ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	178/1049	423/7206	2.67966619112e-46
ko04724	Glutamatergic synapse	81/1049	152/7206	9.79222490445e-30
ko05033	Nicotine addiction	44/1049	56/7206	6.50263067484e-27
ko05032	Morphine addiction	58/1049	110/7206	2.93532024415e-21
ko04728	Dopaminergic synapse	79/1049	185/7206	4.77943641202e-21
ko04721	Synaptic vesicle cycle	47/1049	80/7206	4.61814638538e-20
ko04713	Circadian entrainment	64/1049	136/7206	6.30525414013e-20
ko04727	GABAergic synapse	56/1049	110/7206	1.29926187402e-19
ko04725	Cholinergic synapse	69/1049	160/7206	8.60432701096e-19
ko04723	Retrograde endocannabinoid signaling	68/1049	175/7206	1.07116744701e-15
ko04024	cAMP signaling pathway	90/1049	279/7206	2.61378427752e-14
ko04726	Serotonergic synapse	55/1049	137/7206	1.28190709485e-13
ko04742	Taste transduction	33/1049	61/7206	4.75688823996e-13
ko04020	Calcium signaling pathway	84/1049	265/7206	4.76590400606e-13
ko04921	Oxytocin signaling pathway	68/1049	209/7206	2.29231422784e-11
ko04911	Insulin secretion	46/1049	117/7206	3.17908558846e-11
ko04261	Adrenergic signaling in cardiomyocytes	65/1049	205/7206	2.5286588571e-10
ko04360	Axon guidance	71/1049	233/7206	2.85112532121e-10
ko05031	Amphetamine addiction	37/1049	91/7206	9.03477228663e-10
ko04744	Phototransduction	21/1049	36/7206	1.38194943848e-09
ko05203	Viral carcinogenesis	10/1049	277/7206	1.84210922012e-09
ko04720	Long-term potentiation	38/1049	99/7206	3.74215315428e-09
ko03040	Spliceosome	1/1049	145/7206	5.96445728766e-09
ko04970	Salivary secretion	36/1049	95/7206	1.43868942339e-08
ko04060	Cytokine-cytokine receptor interaction	6/1049	191/7206	2.08998781288e-07
ko05164	Influenza A	5/1049	167/7206	1.07913177746e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1049	74/7206	2.19703928247e-06
ko04621	NOD-like receptor signaling pathway	5/1049	157/7206	3.26887180118e-06
ko05168	Herpes simplex infection	7/1049	182/7206	3.28801915816e-06
ko04740	Olfactory transduction	28/1049	80/7206	3.69580709523e-06
ko05030	Cocaine addiction	26/1049	73/7206	5.66802957369e-06
ko03013	RNA transport	6/1049	166/7206	5.80257451241e-06
ko05322	Systemic lupus erythematosus	5/1049	151/7206	6.87997306762e-06
ko04120	Ubiquitin mediated proteolysis	4/1049	138/7206	7.82788032324e-06
ko04971	Gastric acid secretion	31/1049	98/7206	1.56406010246e-05
ko04010	MAPK signaling pathway	75/1049	321/7206	1.57271572618e-05
ko04022	cGMP-PKG signaling pathway	55/1049	216/7206	1.98626741324e-05
ko04745	Phototransduction - fly	16/1049	38/7206	3.41302662167e-05
ko04141	Protein processing in endoplasmic reticulum	9/1049	184/7206	4.48949342956e-05
ko04925	Aldosterone synthesis and secretion	31/1049	105/7206	6.69255847288e-05
ko04730	Long-term depression	25/1049	78/7206	7.08961838105e-05
ko04924	Renin secretion	27/1049	86/7206	7.10978843621e-05
ko04514	Cell adhesion molecules (CAMs)	36/1049	130/7206	7.93061481539e-05
ko04966	Collecting duct acid secretion	12/1049	26/7206	0.000113624736175
ko04014	Ras signaling pathway	64/1049	279/7206	0.000127488387112
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1049	79/7206	0.000138549427564
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1049	14/7206	0.00026027096448
ko05169	Epstein-Barr virus infection	13/1049	206/7206	0.000276586668764
ko04540	Gap junction	34/1049	128/7206	0.000329852643964
ko04064	NF-kappa B signaling pathway	3/1049	96/7206	0.000380650142855
ko04260	Cardiac muscle contraction	28/1049	98/7206	0.000405234212184
ko04972	Pancreatic secretion	30/1049	111/7206	0.0005651843511
ko03008	Ribosome biogenesis in eukaryotes	2/1049	79/7206	0.000629853468637
ko04612	Antigen processing and presentation	2/1049	77/7206	0.000930603747007
ko05161	Hepatitis B	11/1049	173/7206	0.000989802319585
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1049	59/7206	0.00139101553227
