ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	208/1300	423/7206	7.66501790597e-52
ko04724	Glutamatergic synapse	93/1300	152/7206	6.48530863176e-33
ko05033	Nicotine addiction	47/1300	56/7206	7.72649807423e-27
ko05032	Morphine addiction	70/1300	110/7206	1.70083931358e-26
ko04727	GABAergic synapse	69/1300	110/7206	1.39125966694e-25
ko04713	Circadian entrainment	78/1300	136/7206	3.95639594504e-25
ko04721	Synaptic vesicle cycle	53/1300	80/7206	1.52115893577e-21
ko04725	Cholinergic synapse	80/1300	160/7206	1.29652347745e-20
ko04728	Dopaminergic synapse	85/1300	185/7206	8.04947020278e-19
ko04723	Retrograde endocannabinoid signaling	80/1300	175/7206	1.29645408034e-17
ko04020	Calcium signaling pathway	104/1300	265/7206	1.39393457157e-16
ko04911	Insulin secretion	60/1300	117/7206	2.03641751115e-16
ko04024	cAMP signaling pathway	106/1300	279/7206	9.99781330439e-16
ko04726	Serotonergic synapse	65/1300	137/7206	1.63928266105e-15
ko04742	Taste transduction	39/1300	61/7206	2.16544835033e-15
ko04921	Oxytocin signaling pathway	83/1300	209/7206	7.98866704275e-14
ko04744	Phototransduction	26/1300	36/7206	1.46166268877e-12
ko04720	Long-term potentiation	47/1300	99/7206	1.39628104653e-11
ko03040	Spliceosome	1/1300	145/7206	1.62223445722e-11
ko05031	Amphetamine addiction	43/1300	91/7206	1.2623096738e-10
ko04970	Salivary secretion	44/1300	95/7206	1.75055668752e-10
ko04740	Olfactory transduction	39/1300	80/7206	2.87842091373e-10
ko04261	Adrenergic signaling in cardiomyocytes	72/1300	205/7206	3.06763566601e-09
ko04360	Axon guidance	78/1300	233/7206	9.78394065172e-09
ko03013	RNA transport	7/1300	166/7206	1.0938963814e-07
ko04925	Aldosterone synthesis and secretion	42/1300	105/7206	1.09866293787e-07
ko04022	cGMP-PKG signaling pathway	71/1300	216/7206	1.1518902995e-07
ko05168	Herpes simplex infection	9/1300	182/7206	2.28602105746e-07
ko04971	Gastric acid secretion	39/1300	98/7206	3.78627261488e-07
ko04621	NOD-like receptor signaling pathway	7/1300	157/7206	4.95670343139e-07
ko04540	Gap junction	46/1300	128/7206	1.14333356834e-06
ko05322	Systemic lupus erythematosus	7/1300	151/7206	1.56927408813e-06
ko05164	Influenza A	9/1300	167/7206	1.94650733376e-06
ko04972	Pancreatic secretion	40/1300	111/7206	4.98136704065e-06
ko04966	Collecting duct acid secretion	15/1300	26/7206	6.76584746274e-06
ko04730	Long-term depression	31/1300	78/7206	8.26123651769e-06
ko04060	Cytokine-cytokine receptor interaction	13/1300	191/7206	9.05865262665e-06
ko04120	Ubiquitin mediated proteolysis	7/1300	138/7206	9.42032660191e-06
ko05203	Viral carcinogenesis	24/1300	277/7206	1.01503828279e-05
ko05030	Cocaine addiction	29/1300	73/7206	1.0992977378e-05
ko04514	Cell adhesion molecules (CAMs)	44/1300	130/7206	1.4099181797e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1300	74/7206	2.08893122267e-05
ko04141	Protein processing in endoplasmic reticulum	13/1300	184/7206	2.40182832102e-05
ko04924	Renin secretion	32/1300	86/7206	2.52490203541e-05
ko05169	Epstein-Barr virus infection	16/1300	206/7206	2.99967378339e-05
ko04010	MAPK signaling pathway	87/1300	321/7206	3.98812575311e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1300	79/7206	4.46027914921e-05
ko04014	Ras signaling pathway	77/1300	279/7206	6.35862405602e-05
ko04976	Bile secretion	29/1300	80/7206	9.82376756281e-05
ko04070	Phosphatidylinositol signaling system	37/1300	112/7206	0.000104246676891
ko04745	Phototransduction - fly	17/1300	38/7206	0.00012742670166
ko04072	Phospholipase D signaling pathway	57/1300	197/7206	0.000149721931687
ko04110	Cell cycle	10/1300	145/7206	0.000173027100393
ko04750	Inflammatory mediator regulation of TRP channels	39/1300	122/7206	0.000186492301131
ko04146	Peroxisome	4/1300	89/7206	0.000243969146787
ko00520	Amino sugar and nucleotide sugar metabolism	1/1300	55/7206	0.000330800191718
ko04371	Apelin signaling pathway	51/1300	177/7206	0.000339375170482
ko04064	NF-kappa B signaling pathway	5/1300	96/7206	0.000408771010336
ko05110	Vibrio cholerae infection	23/1300	63/7206	0.000426020720412
ko05140	Leishmaniasis	3/1300	75/7206	0.000431253209779
