ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	180/1080	423/7206	9.63204022923e-46
ko04724	Glutamatergic synapse	91/1080	152/7206	7.80225569933e-38
ko05033	Nicotine addiction	48/1080	56/7206	4.63515365872e-32
ko04713	Circadian entrainment	77/1080	136/7206	8.26938202054e-30
ko05032	Morphine addiction	68/1080	110/7206	1.14560739601e-29
ko04727	GABAergic synapse	66/1080	110/7206	1.00304706696e-27
ko04728	Dopaminergic synapse	88/1080	185/7206	1.56037655524e-26
ko04725	Cholinergic synapse	77/1080	160/7206	1.00489455315e-23
ko04911	Insulin secretion	60/1080	117/7206	1.74312826824e-20
ko04723	Retrograde endocannabinoid signaling	76/1080	175/7206	4.88914809165e-20
ko04024	cAMP signaling pathway	101/1080	279/7206	3.19994552453e-19
ko04921	Oxytocin signaling pathway	79/1080	209/7206	1.76050964105e-16
ko05031	Amphetamine addiction	47/1080	91/7206	1.83077394266e-16
ko04726	Serotonergic synapse	60/1080	137/7206	2.92731118882e-16
ko04721	Synaptic vesicle cycle	43/1080	80/7206	5.3023358479e-16
ko04020	Calcium signaling pathway	91/1080	265/7206	1.08320458455e-15
ko04261	Adrenergic signaling in cardiomyocytes	76/1080	205/7206	2.35256848228e-15
ko04720	Long-term potentiation	46/1080	99/7206	6.45395077711e-14
ko05030	Cocaine addiction	37/1080	73/7206	6.66389073361e-13
ko04742	Taste transduction	33/1080	61/7206	1.10156501654e-12
ko04925	Aldosterone synthesis and secretion	44/1080	105/7206	1.82894988717e-11
ko04971	Gastric acid secretion	42/1080	98/7206	2.19773466952e-11
ko04744	Phototransduction	23/1080	36/7206	2.8909940147e-11
ko04970	Salivary secretion	40/1080	95/7206	1.28364552229e-10
ko03040	Spliceosome	1/1080	145/7206	2.18456562685e-09
ko04010	MAPK signaling pathway	87/1080	321/7206	8.6197290743e-09
ko04972	Pancreatic secretion	39/1080	111/7206	1.060855074e-07
ko04360	Axon guidance	65/1080	233/7206	2.954081305e-07
ko04022	cGMP-PKG signaling pathway	61/1080	216/7206	3.3371573429e-07
ko04072	Phospholipase D signaling pathway	56/1080	197/7206	8.23903902307e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1080	74/7206	1.10679958385e-06
ko04070	Phosphatidylinositol signaling system	37/1080	112/7206	1.37658071271e-06
ko05168	Herpes simplex infection	7/1080	182/7206	1.52382407726e-06
ko04540	Gap junction	40/1080	128/7206	2.34870471553e-06
ko04060	Cytokine-cytokine receptor interaction	8/1080	191/7206	2.56033446351e-06
ko04730	Long-term depression	28/1080	78/7206	3.73839841907e-06
ko05322	Systemic lupus erythematosus	5/1080	151/7206	4.5663836235e-06
ko04915	Estrogen signaling pathway	40/1080	131/7206	5.19808764613e-06
ko05203	Viral carcinogenesis	17/1080	277/7206	6.38515646755e-06
ko04740	Olfactory transduction	28/1080	80/7206	8.6927751753e-06
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1080	59/7206	2.04308099444e-05
ko04745	Phototransduction - fly	16/1080	38/7206	4.92783847841e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1080	79/7206	5.01849041674e-05
ko03013	RNA transport	8/1080	166/7206	5.81188849336e-05
ko04141	Protein processing in endoplasmic reticulum	10/1080	184/7206	6.00061127264e-05
ko05414	Dilated cardiomyopathy	33/1080	112/7206	7.86398538767e-05
ko04260	Cardiac muscle contraction	30/1080	98/7206	7.93443538089e-05
ko04612	Antigen processing and presentation	1/1080	77/7206	7.98373262827e-05
ko04610	Complement and coagulation cascades	1/1080	79/7206	8.53067923343e-05
ko04750	Inflammatory mediator regulation of TRP channels	35/1080	122/7206	9.19975317774e-05
ko04514	Cell adhesion molecules (CAMs)	36/1080	130/7206	0.000159105602804
ko04912	GnRH signaling pathway	34/1080	122/7206	0.000265914371647
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1080	14/7206	0.000320331435108
ko04621	NOD-like receptor signaling pathway	9/1080	157/7206	0.000407574349426
ko04110	Cell cycle	8/1080	145/7206	0.000565990417893
ko03008	Ribosome biogenesis in eukaryotes	2/1080	79/7206	0.000648780199025
ko04924	Renin secretion	25/1080	86/7206	0.000690193601185
ko04918	Thyroid hormone synthesis	25/1080	86/7206	0.000690193601185
ko04976	Bile secretion	24/1080	80/7206	0.000696091163523
ko04015	Rap1 signaling pathway	62/1080	278/7206	0.00105318860309
ko04916	Melanogenesis	36/1080	142/7206	0.001181682224
