ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	193/1028	423/7206	8.93836301353e-59
ko04724	Glutamatergic synapse	87/1028	152/7206	8.54752231883e-36
ko05033	Nicotine addiction	48/1028	56/7206	4.38941992917e-33
ko04727	GABAergic synapse	63/1028	110/7206	3.6963460463e-26
ko05032	Morphine addiction	63/1028	110/7206	3.6963460463e-26
ko04713	Circadian entrainment	71/1028	136/7206	5.35484305005e-26
ko04728	Dopaminergic synapse	81/1028	185/7206	5.37577658068e-23
ko04725	Cholinergic synapse	71/1028	160/7206	1.11222656277e-20
ko04723	Retrograde endocannabinoid signaling	74/1028	175/7206	5.30818187252e-20
ko04024	cAMP signaling pathway	99/1028	279/7206	9.88014012741e-20
ko04911	Insulin secretion	55/1028	117/7206	1.15267918233e-17
ko04721	Synaptic vesicle cycle	43/1028	80/7206	8.24455511969e-17
ko04020	Calcium signaling pathway	90/1028	265/7206	1.69443312035e-16
ko04726	Serotonergic synapse	56/1028	137/7206	1.24532849911e-14
ko04921	Oxytocin signaling pathway	73/1028	209/7206	2.84991375352e-14
ko04744	Phototransduction	24/1028	36/7206	8.89964797244e-13
ko05031	Amphetamine addiction	41/1028	91/7206	1.02150128392e-12
ko04742	Taste transduction	32/1028	61/7206	1.87952691742e-12
ko04720	Long-term potentiation	42/1028	99/7206	6.31476106609e-12
ko04261	Adrenergic signaling in cardiomyocytes	67/1028	205/7206	9.57330008775e-12
ko04740	Olfactory transduction	36/1028	80/7206	2.62970777781e-11
ko05030	Cocaine addiction	32/1028	73/7206	7.73329674687e-10
ko04970	Salivary secretion	37/1028	95/7206	2.12062593004e-09
ko03040	Spliceosome	1/1028	145/7206	9.51959336267e-09
ko04925	Aldosterone synthesis and secretion	37/1028	105/7206	4.96081619991e-08
ko04971	Gastric acid secretion	35/1028	98/7206	7.76584327404e-08
ko05203	Viral carcinogenesis	12/1028	277/7206	9.16479761358e-08
ko04010	MAPK signaling pathway	80/1028	321/7206	2.03050038505e-07
ko04360	Axon guidance	63/1028	233/7206	2.75606503516e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1028	74/7206	3.95167969003e-07
ko05322	Systemic lupus erythematosus	4/1028	151/7206	2.67515432458e-06
ko04022	cGMP-PKG signaling pathway	56/1028	216/7206	4.20963971744e-06
ko05168	Herpes simplex infection	7/1028	182/7206	4.83520881514e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1028	79/7206	6.22766754978e-06
ko04972	Pancreatic secretion	34/1028	111/7206	7.32764836201e-06
ko04060	Cytokine-cytokine receptor interaction	8/1028	191/7206	7.76739079384e-06
ko05164	Influenza A	6/1028	167/7206	8.7065641041e-06
ko04141	Protein processing in endoplasmic reticulum	8/1028	184/7206	1.53423031045e-05
ko04260	Cardiac muscle contraction	30/1028	98/7206	2.77614593129e-05
ko04540	Gap junction	36/1028	128/7206	3.40925936701e-05
ko03013	RNA transport	7/1028	166/7206	4.02467197591e-05
ko04730	Long-term depression	25/1028	78/7206	5.29745871191e-05
ko04514	Cell adhesion molecules (CAMs)	36/1028	130/7206	6.18504224196e-05
ko04120	Ubiquitin mediated proteolysis	5/1028	138/7206	6.32622749201e-05
ko05414	Dilated cardiomyopathy	32/1028	112/7206	9.48197153136e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1028	59/7206	0.000111778198293
ko04745	Phototransduction - fly	15/1028	38/7206	0.00011482595495
ko04072	Phospholipase D signaling pathway	48/1028	197/7206	0.000117815243365
ko04750	Inflammatory mediator regulation of TRP channels	33/1028	122/7206	0.000196906371938
ko04612	Antigen processing and presentation	1/1028	77/7206	0.000202661103512
ko04976	Bile secretion	24/1028	80/7206	0.000272517720661
ko04621	NOD-like receptor signaling pathway	8/1028	157/7206	0.000308911402713
ko04110	Cell cycle	7/1028	145/7206	0.000424007114039
ko04014	Ras signaling pathway	61/1028	279/7206	0.000446248646484
ko04924	Renin secretion	25/1028	86/7206	0.000468007490591
ko05169	Epstein-Barr virus infection	13/1028	206/7206	0.000521298494257
ko05162	Measles	5/1028	120/7206	0.000521609284333
ko04350	TGF-beta signaling pathway	4/1028	103/7206	0.000944331831477
ko03008	Ribosome biogenesis in eukaryotes	2/1028	79/7206	0.000957351191626
ko04070	Phosphatidylinositol signaling system	29/1028	112/7206	0.000962274955058