ko05162	Measles	8/1300	120/7206	0.000454142922093
ko04612	Antigen processing and presentation	3/1300	77/7206	0.000457101618664
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1300	59/7206	0.000461460542504
ko04260	Cardiac muscle contraction	32/1300	98/7206	0.000471294252247
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1300	79/7206	0.000558860133397
ko05414	Dilated cardiomyopathy	35/1300	112/7206	0.000696427757176
ko04964	Proximal tubule bicarbonate reclamation	13/1300	29/7206	0.000775251657387
ko04916	Melanogenesis	41/1300	142/7206	0.00129680144586
ko03420	Nucleotide excision repair	1/1300	46/7206	0.00176465398423
ko05145	Toxoplasmosis	10/1300	126/7206	0.00214189535631
ko04710	Circadian rhythm	16/1300	43/7206	0.00245038711469
ko03022	Basal transcription factors	1/1300	44/7206	0.00267294398323
ko00071	Fatty acid degradation	1/1300	45/7206	0.00275082392678
ko00310	Lysine degradation	4/1300	73/7206	0.00317400031649
ko05131	Shigellosis	5/1300	82/7206	0.00337736034757
ko05161	Hepatitis B	17/1300	173/7206	0.00351225435081
ko05205	Proteoglycans in cancer	31/1300	271/7206	0.00360513318155
ko04915	Estrogen signaling pathway	37/1300	131/7206	0.00385743709462
ko04270	Vascular smooth muscle contraction	42/1300	154/7206	0.00404750493571
ko04622	RIG-I-like receptor signaling pathway	3/1300	62/7206	0.0041759021388
ko04923	Regulation of lipolysis in adipocytes	24/1300	77/7206	0.00438848503307
ko05133	Pertussis	6/1300	87/7206	0.00459162934282
ko04922	Glucagon signaling pathway	36/1300	128/7206	0.00500043818875
ko00240	Pyrimidine metabolism	9/1300	110/7206	0.00553717859918
ko03018	RNA degradation	6/1300	84/7206	0.00631818499865
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1300	14/7206	0.00643948502829
ko04930	Type II diabetes mellitus	18/1300	54/7206	0.006686538501
ko04217	Necroptosis	19/1300	178/7206	0.00762505713682
ko04626	Plant-pathogen interaction	8/1300	18/7206	0.00866093255293
ko00630	Glyoxylate and dicarboxylate metabolism	1/1300	38/7206	0.00944802583534
ko04658	Th1 and Th2 cell differentiation	8/1300	96/7206	0.0106203389057
ko04657	IL-17 signaling pathway	7/1300	87/7206	0.0113360900177
ko04610	Complement and coagulation cascades	6/1300	79/7206	0.0119672440764
ko00280	Valine, leucine and isoleucine degradation	3/1300	54/7206	0.0122874429079
ko04912	GnRH signaling pathway	33/1300	122/7206	0.0123019826682
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1300	100/7206	0.0124861623355
ko04330	Notch signaling pathway	4/1300	62/7206	0.0126078796244
ko04960	Aldosterone-regulated sodium reabsorption	14/1300	41/7206	0.0127715370884
ko04015	Rap1 signaling pathway	66/1300	278/7206	0.0136388177246
ko05231	Choline metabolism in cancer	35/1300	134/7206	0.0171597723996
ko04620	Toll-like receptor signaling pathway	9/1300	100/7206	0.0175914021498
ko00860	Porphyrin and chlorophyll metabolism	1/1300	34/7206	0.0221266501038
ko04630	Jak-STAT signaling pathway	14/1300	132/7206	0.0222818703858
ko04115	p53 signaling pathway	6/1300	74/7206	0.0222983621066
ko05132	Salmonella infection	9/1300	98/7206	0.0234809561178
ko04210	Apoptosis	21/1300	180/7206	0.0236520792722
ko05166	HTLV-I infection	38/1300	292/7206	0.0239349966907
ko05214	Glioma	22/1300	79/7206	0.0272677613429
ko04214	Apoptosis - fly	6/1300	72/7206	0.0302682581745
ko05340	Primary immunodeficiency	1/1300	30/7206	0.0313626100486
ko04142	Lysosome	17/1300	151/7206	0.0316832009258
ko05321	Inflammatory bowel disease (IBD)	4/1300	56/7206	0.0346740523559
ko03410	Base excision repair	2/1300	38/7206	0.0349410505553
ko04932	Non-alcoholic fatty liver disease (NAFLD)	22/1300	182/7206	0.0396502219174
ko04113	Meiosis - yeast	6/1300	70/7206	0.0410158842367
ko04973	Carbohydrate digestion and absorption	13/1300	42/7206	0.0414644643456
ko00330	Arginine and proline metabolism	5/1300	61/7206	0.0443481358994
ko04213	Longevity regulating pathway - multiple species	23/1300	86/7206	0.0467623629098
ko04918	Thyroid hormone synthesis	23/1300	86/7206	0.0467623629098
ko01524	Platinum drug resistance	7/1300	76/7206	0.0498000686875