ko pathway ratio_in_study ratio_in_pop p_value ko04070 Phosphatidylinositol signaling system 27/466 112/7206 1.37175627933e-09 ko04725 Cholinergic synapse 26/466 160/7206 1.02652947087e-05 ko04710 Circadian rhythm 12/466 43/7206 1.12559637463e-05 ko04360 Axon guidance 33/466 233/7206 1.65486362937e-05 ko04960 Aldosterone-regulated sodium reabsorption 10/466 41/7206 0.000210643905052 ko05032 Morphine addiction 18/466 110/7206 0.000216146349569 ko04024 cAMP signaling pathway 34/466 279/7206 0.000275703787966 ko04014 Ras signaling pathway 34/466 279/7206 0.000275703787966 ko04724 Glutamatergic synapse 22/466 152/7206 0.00031709683461 ko04964 Proximal tubule bicarbonate reclamation 8/466 29/7206 0.000368437164127 ko00562 Inositol phosphate metabolism 15/466 89/7206 0.000517634584401 ko04721 Synaptic vesicle cycle 14/466 80/7206 0.000533219809148 ko04072 Phospholipase D signaling pathway 26/466 197/7206 0.000545993417496 ko05230 Central carbon metabolism in cancer 14/466 81/7206 0.000607402630135 ko05322 Systemic lupus erythematosus 1/466 151/7206 0.000688564104787 ko04071 Sphingolipid signaling pathway 22/466 162/7206 0.000912183914689 ko04711 Circadian rhythm - fly 5/466 13/7206 0.00092226879774 ko04650 Natural killer cell mediated cytotoxicity 15/466 97/7206 0.00130260392505 ko04921 Oxytocin signaling pathway 26/466 209/7206 0.00137701967697 ko04911 Insulin secretion 17/466 117/7206 0.0016765053589 ko03013 RNA transport 2/466 166/7206 0.00204749726049 ko04713 Circadian entrainment 18/466 136/7206 0.00386348136716 ko04966 Collecting duct acid secretion 6/466 26/7206 0.00536542651318 ko04261 Adrenergic signaling in cardiomyocytes 24/466 205/7206 0.0054643297094 ko04919 Thyroid hormone signaling pathway 18/466 143/7206 0.0054897861689 ko04728 Dopaminergic synapse 22/466 185/7206 0.00559410281491 ko04015 Rap1 signaling pathway 30/466 278/7206 0.00569508093772 ko04010 MAPK signaling pathway 33/466 321/7206 0.0072282225272 ko04666 Fc gamma R-mediated phagocytosis 16/466 122/7206 0.00766516584989 ko05120 Epithelial cell signaling in Helicobacter pylori infection 13/466 92/7206 0.0079889848052 ko04722 Neurotrophin signaling pathway 19/466 160/7206 0.0086833483378 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/466 14/7206 0.0102682477333 ko05210 Colorectal cancer 12/466 86/7206 0.0119757329494 ko04144 Endocytosis 34/466 342/7206 0.0125372997135 ko04068 FoxO signaling pathway 19/466 167/7206 0.0155249757176 ko04664 Fc epsilon RI signaling pathway 11/466 77/7206 0.0157702947551 ko04022 cGMP-PKG signaling pathway 23/466 216/7206 0.0162536606253 ko04730 Long-term depression 11/466 78/7206 0.0163999484987 ko04973 Carbohydrate digestion and absorption 7/466 42/7206 0.0169492827596 ko05231 Choline metabolism in cancer 16/466 134/7206 0.0188221419204 ko05110 Vibrio cholerae infection 9/466 63/7206 0.0191183323197 ko04931 Insulin resistance 16/466 137/7206 0.0205579450723 ko04020 Calcium signaling pathway 27/466 265/7206 0.0208475533886 ko04930 Type II diabetes mellitus 8/466 54/7206 0.0216421015978 ko04152 AMPK signaling pathway 18/466 161/7206 0.0216592405856 ko00471 D-Glutamine and D-glutamate metabolism 2/466 4/7206 0.0229428991463 ko04371 Apelin signaling pathway 19/466 177/7206 0.0285400127471 ko04727 GABAergic synapse 13/466 110/7206 0.0299129548162 ko04972 Pancreatic secretion 13/466 111/7206 0.0312996909075 ko05214 Glioma 10/466 79/7206 0.0350984546044 ko04066 HIF-1 signaling pathway 14/466 123/7206 0.0386785528649 ko05418 Fluid shear stress and atherosclerosis 18/466 173/7206 0.0408166342541 ko04925 Aldosterone synthesis and secretion 12/466 105/7206 0.0448886495978