ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	217/1327	423/7206	1.1744452657e-56
ko04724	Glutamatergic synapse	94/1327	152/7206	4.77136492077e-33
ko05033	Nicotine addiction	50/1327	56/7206	8.65165973509e-31
ko04713	Circadian entrainment	82/1327	136/7206	7.94258609425e-28
ko05032	Morphine addiction	72/1327	110/7206	8.70264023696e-28
ko04727	GABAergic synapse	69/1327	110/7206	4.96217547017e-25
ko04721	Synaptic vesicle cycle	55/1327	80/7206	4.52409895007e-23
ko04020	Calcium signaling pathway	113/1327	265/7206	1.33441001867e-20
ko04728	Dopaminergic synapse	88/1327	185/7206	4.44090230788e-20
ko04725	Cholinergic synapse	78/1327	160/7206	1.02451103151e-18
ko04024	cAMP signaling pathway	113/1327	279/7206	2.06150233512e-18
ko04723	Retrograde endocannabinoid signaling	80/1327	175/7206	4.59763701454e-17
ko04742	Taste transduction	40/1327	61/7206	5.30825482483e-16
ko04911	Insulin secretion	60/1327	117/7206	5.56867313413e-16
ko04744	Phototransduction	29/1327	36/7206	8.28661457801e-16
ko04921	Oxytocin signaling pathway	88/1327	209/7206	8.62919874936e-16
ko04726	Serotonergic synapse	64/1327	137/7206	1.92750523052e-14
ko04970	Salivary secretion	49/1327	95/7206	2.07829412176e-13
ko04720	Long-term potentiation	50/1327	99/7206	3.40809639819e-13
ko04740	Olfactory transduction	43/1327	80/7206	9.94858039464e-13
ko04261	Adrenergic signaling in cardiomyocytes	80/1327	205/7206	2.78975858737e-12
ko05031	Amphetamine addiction	46/1327	91/7206	2.92537311662e-12
ko03040	Spliceosome	1/1327	145/7206	5.63264421555e-12
ko05203	Viral carcinogenesis	17/1327	277/7206	2.85220480284e-09
ko05168	Herpes simplex infection	7/1327	182/7206	4.81023424418e-09
ko04925	Aldosterone synthesis and secretion	45/1327	105/7206	5.2468830251e-09
ko04971	Gastric acid secretion	43/1327	98/7206	6.31028391075e-09
ko04022	cGMP-PKG signaling pathway	75/1327	216/7206	6.47290773965e-09
ko04360	Axon guidance	78/1327	233/7206	2.28844453071e-08
ko03013	RNA transport	7/1327	166/7206	7.19470868217e-08
ko04540	Gap junction	49/1327	128/7206	1.00147116447e-07
ko04924	Renin secretion	36/1327	86/7206	3.6182417893e-07
ko04060	Cytokine-cytokine receptor interaction	11/1327	191/7206	3.74981125665e-07
ko05030	Cocaine addiction	32/1327	73/7206	4.35278794346e-07
ko04120	Ubiquitin mediated proteolysis	6/1327	138/7206	1.19918806895e-06
ko04966	Collecting duct acid secretion	16/1327	26/7206	1.32060814618e-06
ko05164	Influenza A	9/1327	167/7206	1.33920095629e-06
ko05322	Systemic lupus erythematosus	8/1327	151/7206	3.45247754973e-06
ko04141	Protein processing in endoplasmic reticulum	12/1327	184/7206	4.43421451692e-06
ko04260	Cardiac muscle contraction	37/1327	98/7206	5.16636375025e-06
ko05169	Epstein-Barr virus infection	15/1327	206/7206	6.20480027529e-06
ko04745	Phototransduction - fly	19/1327	38/7206	9.58217399195e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1327	74/7206	1.17694353478e-05
ko04621	NOD-like receptor signaling pathway	10/1327	157/7206	1.60820107388e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	25/1327	59/7206	2.21249518196e-05
ko05110	Vibrio cholerae infection	26/1327	63/7206	2.21298318223e-05
ko05162	Measles	6/1327	120/7206	2.37601149635e-05
ko04730	Long-term depression	30/1327	78/7206	2.62466947577e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1327	79/7206	2.79896064076e-05
ko04514	Cell adhesion molecules (CAMs)	44/1327	130/7206	2.84335138737e-05
ko04972	Pancreatic secretion	39/1327	111/7206	3.18508332634e-05
ko04750	Inflammatory mediator regulation of TRP channels	41/1327	122/7206	4.87773641105e-05
ko04064	NF-kappa B signaling pathway	4/1327	96/7206	5.18740969519e-05
ko04976	Bile secretion	30/1327	80/7206	5.65876894207e-05
ko05140	Leishmaniasis	2/1327	75/7206	6.42092613703e-05
ko04626	Plant-pathogen interaction	11/1327	18/7206	7.07187100334e-05
ko04010	MAPK signaling pathway	87/1327	321/7206	8.72476078999e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/1327	79/7206	0.00010587356671
ko05205	Proteoglycans in cancer	27/1327	271/7206	0.000117149696478
ko04110	Cell cycle	10/1327	145/7206	0.000123527931036
ko04371	Apelin signaling pathway	53/1327	177/7206	0.000165681665537
ko05414	Dilated cardiomyopathy	37/1327	112/7206	0.000184129497792
ko04070	Phosphatidylinositol signaling system	37/1327	112/7206	0.000184129497792
ko00520	Amino sugar and nucleotide sugar metabolism	1/1327	55/7206	0.00032463789363
ko04915	Estrogen signaling pathway	41/1327	131/7206	0.000355258025747
