancer	24/833	134/7206	0.0279795459669
ko04670	Leukocyte transendothelial migration	9/833	151/7206	0.0280817997259
ko04146	Peroxisome	4/833	89/7206	0.0302103443553
ko04062	Chemokine signaling pathway	33/833	201/7206	0.0333553853131
ko05133	Pertussis	4/833	87/7206	0.0414136215249
ko00330	Arginine and proline metabolism	2/833	61/7206	0.042151757925
ko00310	Lysine degradation	3/833	73/7206	0.0424091765969
ko00562	Inositol phosphate metabolism	17/833	89/7206	0.0427803710057
ko04217	Necroptosis	12/833	178/7206	0.0428920568814
ko04960	Aldosterone-regulated sodium reabsorption	9/833	41/7206	0.0475569519632