ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	206/1199	423/7206	9.8700183067e-57
ko04724	Glutamatergic synapse	91/1199	152/7206	4.79865143707e-34
ko05033	Nicotine addiction	49/1199	56/7206	2.0828804992e-31
ko04713	Circadian entrainment	79/1199	136/7206	2.13712753477e-28
ko05032	Morphine addiction	69/1199	110/7206	8.88011426163e-28
ko04727	GABAergic synapse	67/1199	110/7206	6.4782714597e-26
ko04728	Dopaminergic synapse	87/1199	185/7206	1.62545742389e-22
ko04725	Cholinergic synapse	78/1199	160/7206	1.66967099622e-21
ko04024	cAMP signaling pathway	108/1199	279/7206	2.19933617996e-19
ko04020	Calcium signaling pathway	104/1199	265/7206	2.77339364161e-19
ko04723	Retrograde endocannabinoid signaling	79/1199	175/7206	3.53105182256e-19
ko04721	Synaptic vesicle cycle	46/1199	80/7206	9.20516915342e-17
ko04911	Insulin secretion	58/1199	117/7206	1.04204612735e-16
ko04726	Serotonergic synapse	62/1199	137/7206	2.33108657029e-15
ko04921	Oxytocin signaling pathway	80/1199	209/7206	3.83738975505e-14
ko04742	Taste transduction	36/1199	61/7206	7.04400095533e-14
ko05031	Amphetamine addiction	44/1199	91/7206	1.69090734065e-12
ko04744	Phototransduction	25/1199	36/7206	2.50732564943e-12
ko04720	Long-term potentiation	46/1199	99/7206	3.16987414572e-12
ko04261	Adrenergic signaling in cardiomyocytes	74/1199	205/7206	7.13171571762e-12
ko04970	Salivary secretion	43/1199	95/7206	4.78091422984e-11
ko03040	Spliceosome	1/1199	145/7206	1.18531342373e-10
ko04925	Aldosterone synthesis and secretion	42/1199	105/7206	1.25103791844e-08
ko04360	Axon guidance	72/1199	233/7206	4.73343561869e-08
ko04971	Gastric acid secretion	39/1199	98/7206	4.88636853095e-08
ko05203	Viral carcinogenesis	16/1199	277/7206	5.77789734339e-08
ko04070	Phosphatidylinositol signaling system	41/1199	112/7206	2.58075560116e-07
ko05322	Systemic lupus erythematosus	5/1199	151/7206	3.8036787241e-07
ko04060	Cytokine-cytokine receptor interaction	9/1199	191/7206	5.58751169523e-07
ko05030	Cocaine addiction	30/1199	73/7206	5.62327020673e-07
ko04010	MAPK signaling pathway	88/1199	321/7206	7.14801875633e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1199	74/7206	7.97413215429e-07
ko03013	RNA transport	7/1199	166/7206	1.29933506917e-06
ko04022	cGMP-PKG signaling pathway	64/1199	216/7206	1.57234260263e-06
ko04740	Olfactory transduction	31/1199	80/7206	2.1138013901e-06
ko05168	Herpes simplex infection	9/1199	182/7206	2.39099663069e-06
ko04972	Pancreatic secretion	38/1199	111/7206	7.25095997565e-06
ko05164	Influenza A	9/1199	167/7206	1.30865698923e-05
ko04072	Phospholipase D signaling pathway	57/1199	197/7206	1.52043008861e-05
ko04514	Cell adhesion molecules (CAMs)	41/1199	130/7206	2.29286845478e-05
ko04014	Ras signaling pathway	73/1199	279/7206	3.69591819742e-05
ko04730	Long-term depression	28/1199	78/7206	3.90955504317e-05
ko04745	Phototransduction - fly	17/1199	38/7206	4.43024755157e-05
ko04141	Protein processing in endoplasmic reticulum	12/1199	184/7206	5.22510420433e-05
ko04540	Gap junction	39/1199	128/7206	9.72683758601e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1199	79/7206	0.000112065507923
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1199	59/7206	0.000126347489653
ko04612	Antigen processing and presentation	2/1199	77/7206	0.00016629562457
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1199	79/7206	0.000179769373607
ko04621	NOD-like receptor signaling pathway	10/1199	157/7206	0.000193185722473
ko04110	Cell cycle	9/1199	145/7206	0.000265348919764
ko04750	Inflammatory mediator regulation of TRP channels	36/1199	122/7206	0.000325747931263
ko05169	Epstein-Barr virus infection	17/1199	206/7206	0.000581851391675
ko04924	Renin secretion	27/1199	86/7206	0.000652802945639
ko04610	Complement and coagulation cascades	3/1199	79/7206	0.000696071179936
ko05414	Dilated cardiomyopathy	32/1199	112/7206	0.00128561268245
ko04260	Cardiac muscle contraction	29/1199	98/7206	0.00142228934045
ko05162	Measles	8/1199	120/7206	0.00181350038058
ko05205	Proteoglycans in cancer	28/1199	271/7206	0.00351804441204