ko04964	Proximal tubule bicarbonate reclamation	13/1327	29/7206	0.000949591969692
ko05161	Hepatitis B	16/1327	173/7206	0.000981308756691
ko04612	Antigen processing and presentation	4/1327	77/7206	0.00103971059991
ko04610	Complement and coagulation cascades	4/1327	79/7206	0.00107593865878
ko04014	Ras signaling pathway	73/1327	279/7206	0.00117458951225
ko00240	Pyrimidine metabolism	8/1327	110/7206	0.00118061015535
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1327	14/7206	0.00135282741776
ko01524	Platinum drug resistance	4/1327	76/7206	0.00150685016264
ko05321	Inflammatory bowel disease (IBD)	2/1327	56/7206	0.00158569328701
ko03018	RNA degradation	5/1327	84/7206	0.00160436304026
ko00071	Fatty acid degradation	1/1327	45/7206	0.00172696835937
ko03420	Nucleotide excision repair	1/1327	46/7206	0.0017449419612
ko05131	Shigellosis	5/1327	82/7206	0.00228842346674
ko04146	Peroxisome	6/1327	89/7206	0.00230807300333
ko00480	Glutathione metabolism	2/1327	55/7206	0.002416734299
ko03022	Basal transcription factors	1/1327	44/7206	0.00267803680688
ko04072	Phospholipase D signaling pathway	53/1327	197/7206	0.00276393204806
ko04622	RIG-I-like receptor signaling pathway	3/1327	62/7206	0.00279146781517
ko04270	Vascular smooth muscle contraction	43/1327	154/7206	0.00315862746201
ko04214	Apoptosis - fly	4/1327	72/7206	0.00316590516336
ko04657	IL-17 signaling pathway	6/1327	87/7206	0.00321881355961
ko05145	Toxoplasmosis	11/1327	126/7206	0.00348237685595
ko00590	Arachidonic acid metabolism	2/1327	52/7206	0.00349238001486
ko04916	Melanogenesis	40/1327	142/7206	0.00419379095359
ko04912	GnRH signaling pathway	35/1327	122/7206	0.00460092942779
ko04620	Toll-like receptor signaling pathway	8/1327	100/7206	0.0058441128958
ko00630	Glyoxylate and dicarboxylate metabolism	1/1327	38/7206	0.00604571201517
ko04668	TNF signaling pathway	11/1327	120/7206	0.00613828516928
ko04115	p53 signaling pathway	5/1327	74/7206	0.00629470097589
ko04923	Regulation of lipolysis in adipocytes	24/1327	77/7206	0.00703642063532
ko04658	Th1 and Th2 cell differentiation	8/1327	96/7206	0.00772319804073
ko05166	HTLV-I infection	37/1327	292/7206	0.00866928399427
ko04630	Jak-STAT signaling pathway	13/1327	132/7206	0.00880624153441
ko04640	Hematopoietic cell lineage	4/1327	64/7206	0.0088200817252
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1327	100/7206	0.00893258474016
ko00310	Lysine degradation	5/1327	73/7206	0.00899806118145
ko05144	Malaria	2/1327	45/7206	0.0111270234292
ko04922	Glucagon signaling pathway	35/1327	128/7206	0.0111896093466
ko00330	Arginine and proline metabolism	4/1327	61/7206	0.0123988056194
ko04932	Non-alcoholic fatty liver disease (NAFLD)	21/1327	182/7206	0.0150707515848
ko04918	Thyroid hormone synthesis	25/1327	86/7206	0.01634374059
ko04974	Protein digestion and absorption	27/1327	96/7206	0.016927674812
ko05418	Fluid shear stress and atherosclerosis	20/1327	173/7206	0.0169747504129
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	10/1327	26/7206	0.0181309920598
ko05215	Prostate cancer	11/1327	111/7206	0.0185161125062
ko05222	Small cell lung cancer	8/1327	89/7206	0.0188046125071
ko00290	Valine, leucine and isoleucine biosynthesis	3/1327	4/7206	0.0214964405926
ko04015	Rap1 signaling pathway	66/1327	278/7206	0.0220573357015
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1327	40/7206	0.0237012137589
ko04140	Autophagy - animal	19/1327	164/7206	0.02435941585
ko05133	Pertussis	8/1327	87/7206	0.025153287527
ko05320	Autoimmune thyroid disease	1/1327	29/7206	0.0310827032541
ko04210	Apoptosis	22/1327	180/7206	0.0316525096836
ko04330	Notch signaling pathway	5/1327	62/7206	0.0321217749668
ko00600	Sphingolipid metabolism	5/1327	63/7206	0.0323961332233
ko00280	Valine, leucine and isoleucine degradation	4/1327	54/7206	0.0339717445433
ko03410	Base excision repair	2/1327	38/7206	0.0345053356103
ko05132	Salmonella infection	10/1327	98/7206	0.0351337812317
ko04978	Mineral absorption	13/1327	40/7206	0.0373988744044
ko05206	MicroRNAs in cancer	22/1327	177/7206	0.0388346285734
ko04217	Necroptosis	22/1327	178/7206	0.0391168221989
ko05034	Alcoholism	56/1327	238/7206	0.0413314904355
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1327	15/7206	0.0426178774564
ko04142	Lysosome	18/1327	151/7206	0.0429959110412
ko05212	Pancreatic cancer	8/1327	83/7206	0.044647701198
ko04114	Oocyte meiosis	35/1327	139/7206	0.0459834965084
ko00500	Starch and sucrose metabolism	2/1327	35/7206	0.0499129553209