ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	217/1366	423/7206	2.77579744185e-54
ko04724	Glutamatergic synapse	95/1366	152/7206	7.31340793051e-33
ko05033	Nicotine addiction	50/1366	56/7206	3.63826741576e-30
ko04713	Circadian entrainment	84/1366	136/7206	1.28941331836e-28
ko05032	Morphine addiction	72/1366	110/7206	5.78131380371e-27
ko04727	GABAergic synapse	70/1366	110/7206	3.8413457246e-25
ko04020	Calcium signaling pathway	115/1366	265/7206	1.05575212403e-20
ko04721	Synaptic vesicle cycle	53/1366	80/7206	1.64492289773e-20
ko04725	Cholinergic synapse	81/1366	160/7206	6.93611582213e-20
ko04728	Dopaminergic synapse	89/1366	185/7206	7.86832034844e-20
ko04024	cAMP signaling pathway	113/1366	279/7206	1.5353142673e-17
ko04723	Retrograde endocannabinoid signaling	82/1366	175/7206	1.77536062112e-17
ko04911	Insulin secretion	62/1366	117/7206	9.59164836471e-17
ko04726	Serotonergic synapse	67/1366	137/7206	1.15652504962e-15
ko04744	Phototransduction	29/1366	36/7206	1.85203900357e-15
ko04921	Oxytocin signaling pathway	88/1366	209/7206	5.03575452371e-15
ko04742	Taste transduction	39/1366	61/7206	1.20957218243e-14
ko04970	Salivary secretion	49/1366	95/7206	6.54506292625e-13
ko04720	Long-term potentiation	50/1366	99/7206	1.08456990985e-12
ko05031	Amphetamine addiction	47/1366	91/7206	1.82754178553e-12
ko04740	Olfactory transduction	41/1366	80/7206	6.65864247663e-11
ko03010	Ribosome	1/1366	129/7206	7.22503916925e-11
ko04261	Adrenergic signaling in cardiomyocytes	78/1366	205/7206	8.82464327176e-11
ko03040	Spliceosome	3/1366	145/7206	5.59478733081e-10
ko04022	cGMP-PKG signaling pathway	79/1366	216/7206	8.87465309688e-10
ko04925	Aldosterone synthesis and secretion	46/1366	105/7206	3.82282418713e-09
ko05203	Viral carcinogenesis	20/1366	277/7206	2.98763909008e-08
ko03013	RNA transport	7/1366	166/7206	3.07219893559e-08
ko05168	Herpes simplex infection	9/1366	182/7206	4.46120454717e-08
ko04971	Gastric acid secretion	42/1366	98/7206	6.12348480698e-08
ko04540	Gap junction	50/1366	128/7206	8.2963557079e-08
ko04060	Cytokine-cytokine receptor interaction	11/1366	191/7206	1.69653499416e-07
ko04360	Axon guidance	77/1366	233/7206	2.31586035203e-07
ko05030	Cocaine addiction	33/1366	73/7206	2.39970517325e-07
ko05322	Systemic lupus erythematosus	7/1366	151/7206	2.98828831809e-07
ko04730	Long-term depression	33/1366	78/7206	1.61102411847e-06
ko04924	Renin secretion	35/1366	86/7206	2.49456361392e-06
ko04070	Phosphatidylinositol signaling system	42/1366	112/7206	4.04529551873e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	31/1366	74/7206	7.07830010243e-06
ko04972	Pancreatic secretion	41/1366	111/7206	7.27531474982e-06
ko04976	Bile secretion	32/1366	80/7206	1.01776310248e-05
ko04966	Collecting duct acid secretion	15/1366	26/7206	1.27498457399e-05
ko04745	Phototransduction - fly	19/1366	38/7206	1.48298589333e-05
ko04010	MAPK signaling pathway	92/1366	321/7206	1.53882030592e-05
ko04610	Complement and coagulation cascades	2/1366	79/7206	1.74962684083e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1366	79/7206	1.74962684083e-05
ko04621	NOD-like receptor signaling pathway	11/1366	157/7206	3.05216874486e-05
ko04964	Proximal tubule bicarbonate reclamation	15/1366	29/7206	7.20277395899e-05
ko04371	Apelin signaling pathway	55/1366	177/7206	8.83598708197e-05
ko04072	Phospholipase D signaling pathway	60/1366	197/7206	9.2697213119e-05
ko04750	Inflammatory mediator regulation of TRP channels	41/1366	122/7206	9.94916453323e-05
ko04514	Cell adhesion molecules (CAMs)	43/1366	130/7206	0.000103257363169
ko04141	Protein processing in endoplasmic reticulum	16/1366	184/7206	0.000125302552889
ko05169	Epstein-Barr virus infection	19/1366	206/7206	0.000135721012217
ko04110	Cell cycle	11/1366	145/7206	0.000155544709469
ko04120	Ubiquitin mediated proteolysis	10/1366	138/7206	0.000159943543796
ko04915	Estrogen signaling pathway	43/1366	131/7206	0.000166393061052
ko04064	NF-kappa B signaling pathway	5/1366	96/7206	0.000184533607939
ko05164	Influenza A	14/1366	167/7206	0.000190825194575
ko04260	Cardiac muscle contraction	34/1366	98/7206	0.000217596792715
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/1366	79/7206	0.000220853058947
ko05140	Leishmaniasis	3/1366	75/7206	0.000279556121802
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1366	59/7206	0.00031796823621
ko04014	Ras signaling pathway	77/1366	279/7206	0.000319683375576
