ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	184/1148	423/7206	2.28494687544e-44
ko05033	Nicotine addiction	46/1148	56/7206	6.47684409322e-28
ko04724	Glutamatergic synapse	82/1148	152/7206	9.48146458823e-28
ko05032	Morphine addiction	67/1148	110/7206	4.62411842578e-27
ko04727	GABAergic synapse	63/1148	110/7206	1.92609455378e-23
ko04713	Circadian entrainment	70/1148	136/7206	3.02757787695e-22
ko04728	Dopaminergic synapse	81/1148	185/7206	7.71684122335e-20
ko04725	Cholinergic synapse	72/1148	160/7206	1.45310843542e-18
ko04723	Retrograde endocannabinoid signaling	75/1148	175/7206	8.50838385243e-18
ko04721	Synaptic vesicle cycle	46/1148	80/7206	1.58543806972e-17
ko04024	cAMP signaling pathway	100/1148	279/7206	9.74005173453e-17
ko04744	Phototransduction	27/1148	36/7206	4.8333240034e-15
ko04020	Calcium signaling pathway	91/1148	265/7206	6.09606782142e-14
ko04726	Serotonergic synapse	57/1148	137/7206	3.84227534042e-13
ko04742	Taste transduction	34/1148	61/7206	9.4841412553e-13
ko04261	Adrenergic signaling in cardiomyocytes	72/1148	205/7206	9.18154889039e-12
ko04921	Oxytocin signaling pathway	72/1148	209/7206	3.20935317902e-11
ko04911	Insulin secretion	48/1148	117/7206	5.2129047214e-11
ko03040	Spliceosome	1/1148	145/7206	5.22000109765e-10
ko05031	Amphetamine addiction	38/1148	91/7206	2.99243624528e-09
ko03010	Ribosome	1/1148	129/7206	6.65906746971e-09
ko04720	Long-term potentiation	37/1148	99/7206	1.88894541235e-07
ko05322	Systemic lupus erythematosus	4/1148	151/7206	2.10877156851e-07
ko04970	Salivary secretion	36/1148	95/7206	2.16852930112e-07
ko04070	Phosphatidylinositol signaling system	39/1148	112/7206	7.01351728425e-07
ko05030	Cocaine addiction	29/1148	73/7206	7.93607991578e-07
ko03013	RNA transport	6/1148	166/7206	8.11113020474e-07
ko05203	Viral carcinogenesis	17/1148	277/7206	8.81888079275e-07
ko04925	Aldosterone synthesis and secretion	37/1148	105/7206	1.09991942443e-06
ko04022	cGMP-PKG signaling pathway	62/1148	216/7206	1.64164214825e-06
ko04060	Cytokine-cytokine receptor interaction	9/1148	191/7206	1.76161649764e-06
ko05168	Herpes simplex infection	9/1148	182/7206	7.36518224076e-06
ko04514	Cell adhesion molecules (CAMs)	40/1148	130/7206	1.74006860377e-05
ko04971	Gastric acid secretion	33/1148	98/7206	1.74996302693e-05
ko05164	Influenza A	9/1148	167/7206	3.86971612276e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1148	74/7206	4.12798766309e-05
ko04360	Axon guidance	61/1148	233/7206	5.23320895518e-05
ko04966	Collecting duct acid secretion	13/1148	26/7206	5.39072965706e-05
ko04010	MAPK signaling pathway	78/1148	321/7206	6.46687465857e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1148	79/7206	6.50785593109e-05
ko04972	Pancreatic secretion	34/1148	111/7206	0.000108385026981
ko04120	Ubiquitin mediated proteolysis	7/1148	138/7206	0.000137052608652
ko04924	Renin secretion	28/1148	86/7206	0.000140028737601
ko04072	Phospholipase D signaling pathway	52/1148	197/7206	0.000150269939481
ko04964	Proximal tubule bicarbonate reclamation	13/1148	29/7206	0.000220070968579
ko03008	Ribosome biogenesis in eukaryotes	2/1148	79/7206	0.000268956335388
ko05414	Dilated cardiomyopathy	33/1148	112/7206	0.000348392553941
ko04621	NOD-like receptor signaling pathway	10/1148	157/7206	0.00037708287069
ko05140	Leishmaniasis	2/1148	75/7206	0.000387701555088
ko04014	Ras signaling pathway	67/1148	279/7206	0.000420329465682
ko04730	Long-term depression	25/1148	78/7206	0.000444865812748
ko04141	Protein processing in endoplasmic reticulum	13/1148	184/7206	0.000461695895381
ko04740	Olfactory transduction	25/1148	80/7206	0.000562237671775
