ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 64/707 152/7206 3.12776841246e-26 ko05033 Nicotine addiction 37/707 56/7206 1.43876061167e-24 ko04080 Neuroactive ligand-receptor interaction 111/707 423/7206 6.80243305723e-24 ko04727 GABAergic synapse 46/707 110/7206 5.61251063563e-19 ko05032 Morphine addiction 45/707 110/7206 3.88547259748e-18 ko04744 Phototransduction 23/707 36/7206 3.1010411448e-15 ko04713 Circadian entrainment 46/707 136/7206 9.2604349855e-15 ko04723 Retrograde endocannabinoid signaling 53/707 175/7206 1.54660136913e-14 ko04024 cAMP signaling pathway 70/707 279/7206 3.64314301852e-14 ko04728 Dopaminergic synapse 49/707 185/7206 3.81867541376e-11 ko04020 Calcium signaling pathway 61/707 265/7206 1.139474805e-10 ko04721 Synaptic vesicle cycle 28/707 80/7206 7.19251928781e-10 ko04725 Cholinergic synapse 42/707 160/7206 1.34378841836e-09 ko04911 Insulin secretion 34/707 117/7206 3.04642876366e-09 ko04742 Taste transduction 23/707 61/7206 4.62319616672e-09 ko05030 Cocaine addiction 24/707 73/7206 4.84607447361e-08 ko04726 Serotonergic synapse 34/707 137/7206 2.25533595026e-07 ko05203 Viral carcinogenesis 6/707 277/7206 5.15014192677e-07 ko04921 Oxytocin signaling pathway 43/707 209/7206 2.36694311839e-06 ko04261 Adrenergic signaling in cardiomyocytes 42/707 205/7206 3.48489696095e-06 ko05031 Amphetamine addiction 24/707 91/7206 4.39583159554e-06 ko05205 Proteoglycans in cancer 7/707 271/7206 5.31445308502e-06 ko04514 Cell adhesion molecules (CAMs) 30/707 130/7206 7.13059142779e-06 ko04970 Salivary secretion 24/707 95/7206 9.84276042201e-06 ko04720 Long-term potentiation 24/707 99/7206 2.08377363191e-05 ko05164 Influenza A 3/707 167/7206 5.81538746714e-05 ko04972 Pancreatic secretion 25/707 111/7206 6.30522185236e-05 ko04072 Phospholipase D signaling pathway 37/707 197/7206 8.41331404739e-05 ko05162 Measles 1/707 120/7206 0.000129808096213 ko04022 cGMP-PKG signaling pathway 39/707 216/7206 0.000161568624855 ko04925 Aldosterone synthesis and secretion 23/707 105/7206 0.00018290960123 ko04971 Gastric acid secretion 22/707 98/7206 0.00019348623647 ko05322 Systemic lupus erythematosus 3/707 151/7206 0.000253056311981 ko03013 RNA transport 4/707 166/7206 0.000303896520274 ko04110 Cell cycle 3/707 145/7206 0.000359827255368 ko05014 Amyotrophic lateral sclerosis (ALS) 17/707 74/7206 0.000643839176394 ko05169 Epstein-Barr virus infection 7/707 206/7206 0.000759242659959 ko04976 Bile secretion 18/707 80/7206 0.000834932163812 ko04961 Endocrine and other factor-regulated calcium reabsorption 14/707 59/7206 0.00135613517302 ko04010 MAPK signaling pathway 49/707 321/7206 0.00145792848816 ko04740 Olfactory transduction 17/707 80/7206 0.0018733388328 ko04120 Ubiquitin mediated proteolysis 4/707 138/7206 0.00338718890711 ko00290 Valine, leucine and isoleucine biosynthesis 3/707 4/7206 0.00348745916681 ko04932 Non-alcoholic fatty liver disease (NAFLD) 7/707 182/7206 0.0035024927062 ko04540 Gap junction 23/707 128/7206 0.00387598554483 ko05131 Shigellosis 1/707 82/7206 0.00416096347315 ko04218 Cellular senescence 7/707 177/7206 0.00473376417549 ko04918 Thyroid hormone synthesis 17/707 86/7206 0.00503083922385 ko04964 Proximal tubule bicarbonate reclamation 8/707 29/7206 0.0054670894155 ko04612 Antigen processing and presentation 1/707 77/7206 0.00600074749825 ko05215 Prostate cancer 3/707 111/7206 0.00602379557211 ko04060 Cytokine-cytokine receptor interaction 8/707 191/7206 0.00620073684597 ko04710 Circadian rhythm 10/707 43/7206 0.00744360500907 ko04141 Protein processing in endoplasmic reticulum 8/707 184/7206 0.00812215627424 ko04750 Inflammatory mediator regulation of TRP channels 21/707 122/7206 0.00881984141676 ko04260 Cardiac muscle contraction 18/707 98/7206 0.00897203899798 ko04621 NOD-like receptor signaling pathway 6/707 157/7206 0.00914988486174 ko04730 Long-term depression 15/707 78/7206 0.010878289143 ko05168 Herpes simplex infection 8/707 182/7206 0.0109214007855 ko04915 Estrogen signaling pathway 22/707 131/7206 0.0109856769647 ko04068 FoxO signaling pathway 7/707 167/7206 0.0116100242032 ko04142 Lysosome 6/707 151/7206 0.0120498628712 ko04974 Protein digestion and absorption 17/707 96/7206 0.0144307852104 ko05212 Pancreatic cancer 2/707 83/7206 0.0153467334467 ko05218 Melanoma 2/707 85/7206 0.0155524255323 ko05220 Chronic myeloid leukemia 2/707 85/7206 0.0155524255323 ko04630 Jak-STAT signaling pathway 5/707 132/7206 0.0169534225938 ko04930 Type II diabetes mellitus 11/707 54/7206 0.0178940948653 ko04610 Complement and coagulation cascades 2/707 79/7206 0.0218183505821 ko04137 Mitophagy - animal 2/707 82/7206 0.0226433563689 ko05211 Renal cell carcinoma 3/707 96/7206 0.0232670272354 ko04650 Natural killer cell mediated cytotoxicity 3/707 97/7206 0.0235893175919 ko05132 Salmonella infection 3/707 98/7206 0.0240702980097 ko04217 Necroptosis 9/707 178/7206 0.0293468389641 ko04664 Fc epsilon RI signaling pathway 2/707 77/7206 0.0315629537376 ko04711 Circadian rhythm - fly 4/707 13/7206 0.0319739568113 ko04145 Phagosome 8/707 162/7206 0.0321253134484 ko04140 Autophagy - animal 8/707 164/7206 0.0324405933846 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 14/707 79/7206 0.0331579648875 ko04810 Regulation of actin cytoskeleton 16/707 264/7206 0.0348396548007 ko04070 Phosphatidylinositol signaling system 18/707 112/7206 0.0354188944086 ko05414 Dilated cardiomyopathy 18/707 112/7206 0.0354188944086 ko04380 Osteoclast differentiation 6/707 134/7206 0.0385145369466 ko05321 Inflammatory bowel disease (IBD) 1/707 56/7206 0.0399483040168 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/707 14/7206 0.0413836824152 ko04214 Apoptosis - fly 2/707 72/7206 0.0440891964972 ko00310 Lysine degradation 2/707 73/7206 0.0447568773992