ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	197/1170	423/7206	4.92329018558e-52
ko04724	Glutamatergic synapse	95/1170	152/7206	1.07896954162e-38
ko05033	Nicotine addiction	50/1170	56/7206	1.6392184998e-33
ko05032	Morphine addiction	71/1170	110/7206	2.08501853999e-30
ko04727	GABAergic synapse	69/1170	110/7206	1.89332063797e-28
ko04713	Circadian entrainment	78/1170	136/7206	2.83944254819e-28
ko04728	Dopaminergic synapse	91/1170	185/7206	4.13067910333e-26
ko04725	Cholinergic synapse	79/1170	160/7206	6.47856248148e-23
ko04723	Retrograde endocannabinoid signaling	81/1170	175/7206	3.52981097573e-21
ko04024	cAMP signaling pathway	106/1170	279/7206	4.79674987041e-19
ko04721	Synaptic vesicle cycle	48/1170	80/7206	5.87502174617e-19
ko04911	Insulin secretion	59/1170	117/7206	5.92915318146e-18
ko04020	Calcium signaling pathway	97/1170	265/7206	2.35768589946e-16
ko04744	Phototransduction	28/1170	36/7206	4.75093355212e-16
ko04726	Serotonergic synapse	62/1170	137/7206	6.99457449839e-16
ko04921	Oxytocin signaling pathway	81/1170	209/7206	1.63910090008e-15
ko05031	Amphetamine addiction	46/1170	91/7206	2.54066989116e-14
ko04261	Adrenergic signaling in cardiomyocytes	77/1170	205/7206	6.33241734015e-14
ko04742	Taste transduction	35/1170	61/7206	2.3954990662e-13
ko04720	Long-term potentiation	46/1170	99/7206	1.28882512334e-12
ko04970	Salivary secretion	42/1170	95/7206	9.09261359762e-11
ko05030	Cocaine addiction	35/1170	73/7206	2.1948103436e-10
ko03040	Spliceosome	1/1170	145/7206	3.21788272972e-10
ko04925	Aldosterone synthesis and secretion	43/1170	105/7206	1.05288993342e-09
ko04971	Gastric acid secretion	41/1170	98/7206	1.19572058541e-09
ko04740	Olfactory transduction	34/1170	80/7206	1.94854254365e-08
ko05203	Viral carcinogenesis	16/1170	277/7206	1.15873823464e-07
ko04360	Axon guidance	69/1170	233/7206	1.83315422869e-07
ko04022	cGMP-PKG signaling pathway	65/1170	216/7206	2.64092869261e-07
ko04010	MAPK signaling pathway	87/1170	321/7206	3.90331430385e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1170	74/7206	4.63877873914e-07
ko05322	Systemic lupus erythematosus	5/1170	151/7206	9.14020476784e-07
ko04060	Cytokine-cytokine receptor interaction	9/1170	191/7206	1.21116693641e-06
ko04070	Phosphatidylinositol signaling system	39/1170	112/7206	1.57866965311e-06
ko04972	Pancreatic secretion	38/1170	111/7206	2.93245261315e-06
ko05168	Herpes simplex infection	9/1170	182/7206	3.42158622855e-06
ko04730	Long-term depression	29/1170	78/7206	6.66999640501e-06
ko04745	Phototransduction - fly	18/1170	38/7206	6.9648216259e-06
ko03013	RNA transport	8/1170	166/7206	9.09340446525e-06
ko04141	Protein processing in endoplasmic reticulum	10/1170	184/7206	1.0252071955e-05
ko04610	Complement and coagulation cascades	1/1170	79/7206	2.0374610661e-05
ko04072	Phospholipase D signaling pathway	55/1170	197/7206	3.08640802036e-05
ko04612	Antigen processing and presentation	1/1170	77/7206	3.12529182415e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1170	79/7206	3.62005136781e-05
ko04915	Estrogen signaling pathway	39/1170	131/7206	9.96136330272e-05
ko04621	NOD-like receptor signaling pathway	9/1170	157/7206	0.000104021239187
ko04540	Gap junction	38/1170	128/7206	0.000137145912406
ko04110	Cell cycle	8/1170	145/7206	0.000140895196653
ko04260	Cardiac muscle contraction	31/1170	98/7206	0.000142913120915
ko05414	Dilated cardiomyopathy	34/1170	112/7206	0.000151222247616
ko04514	Cell adhesion molecules (CAMs)	38/1170	130/7206	0.000164945933459
ko03008	Ribosome biogenesis in eukaryotes	2/1170	79/7206	0.000171913381108
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1170	59/7206	0.000253408862496
ko05164	Influenza A	11/1170	167/7206	0.000265877962282
ko04976	Bile secretion	26/1170	80/7206	0.000323948700001
ko04924	Renin secretion	27/1170	86/7206	0.000543297378281
ko04120	Ubiquitin mediated proteolysis	9/1170	138/7206	0.000974866976071
ko05205	Proteoglycans in cancer	25/1170	271/7206	0.000994675884831
ko05162	Measles	7/1170	120/7206	0.0010085066419
ko04064	NF-kappa B signaling pathway	5/1170	96/7206	0.00186780877474
ko00590	Arachidonic acid metabolism	1/1170	52/7206	0.00198660943566
ko05169	Epstein-Barr virus infection	18/1170	206/7206	0.00206284153445
ko04014	Ras signaling pathway	65/1170	279/7206	0.00207914479605
