ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 45/323 152/7206 1.32263519862e-25 ko04080 Neuroactive ligand-receptor interaction 69/323 423/7206 3.18732560976e-22 ko05033 Nicotine addiction 26/323 56/7206 6.34261692882e-21 ko04727 GABAergic synapse 31/323 110/7206 3.37356315455e-17 ko04723 Retrograde endocannabinoid signaling 36/323 175/7206 4.94648128549e-15 ko04713 Circadian entrainment 29/323 136/7206 9.94464437164e-13 ko05032 Morphine addiction 26/323 110/7206 1.25137679317e-12 ko04728 Dopaminergic synapse 33/323 185/7206 4.93589665509e-12 ko04020 Calcium signaling pathway 38/323 265/7206 1.06471112723e-10 ko05031 Amphetamine addiction 21/323 91/7206 3.18785033744e-10 ko05030 Cocaine addiction 18/323 73/7206 1.93618891432e-09 ko04720 Long-term potentiation 20/323 99/7206 1.01248685575e-08 ko04730 Long-term depression 15/323 78/7206 1.43352250933e-06 ko04742 Taste transduction 13/323 61/7206 2.1681520123e-06 ko04725 Cholinergic synapse 22/323 160/7206 2.25995363359e-06 ko04726 Serotonergic synapse 20/323 137/7206 2.57556040871e-06 ko04010 MAPK signaling pathway 33/323 321/7206 6.04087041247e-06 ko04721 Synaptic vesicle cycle 14/323 80/7206 1.02552446073e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 13/323 74/7206 2.03923124801e-05 ko04911 Insulin secretion 16/323 117/7206 5.96772458166e-05 ko04024 cAMP signaling pathway 28/323 279/7206 7.84161739317e-05 ko04921 Oxytocin signaling pathway 22/323 209/7206 0.000215393956187 ko04072 Phospholipase D signaling pathway 21/323 197/7206 0.000289064583921 ko04970 Salivary secretion 13/323 95/7206 0.000290789116479 ko04261 Adrenergic signaling in cardiomyocytes 21/323 205/7206 0.000391959455619 ko05203 Viral carcinogenesis 2/323 277/7206 0.000511416009642 ko05231 Choline metabolism in cancer 15/323 134/7206 0.00091936422269 ko05169 Epstein-Barr virus infection 1/323 206/7206 0.00163325937005 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 10/323 79/7206 0.00261589523099 ko05168 Herpes simplex infection 1/323 182/7206 0.00335713837538 ko04141 Protein processing in endoplasmic reticulum 1/323 184/7206 0.00335978403783 ko04972 Pancreatic secretion 12/323 111/7206 0.00391197692662 ko04022 cGMP-PKG signaling pathway 19/323 216/7206 0.00415999102593 ko04070 Phosphatidylinositol signaling system 12/323 112/7206 0.00421013700759 ko05414 Dilated cardiomyopathy 12/323 112/7206 0.00421013700759 ko04217 Necroptosis 1/323 178/7206 0.00497705602015 ko04925 Aldosterone synthesis and secretion 11/323 105/7206 0.00713452256799 ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series 5/323 28/7206 0.00736090595942 ko04930 Type II diabetes mellitus 7/323 54/7206 0.00984481377955 ko04260 Cardiac muscle contraction 10/323 98/7206 0.012046495977 ko05410 Hypertrophic cardiomyopathy (HCM) 10/323 100/7206 0.0137681825341 ko04540 Gap junction 12/323 128/7206 0.0146465031154 ko04142 Lysosome 1/323 151/7206 0.0151340472246 ko04514 Cell adhesion molecules (CAMs) 12/323 130/7206 0.0158698983892 ko04915 Estrogen signaling pathway 12/323 131/7206 0.0165390169023 ko04014 Ras signaling pathway 21/323 279/7206 0.0175232833431 ko00562 Inositol phosphate metabolism 9/323 89/7206 0.0177458457157 ko04110 Cell cycle 1/323 145/7206 0.0225671595428 ko04666 Fc gamma R-mediated phagocytosis 11/323 122/7206 0.0241057311864 ko05034 Alcoholism 18/323 238/7206 0.0253236088803 ko04740 Olfactory transduction 8/323 80/7206 0.0262279913292 ko00650 Butanoate metabolism 4/323 26/7206 0.0271502460441 ko04630 Jak-STAT signaling pathway 1/323 132/7206 0.0312626967686 ko05164 Influenza A 2/323 167/7206 0.0351275621282 ko00512 Mucin type O-glycan biosynthesis 4/323 29/7206 0.038862184428 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/323 1/7206 0.0448237579796 ko00190 Oxidative phosphorylation 1/323 127/7206 0.0466180291315