ko04923	Regulation of lipolysis in adipocytes	28/1366	77/7206	0.00033418523803
ko05414	Dilated cardiomyopathy	37/1366	112/7206	0.000355433535012
ko05205	Proteoglycans in cancer	30/1366	271/7206	0.000477791624354
ko05110	Vibrio cholerae infection	24/1366	63/7206	0.000498082967497
ko04146	Peroxisome	5/1366	89/7206	0.000542488946294
ko04626	Plant-pathogen interaction	10/1366	18/7206	0.000573343301199
ko04922	Glucagon signaling pathway	40/1366	128/7206	0.000846889511068
ko03420	Nucleotide excision repair	1/1366	46/7206	0.00109516943347
ko00310	Lysine degradation	4/1366	73/7206	0.0014398668813
ko00520	Amino sugar and nucleotide sugar metabolism	2/1366	55/7206	0.00153829756895
ko00480	Glutathione metabolism	2/1366	55/7206	0.00153829756895
ko05321	Inflammatory bowel disease (IBD)	2/1366	56/7206	0.00160531412994
ko03022	Basal transcription factors	1/1366	44/7206	0.00166629245519
ko05144	Malaria	1/1366	45/7206	0.00170895723278
ko00071	Fatty acid degradation	1/1366	45/7206	0.00170895723278
ko05162	Measles	10/1366	120/7206	0.00203354017125
ko00240	Pyrimidine metabolism	9/1366	110/7206	0.0020871205619
ko04657	IL-17 signaling pathway	6/1366	87/7206	0.00223638091822
ko04622	RIG-I-like receptor signaling pathway	3/1366	62/7206	0.00282467478193
ko03018	RNA degradation	6/1366	84/7206	0.00313248135848
ko05131	Shigellosis	6/1366	82/7206	0.00435453878997
ko04115	p53 signaling pathway	5/1366	74/7206	0.00436829498258
ko04710	Circadian rhythm	16/1366	43/7206	0.005101657564
ko04658	Th1 and Th2 cell differentiation	8/1366	96/7206	0.00555724661887
ko05161	Hepatitis B	19/1366	173/7206	0.00574813879827
ko00630	Glyoxylate and dicarboxylate metabolism	1/1366	38/7206	0.00589569283828
ko05231	Choline metabolism in cancer	38/1366	134/7206	0.00731390813302
ko05133	Pertussis	7/1366	87/7206	0.00822001052423
ko04612	Antigen processing and presentation	6/1366	77/7206	0.00838692991782
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1366	14/7206	0.00853773346805
ko04330	Notch signaling pathway	4/1366	62/7206	0.00858694016267
ko04912	GnRH signaling pathway	35/1366	122/7206	0.0098209431765
ko05145	Toxoplasmosis	13/1366	126/7206	0.0112375484614
ko00590	Arachidonic acid metabolism	3/1366	52/7206	0.0118934498385
ko04213	Longevity regulating pathway - multiple species	26/1366	86/7206	0.0119016184888
ko04918	Thyroid hormone synthesis	26/1366	86/7206	0.0119016184888
ko04270	Vascular smooth muscle contraction	42/1366	154/7206	0.0121446075943
ko04916	Melanogenesis	39/1366	142/7206	0.0124746982158
ko05132	Salmonella infection	9/1366	98/7206	0.0129070237363
ko04930	Type II diabetes mellitus	18/1366	54/7206	0.0131371672954
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1366	100/7206	0.0140586502342
ko00562	Inositol phosphate metabolism	26/1366	89/7206	0.0196879546995
ko04620	Toll-like receptor signaling pathway	10/1366	100/7206	0.0201757640255
ko04214	Apoptosis - fly	6/1366	72/7206	0.022080799312
ko00290	Valine, leucine and isoleucine biosynthesis	3/1366	4/7206	0.0233390690045
ko04640	Hematopoietic cell lineage	5/1366	64/7206	0.0234318128497
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1366	40/7206	0.0237854996554
ko04142	Lysosome	18/1366	151/7206	0.0269898079339
ko05166	HTLV-I infection	41/1366	292/7206	0.0271337075019
ko04973	Carbohydrate digestion and absorption	14/1366	42/7206	0.0273704031593
ko04015	Rap1 signaling pathway	67/1366	278/7206	0.0287914262434
ko05214	Glioma	23/1366	79/7206	0.02912180323
ko05320	Autoimmune thyroid disease	1/1366	29/7206	0.0305786868073
ko04350	TGF-beta signaling pathway	11/1366	103/7206	0.0307869667763
ko04210	Apoptosis	23/1366	180/7206	0.0336779873529
ko00280	Valine, leucine and isoleucine degradation	4/1366	54/7206	0.0343718427342
ko03410	Base excision repair	2/1366	38/7206	0.0349855960288
ko04978	Mineral absorption	13/1366	40/7206	0.0404847366732
ko04217	Necroptosis	23/1366	178/7206	0.0414245076117
ko04630	Jak-STAT signaling pathway	16/1366	132/7206	0.0434567024824
ko04668	TNF signaling pathway	14/1366	120/7206	0.0449609685762
ko04960	Aldosterone-regulated sodium reabsorption	13/1366	41/7206	0.044984145497
ko00040	Pentose and glucuronate interconversions	1/1366	26/7206	0.0458200635478
ko04974	Protein digestion and absorption	26/1366	96/7206	0.0485627650248
ko00860	Porphyrin and chlorophyll metabolism	2/1366	34/7206	0.049178205565