ko04912	GnRH signaling pathway	33/1170	122/7206	0.00264829081511
ko04750	Inflammatory mediator regulation of TRP channels	33/1170	122/7206	0.00264829081511
ko04371	Apelin signaling pathway	44/1170	177/7206	0.00265063396332
ko04923	Regulation of lipolysis in adipocytes	23/1170	77/7206	0.00267270118028
ko04350	TGF-beta signaling pathway	6/1170	103/7206	0.00269833370351
ko04918	Thyroid hormone synthesis	25/1170	86/7206	0.00279910941837
ko05110	Vibrio cholerae infection	20/1170	63/7206	0.00284522414128
ko05034	Alcoholism	56/1170	238/7206	0.00305024226034
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1170	14/7206	0.00349190794517
ko03420	Nucleotide excision repair	1/1170	46/7206	0.00443813615181
ko04015	Rap1 signaling pathway	63/1170	278/7206	0.00464045230885
ko04062	Chemokine signaling pathway	48/1170	201/7206	0.0046760277557
ko05202	Transcriptional misregulation in cancer	17/1170	188/7206	0.00491698847962
ko04966	Collecting duct acid secretion	10/1170	26/7206	0.00534855788961
ko04916	Melanogenesis	36/1170	142/7206	0.0054129240338
ko04210	Apoptosis	16/1170	180/7206	0.00547765214269
ko05321	Inflammatory bowel disease (IBD)	2/1170	56/7206	0.00571782425096
ko03022	Basal transcription factors	1/1170	44/7206	0.00668315358572
ko05140	Leishmaniasis	4/1170	75/7206	0.00688199986146
ko04115	p53 signaling pathway	4/1170	74/7206	0.00688414673439
ko05144	Malaria	1/1170	45/7206	0.00691293122307
ko00071	Fatty acid degradation	1/1170	45/7206	0.00691293122307
ko03018	RNA degradation	5/1170	84/7206	0.00696605693608
ko00240	Pyrimidine metabolism	8/1170	110/7206	0.00858894091867
ko00480	Glutathione metabolism	2/1170	55/7206	0.00875451187062
ko00562	Inositol phosphate metabolism	24/1170	89/7206	0.00881118156818
ko05161	Hepatitis B	16/1170	173/7206	0.0090396971797
ko04622	RIG-I-like receptor signaling pathway	3/1170	62/7206	0.0093013874789
ko04640	Hematopoietic cell lineage	3/1170	64/7206	0.00950134363367
ko00310	Lysine degradation	4/1170	73/7206	0.00978037209034
ko00140	Steroid hormone biosynthesis	1/1170	41/7206	0.00997804047122
ko04140	Autophagy - animal	15/1170	164/7206	0.0100773643209
ko04711	Circadian rhythm - fly	6/1170	13/7206	0.0110742343056
ko04146	Peroxisome	6/1170	89/7206	0.0130398519631
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1170	100/7206	0.0130590297249
ko05016	Huntington's disease	22/1170	215/7206	0.0143484584475
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1170	40/7206	0.0155441904317
ko04960	Aldosterone-regulated sodium reabsorption	13/1170	41/7206	0.0166025766422
ko04626	Plant-pathogen interaction	7/1170	18/7206	0.0178769184932
ko04973	Carbohydrate digestion and absorption	13/1170	42/7206	0.0181986560531
ko00512	Mucin type O-glycan biosynthesis	10/1170	29/7206	0.0185223155844
ko04964	Proximal tubule bicarbonate reclamation	10/1170	29/7206	0.0185223155844
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1170	182/7206	0.0187072492948
ko05418	Fluid shear stress and atherosclerosis	17/1170	173/7206	0.0211206094502
ko04630	Jak-STAT signaling pathway	12/1170	132/7206	0.0231711224923
ko04217	Necroptosis	18/1170	178/7206	0.0233246105632
ko05231	Choline metabolism in cancer	32/1170	134/7206	0.0237699921563
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1170	15/7206	0.0241753247172
ko04930	Type II diabetes mellitus	15/1170	54/7206	0.0264082853763
ko05166	HTLV-I infection	34/1170	292/7206	0.0286571588889
ko05222	Small cell lung cancer	7/1170	89/7206	0.0294464752591
ko04142	Lysosome	15/1170	151/7206	0.033664094024
ko04113	Meiosis - yeast	5/1170	70/7206	0.0343540249723
ko04975	Fat digestion and absorption	1/1170	35/7206	0.034690779523
ko04214	Apoptosis - fly	5/1170	72/7206	0.0350093664915
ko04270	Vascular smooth muscle contraction	35/1170	154/7206	0.0350744397561
ko04658	Th1 and Th2 cell differentiation	8/1170	96/7206	0.0356375019553
ko04114	Oocyte meiosis	32/1170	139/7206	0.0358228598396
ko00513	Various types of N-glycan biosynthesis	12/1170	42/7206	0.036282538183
ko05145	Toxoplasmosis	12/1170	126/7206	0.0380868895588
ko04722	Neurotrophin signaling pathway	36/1170	160/7206	0.0385984737723
ko04657	IL-17 signaling pathway	7/1170	87/7206	0.0393805459545
ko05214	Glioma	20/1170	79/7206	0.0441862210558
ko03320	PPAR signaling pathway	5/1170	69/7206	0.0471815100838
ko00230	Purine metabolism	42/1170	194/7206	0.0476798320488