ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 31/189 152/7206 1.0772110313e-19 ko05033 Nicotine addiction 17/189 56/7206 2.5639007152e-14 ko04728 Dopaminergic synapse 26/189 185/7206 1.33733413976e-12 ko04727 GABAergic synapse 20/189 110/7206 4.88360877256e-12 ko04080 Neuroactive ligand-receptor interaction 37/189 423/7206 4.43083884943e-11 ko05032 Morphine addiction 17/189 110/7206 2.92674422182e-09 ko04723 Retrograde endocannabinoid signaling 21/189 175/7206 4.35898605953e-09 ko04713 Circadian entrainment 18/189 136/7206 1.25315090195e-08 ko04721 Synaptic vesicle cycle 14/189 80/7206 1.4911623449e-08 ko05030 Cocaine addiction 13/189 73/7206 4.00226394291e-08 ko05031 Amphetamine addiction 14/189 91/7206 8.20113101762e-08 ko04911 Insulin secretion 15/189 117/7206 3.32262359269e-07 ko04024 cAMP signaling pathway 23/189 279/7206 9.00584945434e-07 ko05014 Amyotrophic lateral sclerosis (ALS) 11/189 74/7206 2.98831182056e-06 ko04725 Cholinergic synapse 16/189 160/7206 3.94327171729e-06 ko04726 Serotonergic synapse 14/189 137/7206 1.26219740093e-05 ko04730 Long-term depression 10/189 78/7206 3.24639689058e-05 ko04514 Cell adhesion molecules (CAMs) 12/189 130/7206 0.00014415291259 ko04720 Long-term potentiation 10/189 99/7206 0.000249546043368 ko04261 Adrenergic signaling in cardiomyocytes 15/189 205/7206 0.000298547948126 ko04972 Pancreatic secretion 10/189 111/7206 0.000629135598181 ko04742 Taste transduction 7/189 61/7206 0.00100623947745 ko04010 MAPK signaling pathway 18/189 321/7206 0.00199195836541 ko04970 Salivary secretion 8/189 95/7206 0.00334689331691 ko04260 Cardiac muscle contraction 8/189 98/7206 0.0040543619022 ko04960 Aldosterone-regulated sodium reabsorption 5/189 41/7206 0.00409910409099 ko04020 Calcium signaling pathway 15/189 265/7206 0.00476218688691 ko04360 Axon guidance 14/189 233/7206 0.00499916096675 ko04964 Proximal tubule bicarbonate reclamation 4/189 29/7206 0.00651579966497 ko05034 Alcoholism 13/189 238/7206 0.0112095060025 ko04921 Oxytocin signaling pathway 12/189 209/7206 0.0122643024538 ko04930 Type II diabetes mellitus 5/189 54/7206 0.0131652753862 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 6/189 79/7206 0.017159406947 ko04961 Endocrine and other factor-regulated calcium reabsorption 5/189 59/7206 0.0187755777686 ko04973 Carbohydrate digestion and absorption 4/189 42/7206 0.0236071116764 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/189 1/7206 0.0262281432141 ko05166 HTLV-I infection 2/189 292/7206 0.0364245475797 ko04971 Gastric acid secretion 6/189 98/7206 0.0434211470433 ko05010 Alzheimer's disease 10/189 202/7206 0.043759889602 ko04810 Regulation of actin cytoskeleton 2/189 264/7206 0.0489973432531