ko04260	Cardiac muscle contraction	29/1148	98/7206	0.000679814871931
ko05205	Proteoglycans in cancer	24/1148	271/7206	0.000681892003563
ko04930	Type II diabetes mellitus	18/1148	54/7206	0.00128104049172
ko04745	Phototransduction - fly	14/1148	38/7206	0.00139447083195
ko04612	Antigen processing and presentation	3/1148	77/7206	0.00153401459136
ko04915	Estrogen signaling pathway	35/1148	131/7206	0.00153499366984
ko04750	Inflammatory mediator regulation of TRP channels	33/1148	122/7206	0.00160657658158
ko04610	Complement and coagulation cascades	3/1148	79/7206	0.00161392988045
ko04064	NF-kappa B signaling pathway	5/1148	96/7206	0.00185123921712
ko04923	Regulation of lipolysis in adipocytes	23/1148	77/7206	0.00241674673955
ko04976	Bile secretion	23/1148	80/7206	0.00320034438937
ko00562	Inositol phosphate metabolism	25/1148	89/7206	0.00320483575379
ko05162	Measles	8/1148	120/7206	0.00351167463585
ko05169	Epstein-Barr virus infection	18/1148	206/7206	0.00354881592476
ko00240	Pyrimidine metabolism	7/1148	110/7206	0.00361092069889
ko04110	Cell cycle	11/1148	145/7206	0.00392568576183
ko04626	Plant-pathogen interaction	8/1148	18/7206	0.00396089560591
ko05110	Vibrio cholerae infection	19/1148	63/7206	0.00473167939867
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1148	100/7206	0.00532177655031
ko05161	Hepatitis B	15/1148	173/7206	0.00613594988808
ko04371	Apelin signaling pathway	42/1148	177/7206	0.00653466861892
ko03022	Basal transcription factors	1/1148	44/7206	0.00676899450754
ko05144	Malaria	1/1148	45/7206	0.00679913090904
ko00071	Fatty acid degradation	1/1148	45/7206	0.00679913090904
ko04658	Th1 and Th2 cell differentiation	6/1148	96/7206	0.00703729593205
ko04540	Gap junction	32/1148	128/7206	0.00705092414596
ko03420	Nucleotide excision repair	1/1148	46/7206	0.00706585914166
ko00480	Glutathione metabolism	2/1148	55/7206	0.00853724634544
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1148	59/7206	0.011282758457
ko00590	Arachidonic acid metabolism	2/1148	52/7206	0.0123368371355
ko04146	Peroxisome	6/1148	89/7206	0.0130200132284
ko04622	RIG-I-like receptor signaling pathway	3/1148	62/7206	0.0134989211755
ko05131	Shigellosis	5/1148	82/7206	0.0139808253472
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1148	14/7206	0.0153099082059
ko05231	Choline metabolism in cancer	32/1148	134/7206	0.0164622653682
ko04217	Necroptosis	17/1148	178/7206	0.016784436921
ko04657	IL-17 signaling pathway	6/1148	87/7206	0.0177091699916
ko05133	Pertussis	6/1148	87/7206	0.0177091699916
ko04710	Circadian rhythm	13/1148	43/7206	0.0187809345002
ko03410	Base excision repair	1/1148	38/7206	0.0232550520093
ko03018	RNA degradation	6/1148	84/7206	0.0239433899578
ko05145	Toxoplasmosis	11/1148	126/7206	0.0262668376971
ko05219	Bladder cancer	2/1148	48/7206	0.0268040363562
ko05321	Inflammatory bowel disease (IBD)	3/1148	56/7206	0.0268195354235
ko05166	HTLV-I infection	33/1148	292/7206	0.0272735197111
ko04960	Aldosterone-regulated sodium reabsorption	12/1148	41/7206	0.0295518056189
ko04210	Apoptosis	18/1148	180/7206	0.0296545467853
ko04973	Carbohydrate digestion and absorption	12/1148	42/7206	0.0331408124554
ko00860	Porphyrin and chlorophyll metabolism	1/1148	34/7206	0.0334920002845
ko04214	Apoptosis - fly	5/1148	72/7206	0.0346588012256
ko00310	Lysine degradation	5/1148	73/7206	0.035051008237
ko00280	Valine, leucine and isoleucine degradation	3/1148	54/7206	0.0380762837737
ko04711	Circadian rhythm - fly	5/1148	13/7206	0.0429570108037
ko03320	PPAR signaling pathway	5/1148	69/7206	0.0469630190463
ko04510	Focal adhesion	27/1148	240/7206	0.0479148913213
ko04722	Neurotrophin signaling pathway	35/1148	160/7206	0.0483246258001