ko04146	Peroxisome	3/1028	89/7206	0.00117376916365
ko04932	Non-alcoholic fatty liver disease (NAFLD)	12/1028	182/7206	0.00170603910413
ko04915	Estrogen signaling pathway	32/1028	131/7206	0.00218673159616
ko00480	Glutathione metabolism	1/1028	55/7206	0.00327483298784
ko05161	Hepatitis B	12/1028	173/7206	0.00395528557585
ko05205	Proteoglycans in cancer	23/1028	271/7206	0.00445376982247
ko04964	Proximal tubule bicarbonate reclamation	10/1028	29/7206	0.00508419661477
ko04610	Complement and coagulation cascades	3/1028	79/7206	0.00515275547014
ko04630	Jak-STAT signaling pathway	8/1028	132/7206	0.00524595405136
ko04015	Rap1 signaling pathway	56/1028	278/7206	0.00647469611899
ko05140	Leishmaniasis	3/1028	75/7206	0.0071362350249
ko04966	Collecting duct acid secretion	9/1028	26/7206	0.0075365647218
ko04064	NF-kappa B signaling pathway	5/1028	96/7206	0.00761468869108
ko04912	GnRH signaling pathway	28/1028	122/7206	0.00863364871545
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1028	100/7206	0.00880514452835
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1028	14/7206	0.00895551611371
ko04330	Notch signaling pathway	2/1028	62/7206	0.00932432508587
ko04214	Apoptosis - fly	3/1028	72/7206	0.0101294472205
ko05166	HTLV-I infection	27/1028	292/7206	0.0103151082436
ko00310	Lysine degradation	3/1028	73/7206	0.0103797403941
ko00260	Glycine, serine and threonine metabolism	1/1028	48/7206	0.0111097747829
ko04142	Lysosome	11/1028	151/7206	0.0128611754994
ko00240	Pyrimidine metabolism	7/1028	110/7206	0.0131229964587
ko04923	Regulation of lipolysis in adipocytes	19/1028	77/7206	0.0132411526402
ko04973	Carbohydrate digestion and absorption	12/1028	42/7206	0.0134994111507
ko05418	Fluid shear stress and atherosclerosis	14/1028	173/7206	0.015456086311
ko05144	Malaria	1/1028	45/7206	0.0164207183065
ko00071	Fatty acid degradation	1/1028	45/7206	0.0164207183065
ko00620	Pyruvate metabolism	1/1028	46/7206	0.0171655091485
ko03420	Nucleotide excision repair	1/1028	46/7206	0.0171655091485
ko05110	Vibrio cholerae infection	16/1028	63/7206	0.0173549981857
ko05321	Inflammatory bowel disease (IBD)	2/1028	56/7206	0.0193399081178
ko04657	IL-17 signaling pathway	5/1028	87/7206	0.0197445689599
ko05133	Pertussis	5/1028	87/7206	0.0197445689599
ko05145	Toxoplasmosis	9/1028	126/7206	0.0199448403003
ko01524	Platinum drug resistance	4/1028	76/7206	0.0202130942179
ko00140	Steroid hormone biosynthesis	1/1028	41/7206	0.0238118233449
ko04658	Th1 and Th2 cell differentiation	6/1028	96/7206	0.0260320811657
ko03018	RNA degradation	5/1028	84/7206	0.0269089175135
ko04918	Thyroid hormone synthesis	20/1028	86/7206	0.0280828998236
ko04622	RIG-I-like receptor signaling pathway	3/1028	62/7206	0.0282216535937
ko05215	Prostate cancer	8/1028	111/7206	0.0285486345406
ko04371	Apelin signaling pathway	36/1028	177/7206	0.0287045189233
ko04930	Type II diabetes mellitus	14/1028	54/7206	0.0287317300234
ko04640	Hematopoietic cell lineage	3/1028	64/7206	0.02899064248
ko04071	Sphingolipid signaling pathway	33/1028	162/7206	0.0303365065577
ko04550	Signaling pathways regulating pluripotency of stem cells	14/1028	165/7206	0.0318020757576
ko04626	Plant-pathogen interaction	6/1028	18/7206	0.0334907627686
ko00630	Glyoxylate and dicarboxylate metabolism	1/1028	38/7206	0.0351909518692
ko03410	Base excision repair	1/1028	38/7206	0.0351909518692
ko05016	Huntington's disease	20/1028	215/7206	0.0369920122029
ko05131	Shigellosis	5/1028	82/7206	0.0370879548241
ko04510	Focal adhesion	23/1028	240/7206	0.0382896969475
ko05219	Bladder cancer	2/1028	48/7206	0.0390036550087
ko04217	Necroptosis	16/1028	178/7206	0.0393076387867
ko04210	Apoptosis	16/1028	180/7206	0.0395357568364
ko01200	Carbon metabolism	10/1028	128/7206	0.0400540843065
ko00330	Arginine and proline metabolism	3/1028	61/7206	0.0405219951272
ko04620	Toll-like receptor signaling pathway	7/1028	100/7206	0.0421457385485
ko04670	Leukocyte transendothelial migration	13/1028	151/7206	0.0451490586133
ko05222	Small cell lung cancer	6/1028	89/7206	0.0457351982163
ko05034	Alcoholism	45/1028	238/7206	0.0470779300248
ko04218	Cellular senescence	16/1028	177/7206	0.0492684553876