ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	175/1004	423/7206	4.28293079803e-47
ko04724	Glutamatergic synapse	81/1004	152/7206	4.04763563746e-31
ko05033	Nicotine addiction	46/1004	56/7206	1.4978764367e-30
ko05032	Morphine addiction	62/1004	110/7206	8.20498743555e-26
ko04713	Circadian entrainment	69/1004	136/7206	5.91189497391e-25
ko04727	GABAergic synapse	60/1004	110/7206	5.44335012129e-24
ko04728	Dopaminergic synapse	81/1004	185/7206	1.09243360866e-23
ko04723	Retrograde endocannabinoid signaling	72/1004	175/7206	2.8464331988e-19
ko04725	Cholinergic synapse	68/1004	160/7206	3.56421068005e-19
ko04721	Synaptic vesicle cycle	43/1004	80/7206	3.35927414463e-17
ko04020	Calcium signaling pathway	88/1004	265/7206	4.22086415989e-16
ko04911	Insulin secretion	52/1004	117/7206	6.34618271384e-16
ko04726	Serotonergic synapse	56/1004	137/7206	4.3487205125e-15
ko04024	cAMP signaling pathway	87/1004	279/7206	3.67124869049e-14
ko04921	Oxytocin signaling pathway	70/1004	209/7206	2.63956582185e-13
ko05031	Amphetamine addiction	41/1004	91/7206	4.58991703469e-13
ko04742	Taste transduction	31/1004	61/7206	6.64801858833e-12
ko04720	Long-term potentiation	41/1004	99/7206	1.32806470446e-11
ko04261	Adrenergic signaling in cardiomyocytes	65/1004	205/7206	4.60419339844e-11
ko04744	Phototransduction	22/1004	36/7206	6.46460045508e-11
ko04970	Salivary secretion	37/1004	95/7206	1.08205448537e-09
ko04925	Aldosterone synthesis and secretion	38/1004	105/7206	7.29658976352e-09
ko03040	Spliceosome	1/1004	145/7206	1.48060054761e-08
ko04971	Gastric acid secretion	35/1004	98/7206	4.2362822897e-08
ko04360	Axon guidance	63/1004	233/7206	7.70694602449e-08
ko05203	Viral carcinogenesis	12/1004	277/7206	1.86837008732e-07
ko04070	Phosphatidylinositol signaling system	37/1004	112/7206	2.22753347635e-07
ko05030	Cocaine addiction	27/1004	73/7206	6.69531977678e-07
ko04010	MAPK signaling pathway	76/1004	321/7206	1.42263662319e-06
ko04740	Olfactory transduction	28/1004	80/7206	1.52632828101e-06
ko04514	Cell adhesion molecules (CAMs)	39/1004	130/7206	2.08926967075e-06
ko04730	Long-term depression	27/1004	78/7206	2.99069412155e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1004	74/7206	3.31323450854e-06
ko04745	Phototransduction - fly	17/1004	38/7206	3.9387626098e-06
ko05322	Systemic lupus erythematosus	4/1004	151/7206	3.98002144192e-06
ko04621	NOD-like receptor signaling pathway	5/1004	157/7206	1.09028165675e-05
ko04972	Pancreatic secretion	33/1004	111/7206	1.20192143359e-05
ko04022	cGMP-PKG signaling pathway	54/1004	216/7206	1.34842581268e-05
ko04072	Phospholipase D signaling pathway	50/1004	197/7206	1.44338961188e-05
ko04750	Inflammatory mediator regulation of TRP channels	35/1004	122/7206	1.64374418682e-05
ko05168	Herpes simplex infection	8/1004	182/7206	3.12479704725e-05
ko04060	Cytokine-cytokine receptor interaction	9/1004	191/7206	4.61924932264e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1004	79/7206	4.68098032895e-05
ko03013	RNA transport	7/1004	166/7206	5.73310832508e-05
ko05164	Influenza A	7/1004	167/7206	5.85166268195e-05
ko04120	Ubiquitin mediated proteolysis	5/1004	138/7206	9.25194022708e-05
ko04014	Ras signaling pathway	62/1004	279/7206	0.000132199356619
ko04540	Gap junction	34/1004	128/7206	0.000142535035296
ko04110	Cell cycle	6/1004	145/7206	0.00014640230056
ko04612	Antigen processing and presentation	1/1004	77/7206	0.000197367654149
ko05169	Epstein-Barr virus infection	12/1004	206/7206	0.000306832382713
ko04141	Protein processing in endoplasmic reticulum	10/1004	184/7206	0.00032105425083
ko04260	Cardiac muscle contraction	27/1004	98/7206	0.000333214852466
ko04966	Collecting duct acid secretion	11/1004	26/7206	0.000377697980426
ko05414	Dilated cardiomyopathy	28/1004	112/7206	0.00143628806747
ko03008	Ribosome biogenesis in eukaryotes	2/1004	79/7206	0.001494125186
ko05110	Vibrio cholerae infection	18/1004	63/7206	0.00263786082121
