ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	161/1033	423/7206	4.68239464083e-36
ko05033	Nicotine addiction	45/1033	56/7206	1.43137155274e-28
ko04724	Glutamatergic synapse	77/1033	152/7206	7.48190447749e-27
ko05032	Morphine addiction	61/1033	110/7206	3.25540788059e-24
ko04727	GABAergic synapse	59/1033	110/7206	1.86941606659e-22
ko04728	Dopaminergic synapse	79/1033	185/7206	1.77638043885e-21
ko04721	Synaptic vesicle cycle	48/1033	80/7206	2.6306935382e-21
ko04713	Circadian entrainment	63/1033	136/7206	1.52476546163e-19
ko04723	Retrograde endocannabinoid signaling	71/1033	175/7206	6.50883008309e-18
ko04725	Cholinergic synapse	67/1033	160/7206	8.00314142122e-18
ko04744	Phototransduction	27/1033	36/7206	3.17566605778e-16
ko04024	cAMP signaling pathway	90/1033	279/7206	7.9827654909e-15
ko04020	Calcium signaling pathway	82/1033	265/7206	1.55807984682e-12
ko04726	Serotonergic synapse	52/1033	137/7206	4.35420501753e-12
ko04921	Oxytocin signaling pathway	68/1033	209/7206	1.37985043139e-11
ko04742	Taste transduction	31/1033	61/7206	1.4228660895e-11
ko04261	Adrenergic signaling in cardiomyocytes	67/1033	205/7206	1.82089178954e-11
ko04911	Insulin secretion	45/1033	117/7206	7.37154993434e-11
ko05031	Amphetamine addiction	37/1033	91/7206	5.79851891909e-10
ko05203	Viral carcinogenesis	10/1033	277/7206	4.05087434811e-09
ko03040	Spliceosome	1/1033	145/7206	5.668156698e-09
ko04720	Long-term potentiation	35/1033	99/7206	1.17577561355e-07
ko04970	Salivary secretion	34/1033	95/7206	1.26626725815e-07
ko05030	Cocaine addiction	28/1033	73/7206	3.14383467479e-07
ko05164	Influenza A	5/1033	167/7206	1.63096707323e-06
ko04060	Cytokine-cytokine receptor interaction	7/1033	191/7206	1.65330951469e-06
ko05322	Systemic lupus erythematosus	4/1033	151/7206	1.75995976351e-06
ko04966	Collecting duct acid secretion	14/1033	26/7206	2.54100292611e-06
ko04514	Cell adhesion molecules (CAMs)	39/1033	130/7206	3.25645361006e-06
ko05168	Herpes simplex infection	7/1033	182/7206	4.8153569709e-06
ko04022	cGMP-PKG signaling pathway	56/1033	216/7206	6.68507339188e-06
ko04925	Aldosterone synthesis and secretion	33/1033	105/7206	6.92440438284e-06
ko03013	RNA transport	6/1033	166/7206	8.59420335902e-06
ko04120	Ubiquitin mediated proteolysis	4/1033	138/7206	1.17847664703e-05
ko04971	Gastric acid secretion	31/1033	98/7206	1.31352314198e-05
ko04621	NOD-like receptor signaling pathway	6/1033	157/7206	2.49625330424e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1033	79/7206	2.62476661535e-05
ko04010	MAPK signaling pathway	72/1033	321/7206	6.00126060327e-05
ko04924	Renin secretion	27/1033	86/7206	6.30981212226e-05
ko04964	Proximal tubule bicarbonate reclamation	13/1033	29/7206	7.26594542396e-05
ko04260	Cardiac muscle contraction	29/1033	98/7206	0.000105665565815
ko05161	Hepatitis B	9/1033	173/7206	0.000163832901094
ko04972	Pancreatic secretion	31/1033	111/7206	0.000170737826464
ko04070	Phosphatidylinositol signaling system	31/1033	112/7206	0.000191965905062
ko04740	Olfactory transduction	24/1033	80/7206	0.000285593753837
ko05169	Epstein-Barr virus infection	13/1033	206/7206	0.000376606164543
ko04360	Axon guidance	53/1033	233/7206	0.000412013150848
ko04110	Cell cycle	7/1033	145/7206	0.000430417986421
ko04745	Phototransduction - fly	14/1033	38/7206	0.000473775087501
ko04730	Long-term depression	23/1033	78/7206	0.000480790774
ko05414	Dilated cardiomyopathy	30/1033	112/7206	0.000541554488633
ko04064	NF-kappa B signaling pathway	3/1033	96/7206	0.000579793084542
ko05014	Amyotrophic lateral sclerosis (ALS)	22/1033	74/7206	0.000609075034061
