ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 110/749 423/7206 4.67450159558e-21 ko04724 Glutamatergic synapse 57/749 152/7206 2.84775617021e-19 ko05032 Morphine addiction 42/749 110/7206 8.05784589881e-15 ko04721 Synaptic vesicle cycle 35/749 80/7206 1.10639408826e-14 ko04713 Circadian entrainment 47/749 136/7206 1.69950885472e-14 ko04728 Dopaminergic synapse 56/749 185/7206 3.46973199821e-14 ko04727 GABAergic synapse 41/749 110/7206 4.46360339027e-14 ko05033 Nicotine addiction 28/749 56/7206 8.20495224963e-14 ko04911 Insulin secretion 40/749 117/7206 2.40082029792e-12 ko04024 cAMP signaling pathway 68/749 279/7206 7.11119354171e-12 ko04723 Retrograde endocannabinoid signaling 49/749 175/7206 3.49590819241e-11 ko04725 Cholinergic synapse 46/749 160/7206 5.29842479007e-11 ko04726 Serotonergic synapse 40/749 137/7206 5.94822366275e-10 ko04921 Oxytocin signaling pathway 52/749 209/7206 1.05676944784e-09 ko04261 Adrenergic signaling in cardiomyocytes 49/749 205/7206 1.56893506801e-08 ko05031 Amphetamine addiction 28/749 91/7206 6.77413272254e-08 ko04720 Long-term potentiation 29/749 99/7206 1.31144502055e-07 ko04744 Phototransduction 16/749 36/7206 1.56936366402e-07 ko04020 Calcium signaling pathway 56/749 265/7206 1.58959158896e-07 ko04966 Collecting duct acid secretion 13/749 26/7206 4.28962822085e-07 ko04970 Salivary secretion 27/749 95/7206 6.94671393021e-07 ko04925 Aldosterone synthesis and secretion 28/749 105/7206 1.78029228701e-06 ko04745 Phototransduction - fly 15/749 38/7206 2.42883867603e-06 ko05110 Vibrio cholerae infection 20/749 63/7206 2.98330989015e-06 ko05168 Herpes simplex infection 3/749 182/7206 5.95103379685e-06 ko05030 Cocaine addiction 21/749 73/7206 9.73689743369e-06 ko04070 Phosphatidylinositol signaling system 28/749 112/7206 1.11372478863e-05 ko03010 Ribosome 1/749 129/7206 1.56227247854e-05 ko05322 Systemic lupus erythematosus 2/749 151/7206 1.85160587946e-05 ko03040 Spliceosome 2/749 145/7206 2.67462122337e-05 ko04730 Long-term depression 21/749 78/7206 2.96551596655e-05 ko03013 RNA transport 4/749 166/7206 0.00014699591262 ko04971 Gastric acid secretion 23/749 98/7206 0.000150122267528 ko04626 Plant-pathogen interaction 8/749 18/7206 0.000221982791249 ko04022 cGMP-PKG signaling pathway 40/749 216/7206 0.000246861235319 ko04742 Taste transduction 16/749 61/7206 0.000359323791531 ko04972 Pancreatic secretion 24/749 111/7206 0.000421783617302 ko05014 Amyotrophic lateral sclerosis (ALS) 18/749 74/7206 0.000716800172363 ko04750 Inflammatory mediator regulation of TRP channels 25/749 122/7206 0.000797690126019 ko04014 Ras signaling pathway 47/749 279/7206 0.000864476289438 ko04010 MAPK signaling pathway 52/749 321/7206 0.000990471326274 ko04072 Phospholipase D signaling pathway 35/749 197/7206 0.00128786341691 ko04514 Cell adhesion molecules (CAMs) 25/749 130/7206 0.00206014655452 ko05162 Measles 3/749 120/7206 0.0021400331262 ko04630 Jak-STAT signaling pathway 4/749 132/7206 0.0023159321665 ko04960 Aldosterone-regulated sodium reabsorption 11/749 41/7206 0.00241478248621 ko05120 Epithelial cell signaling in Helicobacter pylori infection 19/749 92/7206 0.00295488805712 ko04360 Axon guidance 39/749 233/7206 0.00295520277755 ko04621 NOD-like receptor signaling pathway 6/749 157/7206 0.00345407895094 ko04110 Cell cycle 5/749 145/7206 0.00346552223382 ko04260 Cardiac muscle contraction 20/749 98/7206 0.00380822333373 ko04612 Antigen processing and presentation 1/749 77/7206 0.00401058156842 ko05203 Viral carcinogenesis 15/749 277/7206 0.00465766879191 ko04540 Gap junction 24/749 128/7206 0.00480845496891 ko00680 Methane metabolism 9/749 34/7206 0.00648012921104 ko04120 Ubiquitin mediated proteolysis 5/749 138/7206 0.00670910846227 ko04060 Cytokine-cytokine receptor interaction 9/749 191/7206 0.00766072078287 ko04961 Endocrine and other factor-regulated calcium reabsorption 13/749 59/7206 0.0080326266203 ko04510 Focal adhesion 13/749 240/7206 0.00934500269825 ko04141 Protein processing in endoplasmic reticulum 9/749 184/7206 0.00989143922245 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/749 14/7206 0.0107709913397 ko04924 Renin secretion 17/749 86/7206 0.0111710274443 ko00562 Inositol phosphate metabolism 17/749 89/7206 0.0128144299702 ko05010 Alzheimer's disease 32/749 202/7206 0.0137297061408 ko05166 HTLV-I infection 18/749 292/7206 0.0140456918535 ko05164 Influenza A 8/749 167/7206 0.0140988432562 ko05169 Epstein-Barr virus infection 11/749 206/7206 0.014388588137 ko04064 NF-kappa B signaling pathway 3/749 96/7206 0.016771887535 ko04810 Regulation of actin cytoskeleton 16/749 264/7206 0.0176401025317 ko04922 Glucagon signaling pathway 22/749 128/7206 0.0180892432026 ko04330 Notch signaling pathway 1/749 62/7206 0.0189140978518 ko04915 Estrogen signaling pathway 22/749 131/7206 0.020386118838 ko05140 Leishmaniasis 2/749 75/7206 0.0214598296315 ko04146 Peroxisome 3/749 89/7206 0.0226967997676 ko04114 Oocyte meiosis 23/749 139/7206 0.0235917904845 ko04930 Type II diabetes mellitus 11/749 54/7206 0.0236953491973 ko04740 Olfactory transduction 15/749 80/7206 0.0244285858399 ko05205 Proteoglycans in cancer 17/749 271/7206 0.0249214369894 ko04145 Phagosome 26/749 162/7206 0.0256448538017 ko04964 Proximal tubule bicarbonate reclamation 7/749 29/7206 0.0258969142375 ko05034 Alcoholism 35/749 238/7206 0.0306681808409 ko04520 Adherens junction 4/749 103/7206 0.0323242924982 ko05323 Rheumatoid arthritis 16/749 89/7206 0.0332995328295 ko04152 AMPK signaling pathway 25/749 161/7206 0.0363195971318 ko00280 Valine, leucine and isoleucine degradation 1/749 54/7206 0.0401595228653 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 14/749 79/7206 0.0402010706257 ko05161 Hepatitis B 10/749 173/7206 0.0431986727741 ko04371 Apelin signaling pathway 27/749 177/7206 0.0446055906004 ko04918 Thyroid hormone synthesis 15/749 86/7206 0.0474042435951 ko04016 MAPK signaling pathway - plant 5/749 20/7206 0.0495106453619