ko04976	Bile secretion	24/1199	80/7206	0.00354860881457
ko04146	Peroxisome	5/1199	89/7206	0.00366161787066
ko05144	Malaria	1/1199	45/7206	0.00434857450098
ko00071	Fatty acid degradation	1/1199	45/7206	0.00434857450098
ko03420	Nucleotide excision repair	1/1199	46/7206	0.0044317761631
ko05231	Choline metabolism in cancer	35/1199	134/7206	0.00470751563835
ko04015	Rap1 signaling pathway	64/1199	278/7206	0.00509044292284
ko00480	Glutathione metabolism	2/1199	55/7206	0.00563380371801
ko05321	Inflammatory bowel disease (IBD)	2/1199	56/7206	0.00582624760917
ko04270	Vascular smooth muscle contraction	39/1199	154/7206	0.0058898560237
ko04915	Estrogen signaling pathway	34/1199	131/7206	0.00613456048724
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1199	182/7206	0.00623184177938
ko00240	Pyrimidine metabolism	8/1199	110/7206	0.00626232035335
ko05110	Vibrio cholerae infection	19/1199	63/7206	0.0063203498473
ko04966	Collecting duct acid secretion	10/1199	26/7206	0.00639671806724
ko00310	Lysine degradation	4/1199	73/7206	0.00674575233256
ko03022	Basal transcription factors	1/1199	44/7206	0.00681195647888
ko04115	p53 signaling pathway	4/1199	74/7206	0.00686212310177
ko05161	Hepatitis B	16/1199	173/7206	0.00693812817451
ko04371	Apelin signaling pathway	43/1199	177/7206	0.00771429278726
ko04918	Thyroid hormone synthesis	24/1199	86/7206	0.00808400160794
ko04923	Regulation of lipolysis in adipocytes	22/1199	77/7206	0.00816770331671
ko00590	Arachidonic acid metabolism	2/1199	52/7206	0.00819661152878
ko04622	RIG-I-like receptor signaling pathway	3/1199	62/7206	0.00921356080166
ko04350	TGF-beta signaling pathway	8/1199	103/7206	0.011238069546
ko04064	NF-kappa B signaling pathway	7/1199	96/7206	0.0121908782093
ko05166	HTLV-I infection	33/1199	292/7206	0.0126202453679
ko04657	IL-17 signaling pathway	6/1199	87/7206	0.0128781834798
ko04912	GnRH signaling pathway	31/1199	122/7206	0.0135063217526
ko00562	Inositol phosphate metabolism	24/1199	89/7206	0.0139174738492
ko05215	Prostate cancer	9/1199	111/7206	0.0139668970648
ko03410	Base excision repair	1/1199	38/7206	0.0147556031034
ko03018	RNA degradation	6/1199	84/7206	0.0174043620012
ko04630	Jak-STAT signaling pathway	12/1199	132/7206	0.0177567172303
ko04960	Aldosterone-regulated sodium reabsorption	13/1199	41/7206	0.0179515383825
ko04722	Neurotrophin signaling pathway	38/1199	160/7206	0.0179969449479
ko05140	Leishmaniasis	5/1199	75/7206	0.0182837166431
ko04217	Necroptosis	18/1199	178/7206	0.0185430438403
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1199	14/7206	0.0188233051104
ko04964	Proximal tubule bicarbonate reclamation	10/1199	29/7206	0.0200756085773
ko04973	Carbohydrate digestion and absorption	13/1199	42/7206	0.0201585985562
ko04626	Plant-pathogen interaction	7/1199	18/7206	0.020320677388
ko05202	Transcriptional misregulation in cancer	20/1199	188/7206	0.0225179454782
ko04916	Melanogenesis	34/1199	142/7206	0.0225250991382
ko05131	Shigellosis	6/1199	82/7206	0.0239141209023
ko00280	Valine, leucine and isoleucine degradation	3/1199	54/7206	0.0263188534217
ko04658	Th1 and Th2 cell differentiation	8/1199	96/7206	0.0265970018236
ko05133	Pertussis	7/1199	87/7206	0.0291051934171
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1199	100/7206	0.0298749756291
ko00860	Porphyrin and chlorophyll metabolism	1/1199	34/7206	0.0340019542556
ko04113	Meiosis - yeast	5/1199	70/7206	0.0343929483798
ko00330	Arginine and proline metabolism	4/1199	61/7206	0.0363825216092
ko04120	Ubiquitin mediated proteolysis	14/1199	138/7206	0.0375877468952
ko04930	Type II diabetes mellitus	15/1199	54/7206	0.0409832028359
ko04620	Toll-like receptor signaling pathway	9/1199	100/7206	0.0415199095356
ko04071	Sphingolipid signaling pathway	37/1199	162/7206	0.0417929044241
ko04210	Apoptosis	20/1199	180/7206	0.042685506577
ko04142	Lysosome	16/1199	151/7206	0.0462776358372
ko05340	Primary immunodeficiency	1/1199	30/7206	0.0487671910784
ko05418	Fluid shear stress and atherosclerosis	19/1199	173/7206	0.0488391656185