ko04960	Aldosterone-regulated sodium reabsorption	13/1004	41/7206	0.0027727606957
ko04915	Estrogen signaling pathway	31/1004	131/7206	0.00303871076496
ko05231	Choline metabolism in cancer	31/1004	134/7206	0.00350391844533
ko04924	Renin secretion	22/1004	86/7206	0.00411116933736
ko04610	Complement and coagulation cascades	3/1004	79/7206	0.00504656874071
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1004	100/7206	0.00556642382625
ko04015	Rap1 signaling pathway	55/1004	278/7206	0.00598472691934
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/1004	59/7206	0.00700786192898
ko04630	Jak-STAT signaling pathway	8/1004	132/7206	0.0071459064473
ko05162	Measles	7/1004	120/7206	0.00735578765831
ko04626	Plant-pathogen interaction	7/1004	18/7206	0.00782406773606
ko04146	Peroxisome	4/1004	89/7206	0.00789205194626
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1004	14/7206	0.00796885763983
ko04930	Type II diabetes mellitus	15/1004	54/7206	0.00848218018275
ko05016	Huntington's disease	17/1004	215/7206	0.00895051591252
ko05166	HTLV-I infection	26/1004	292/7206	0.00953199351229
ko05161	Hepatitis B	13/1004	173/7206	0.0105062894599
ko04064	NF-kappa B signaling pathway	5/1004	96/7206	0.010763559082
ko00260	Glycine, serine and threonine metabolism	1/1004	48/7206	0.0109767407409
ko05219	Bladder cancer	1/1004	48/7206	0.0109767407409
ko04973	Carbohydrate digestion and absorption	12/1004	42/7206	0.0117699166766
ko04912	GnRH signaling pathway	27/1004	122/7206	0.0118639917312
ko05214	Glioma	19/1004	79/7206	0.0135879726312
ko04710	Circadian rhythm	12/1004	43/7206	0.0136717011363
ko04964	Proximal tubule bicarbonate reclamation	9/1004	29/7206	0.0140329071407
ko04214	Apoptosis - fly	3/1004	72/7206	0.0150103496697
ko04217	Necroptosis	14/1004	178/7206	0.0156122999739
ko00071	Fatty acid degradation	1/1004	45/7206	0.0162709860271
ko03420	Nucleotide excision repair	1/1004	46/7206	0.0165843288177
ko04918	Thyroid hormone synthesis	20/1004	86/7206	0.017786986255
ko00240	Pyrimidine metabolism	7/1004	110/7206	0.0178003871077
ko05205	Proteoglycans in cancer	25/1004	271/7206	0.0200717258774
ko04976	Bile secretion	19/1004	80/7206	0.0212848559794
ko04071	Sphingolipid signaling pathway	33/1004	162/7206	0.0213088315976
ko04711	Circadian rhythm - fly	5/1004	13/7206	0.025424950686
ko03022	Basal transcription factors	1/1004	44/7206	0.0254819008219
ko04658	Th1 and Th2 cell differentiation	6/1004	96/7206	0.0255012818517
ko04922	Glucagon signaling pathway	27/1004	128/7206	0.0273929479544
ko05140	Leishmaniasis	4/1004	75/7206	0.0282526408078
ko04640	Hematopoietic cell lineage	3/1004	64/7206	0.0285456508924
ko04210	Apoptosis	15/1004	180/7206	0.0286004228892
ko00562	Inositol phosphate metabolism	20/1004	89/7206	0.0293304342422
ko04350	TGF-beta signaling pathway	7/1004	103/7206	0.0315044498448
ko05202	Transcriptional misregulation in cancer	16/1004	188/7206	0.0320407427285
ko04270	Vascular smooth muscle contraction	31/1004	154/7206	0.0332722402208
ko04012	ErbB signaling pathway	23/1004	109/7206	0.0359302385732
ko03018	RNA degradation	5/1004	84/7206	0.0374612965733
ko05215	Prostate cancer	8/1004	111/7206	0.0378071144258
ko00310	Lysine degradation	4/1004	73/7206	0.0394105431483
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1004	182/7206	0.0396527880023
ko00330	Arginine and proline metabolism	3/1004	61/7206	0.0399235266073
ko04330	Notch signaling pathway	3/1004	62/7206	0.040466808273
ko04622	RIG-I-like receptor signaling pathway	3/1004	62/7206	0.040466808273
ko00590	Arachidonic acid metabolism	2/1004	52/7206	0.0410115627302
ko05222	Small cell lung cancer	6/1004	89/7206	0.0455907994821
ko04923	Regulation of lipolysis in adipocytes	17/1004	77/7206	0.0461108325269
ko04371	Apelin signaling pathway	34/1004	177/7206	0.0472834224692
ko04722	Neurotrophin signaling pathway	31/1004	160/7206	0.0494890137085
ko04916	Melanogenesis	28/1004	142/7206	0.0499149391682