ko pathway ratio_in_study ratio_in_pop p_value ko05033 Nicotine addiction 23/287 56/7206 2.58547960705e-18 ko04724 Glutamatergic synapse 35/287 152/7206 6.77488437392e-18 ko04728 Dopaminergic synapse 32/287 185/7206 1.00082290917e-12 ko04080 Neuroactive ligand-receptor interaction 50/287 423/7206 1.45776805681e-12 ko04721 Synaptic vesicle cycle 19/287 80/7206 1.80727373162e-10 ko04727 GABAergic synapse 22/287 110/7206 2.31727448863e-10 ko04713 Circadian entrainment 23/287 136/7206 2.90213251356e-09 ko04723 Retrograde endocannabinoid signaling 26/287 175/7206 4.60087674381e-09 ko04514 Cell adhesion molecules (CAMs) 22/287 130/7206 6.41720229771e-09 ko05030 Cocaine addiction 16/287 73/7206 1.79192492996e-08 ko05031 Amphetamine addiction 17/287 91/7206 7.96116014297e-08 ko05032 Morphine addiction 17/287 110/7206 1.34681070575e-06 ko04020 Calcium signaling pathway 28/287 265/7206 1.88808700917e-06 ko04024 cAMP signaling pathway 28/287 279/7206 5.19829028899e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 13/287 74/7206 5.69323043606e-06 ko04010 MAPK signaling pathway 30/287 321/7206 1.15610282312e-05 ko04261 Adrenergic signaling in cardiomyocytes 22/287 205/7206 1.96040742696e-05 ko04720 Long-term potentiation 14/287 99/7206 3.30897156874e-05 ko04911 Insulin secretion 15/287 117/7206 5.63109437874e-05 ko04742 Taste transduction 10/287 61/7206 0.000127636617975 ko04725 Cholinergic synapse 17/287 160/7206 0.000197864992411 ko04360 Axon guidance 22/287 233/7206 0.00020345091409 ko05203 Viral carcinogenesis 1/287 277/7206 0.000233849248109 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 11/287 79/7206 0.000266548662943 ko04921 Oxytocin signaling pathway 19/287 209/7206 0.000812117204295 ko05414 Dilated cardiomyopathy 12/287 112/7206 0.00158592339809 ko04260 Cardiac muscle contraction 11/287 98/7206 0.00169092243542 ko05410 Hypertrophic cardiomyopathy (HCM) 11/287 100/7206 0.00199224015651 ko05169 Epstein-Barr virus infection 1/287 206/7206 0.00338420076352 ko04730 Long-term depression 9/287 78/7206 0.00363234272355 ko04970 Salivary secretion 10/287 95/7206 0.00434702135955 ko04915 Estrogen signaling pathway 12/287 131/7206 0.00582847635593 ko05168 Herpes simplex infection 1/287 182/7206 0.0107446703681 ko04141 Protein processing in endoplasmic reticulum 1/287 184/7206 0.0110132375282 ko05231 Choline metabolism in cancer 12/287 134/7206 0.0110600523871 ko04726 Serotonergic synapse 12/287 137/7206 0.0118865482477 ko04972 Pancreatic secretion 10/287 111/7206 0.0127233564621 ko05164 Influenza A 1/287 167/7206 0.0150419547329 ko05010 Alzheimer's disease 15/287 202/7206 0.0169718573961 ko04022 cGMP-PKG signaling pathway 16/287 216/7206 0.0192420036692 ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series 4/287 28/7206 0.0237361028007 ko00513 Various types of N-glycan biosynthesis 5/287 42/7206 0.0246621965656 ko00230 Purine metabolism 2/287 194/7206 0.0249591888354 ko04110 Cell cycle 1/287 145/7206 0.0312314159963 ko04150 mTOR signaling pathway 2/287 184/7206 0.034987220367 ko04919 Thyroid hormone signaling pathway 1/287 143/7206 0.0469744940459 ko05161 Hepatitis B 2/287 173/7206 0.0488667939185 ko04217 Necroptosis 2/287 178/7206 0.0494331758344