ko05166	HTLV-I infection	23/1033	292/7206	0.00082996589942
ko04014	Ras signaling pathway	60/1033	279/7206	0.000885421465962
ko04612	Antigen processing and presentation	2/1033	77/7206	0.000941506812584
ko03008	Ribosome biogenesis in eukaryotes	2/1033	79/7206	0.000965065112542
ko04976	Bile secretion	23/1033	80/7206	0.00101414419133
ko05205	Proteoglycans in cancer	21/1033	271/7206	0.00101508036161
ko04141	Protein processing in endoplasmic reticulum	12/1033	184/7206	0.00127523766264
ko05140	Leishmaniasis	2/1033	75/7206	0.00137856491632
ko05162	Measles	6/1033	120/7206	0.00150246091851
ko04626	Plant-pathogen interaction	8/1033	18/7206	0.00199316796247
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1033	100/7206	0.00215733944283
ko05110	Vibrio cholerae infection	18/1033	63/7206	0.00312404609337
ko04072	Phospholipase D signaling pathway	43/1033	197/7206	0.00373739887118
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1033	59/7206	0.00406972823336
ko04610	Complement and coagulation cascades	3/1033	79/7206	0.00521482663212
ko04115	p53 signaling pathway	3/1033	74/7206	0.00706342327524
ko04915	Estrogen signaling pathway	30/1033	131/7206	0.00775524433227
ko04750	Inflammatory mediator regulation of TRP channels	28/1033	122/7206	0.00892527515661
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1033	14/7206	0.00917205572968
ko00290	Valine, leucine and isoleucine biosynthesis	3/1033	4/7206	0.0104936857912
ko03420	Nucleotide excision repair	1/1033	46/7206	0.0108019564715
ko04510	Focal adhesion	21/1033	240/7206	0.0111054435899
ko05219	Bladder cancer	1/1033	48/7206	0.0111807542683
ko04630	Jak-STAT signaling pathway	9/1033	132/7206	0.0115200334365
ko00240	Pyrimidine metabolism	7/1033	110/7206	0.0130996252819
ko05215	Prostate cancer	7/1033	111/7206	0.0132256040504
ko04146	Peroxisome	5/1033	89/7206	0.0143365662814
ko03022	Basal transcription factors	1/1033	44/7206	0.016079694699
ko05144	Malaria	1/1033	45/7206	0.0165060986481
ko04140	Autophagy - animal	13/1033	164/7206	0.0173119175176
ko04210	Apoptosis	15/1033	180/7206	0.0175722125811
ko04658	Th1 and Th2 cell differentiation	6/1033	96/7206	0.018689429902
ko00480	Glutathione metabolism	2/1033	55/7206	0.0189820158039
ko05321	Inflammatory bowel disease (IBD)	2/1033	56/7206	0.0194584642875
ko04540	Gap junction	28/1033	128/7206	0.0210073350936
ko04217	Necroptosis	15/1033	178/7206	0.0223818777011
ko05120	Epithelial cell signaling in Helicobacter pylori infection	21/1033	92/7206	0.0244093508272
ko04710	Circadian rhythm	12/1033	43/7206	0.0254636492846
ko03018	RNA degradation	5/1033	84/7206	0.0269911615614
ko00590	Arachidonic acid metabolism	2/1033	52/7206	0.0272600712521
ko04214	Apoptosis - fly	4/1033	72/7206	0.0278472841029
ko00310	Lysine degradation	4/1033	73/7206	0.0279347202712
ko04622	RIG-I-like receptor signaling pathway	3/1033	62/7206	0.0281696354137
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1033	182/7206	0.0315127067061
ko00562	Inositol phosphate metabolism	20/1033	89/7206	0.0329419289824
ko04668	TNF signaling pathway	9/1033	120/7206	0.0343327896686
ko04137	Mitophagy - animal	5/1033	82/7206	0.0373555079162
ko05206	MicroRNAs in cancer	16/1033	177/7206	0.0392524101858
ko05145	Toxoplasmosis	10/1033	126/7206	0.0394158399266
ko04657	IL-17 signaling pathway	6/1033	87/7206	0.0450917835746
ko05133	Pertussis	6/1033	87/7206	0.0450917835746
ko05222	Small cell lung cancer	6/1033	89/7206	0.0459867456785
ko04371	Apelin signaling pathway	35/1033	177/7206	0.0496142424209
ko04930	Type II diabetes mellitus	13/1033	54/7206	0.0498331609309