ko05164	Influenza A	11/1080	167/7206	0.00132209666226
ko04371	Apelin signaling pathway	42/1080	177/7206	0.00184759888618
ko04923	Regulation of lipolysis in adipocytes	22/1080	77/7206	0.00194282897413
ko00520	Amino sugar and nucleotide sugar metabolism	1/1080	55/7206	0.00210938915751
ko05016	Huntington's disease	17/1080	215/7206	0.00246839002612
ko00240	Pyrimidine metabolism	6/1080	110/7206	0.00279025160396
ko04114	Oocyte meiosis	34/1080	139/7206	0.0036253969558
ko04064	NF-kappa B signaling pathway	5/1080	96/7206	0.00381967090285
ko04640	Hematopoietic cell lineage	2/1080	64/7206	0.0041968431218
ko00310	Lysine degradation	3/1080	73/7206	0.00480877494391
ko03018	RNA degradation	4/1080	84/7206	0.00517464812402
ko05169	Epstein-Barr virus infection	17/1080	206/7206	0.00527594387043
ko05205	Proteoglycans in cancer	25/1080	271/7206	0.00538690827727
ko04960	Aldosterone-regulated sodium reabsorption	13/1080	41/7206	0.00655235947091
ko00562	Inositol phosphate metabolism	23/1080	89/7206	0.00665599902108
ko05034	Alcoholism	51/1080	238/7206	0.00713239267177
ko04964	Proximal tubule bicarbonate reclamation	10/1080	29/7206	0.0072593089572
ko04711	Circadian rhythm - fly	6/1080	13/7206	0.00744695013981
ko04350	TGF-beta signaling pathway	6/1080	103/7206	0.00751606973242
ko04014	Ras signaling pathway	58/1080	279/7206	0.00780949489758
ko00515	Mannose type O-glycan biosynthesis	9/1080	25/7206	0.00782305810476
ko04062	Chemokine signaling pathway	44/1080	201/7206	0.00877856511318
ko05162	Measles	8/1080	120/7206	0.00921009778108
ko04146	Peroxisome	5/1080	89/7206	0.0102702310477
ko00071	Fatty acid degradation	1/1080	45/7206	0.0105714641265
ko03420	Nucleotide excision repair	1/1080	46/7206	0.0109246968419
ko04142	Lysosome	12/1080	151/7206	0.0111576358448
ko04270	Vascular smooth muscle contraction	35/1080	154/7206	0.0114549492052
ko05110	Vibrio cholerae infection	17/1080	63/7206	0.0120812154292
ko04930	Type II diabetes mellitus	15/1080	54/7206	0.012555421919
ko00480	Glutathione metabolism	2/1080	55/7206	0.0127724255835
ko05321	Inflammatory bowel disease (IBD)	2/1080	56/7206	0.0130068321913
ko05140	Leishmaniasis	4/1080	75/7206	0.0141806698848
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1080	182/7206	0.015356499954
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1080	100/7206	0.0157856505463
ko04120	Ubiquitin mediated proteolysis	11/1080	138/7206	0.0160188720915
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1080	15/7206	0.0166382131698
ko04210	Apoptosis	16/1080	180/7206	0.0195161173282
ko04622	RIG-I-like receptor signaling pathway	3/1080	62/7206	0.019594556594
ko04214	Apoptosis - fly	4/1080	72/7206	0.0197097487759
ko05231	Choline metabolism in cancer	30/1080	134/7206	0.0198706978769
ko04115	p53 signaling pathway	4/1080	74/7206	0.020296494832
ko04213	Longevity regulating pathway - multiple species	21/1080	86/7206	0.021261087005
ko05202	Transcriptional misregulation in cancer	17/1080	188/7206	0.0221011695386
ko01200	Carbon metabolism	10/1080	128/7206	0.0235160849854
ko04973	Carbohydrate digestion and absorption	12/1080	42/7206	0.0264277415554
ko04630	Jak-STAT signaling pathway	11/1080	132/7206	0.0268829662106
ko03320	PPAR signaling pathway	4/1080	69/7206	0.0272850200618
ko04012	ErbB signaling pathway	25/1080	109/7206	0.029184766009
ko05161	Hepatitis B	16/1080	173/7206	0.0308343582939
ko00512	Mucin type O-glycan biosynthesis	9/1080	29/7206	0.030921448977
ko04722	Neurotrophin signaling pathway	34/1080	160/7206	0.0325236566856
ko04071	Sphingolipid signaling pathway	34/1080	162/7206	0.0344027025975
ko00982	Drug metabolism - cytochrome P450	1/1080	37/7206	0.0348677666789
ko00630	Glyoxylate and dicarboxylate metabolism	1/1080	38/7206	0.0361626816642
ko05214	Glioma	19/1080	79/7206	0.0372963132247
ko00620	Pyruvate metabolism	2/1080	46/7206	0.0381494190077
ko05204	Chemical carcinogenesis	2/1080	48/7206	0.0393333281264
ko04320	Dorso-ventral axis formation	9/1080	31/7206	0.0400430932863
ko04626	Plant-pathogen interaction	6/1080	18/7206	0.0415419462758
ko04217	Necroptosis	17/1080	178/7206	0.042661174116
ko00190	Oxidative phosphorylation	11/1080	127/7206	0.0443042036579
ko04966	Collecting duct acid secretion	8/1080	26/7206	0.0462336852402