ko05140	Leishmaniasis	2/1049	75/7206	0.00139756134611
ko00330	Arginine and proline metabolism	1/1049	61/7206	0.00147502840479
ko05205	Proteoglycans in cancer	22/1049	271/7206	0.00149250563978
ko04070	Phosphatidylinositol signaling system	29/1049	112/7206	0.00162044573429
ko03018	RNA degradation	3/1049	84/7206	0.00166237636629
ko04750	Inflammatory mediator regulation of TRP channels	30/1049	122/7206	0.00275528606369
ko05414	Dilated cardiomyopathy	28/1049	112/7206	0.00284953853891
ko00480	Glutathione metabolism	1/1049	55/7206	0.00326115068168
ko05110	Vibrio cholerae infection	18/1049	63/7206	0.00349986456029
ko04146	Peroxisome	4/1049	89/7206	0.00374191984293
ko04668	TNF signaling pathway	7/1049	120/7206	0.00385930869478
ko05162	Measles	7/1049	120/7206	0.00385930869478
ko00590	Arachidonic acid metabolism	1/1049	52/7206	0.00484934434312
ko01524	Platinum drug resistance	3/1049	76/7206	0.0049130567441
ko01200	Carbon metabolism	8/1049	128/7206	0.00505865985335
ko04072	Phospholipase D signaling pathway	43/1049	197/7206	0.00541133429878
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/1049	182/7206	0.00554528201916
ko04110	Cell cycle	10/1049	145/7206	0.00595999434651
ko04640	Hematopoietic cell lineage	2/1049	64/7206	0.00644190582436
ko04371	Apelin signaling pathway	39/1049	177/7206	0.00667370426841
ko00310	Lysine degradation	3/1049	73/7206	0.00700090497829
ko04626	Plant-pathogen interaction	7/1049	18/7206	0.00995682880418
ko04214	Apoptosis - fly	3/1049	72/7206	0.0104335554386
ko00620	Pyruvate metabolism	1/1049	46/7206	0.0107102170536
ko03420	Nucleotide excision repair	1/1049	46/7206	0.0107102170536
ko05418	Fluid shear stress and atherosclerosis	14/1049	173/7206	0.0119293870968
ko00240	Pyrimidine metabolism	7/1049	110/7206	0.0132891165326
ko05145	Toxoplasmosis	9/1049	126/7206	0.0149448193217
ko03022	Basal transcription factors	1/1049	44/7206	0.0161916176906
ko05144	Malaria	1/1049	45/7206	0.0169056050472
ko00071	Fatty acid degradation	1/1049	45/7206	0.0169056050472
ko04915	Estrogen signaling pathway	29/1049	131/7206	0.0171548423124
ko04217	Necroptosis	15/1049	178/7206	0.0174857894788
ko00280	Valine, leucine and isoleucine degradation	2/1049	54/7206	0.0187923106242
ko04115	p53 signaling pathway	4/1049	74/7206	0.0200021458184
ko05166	HTLV-I infection	29/1049	292/7206	0.0218862520633
ko04722	Neurotrophin signaling pathway	34/1049	160/7206	0.0225644170827
ko04391	Hippo signaling pathway - fly	21/1049	90/7206	0.0233496531552
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1049	40/7206	0.023568721666
ko00140	Steroid hormone biosynthesis	1/1049	41/7206	0.0239002109523
ko04140	Autophagy - animal	14/1049	164/7206	0.024843561036
ko04976	Bile secretion	19/1049	80/7206	0.0249860075393
ko05131	Shigellosis	5/1049	82/7206	0.0265939541062
ko00380	Tryptophan metabolism	2/1049	50/7206	0.0269865530885
ko04622	RIG-I-like receptor signaling pathway	3/1049	62/7206	0.0282565889484
ko04964	Proximal tubule bicarbonate reclamation	9/1049	29/7206	0.0287575219963
ko00561	Glycerolipid metabolism	3/1049	63/7206	0.0289783444585
ko04916	Melanogenesis	30/1049	142/7206	0.0301422532107
ko04620	Toll-like receptor signaling pathway	7/1049	100/7206	0.0311307045252
ko05222	Small cell lung cancer	6/1049	89/7206	0.0335877018934
ko00982	Drug metabolism - cytochrome P450	1/1049	37/7206	0.0348833441134
ko03410	Base excision repair	1/1049	38/7206	0.0352396767987
ko05219	Bladder cancer	2/1049	48/7206	0.0386733436074
ko05206	MicroRNAs in cancer	16/1049	177/7206	0.0394708083319
ko04658	Th1 and Th2 cell differentiation	7/1049	96/7206	0.0409542970701
ko05410	Hypertrophic cardiomyopathy (HCM)	22/1049	100/7206	0.0441430247141
ko04630	Jak-STAT signaling pathway	11/1049	132/7206	0.0451637019109
ko04657	IL-17 signaling pathway	6/1049	87/7206	0.0452531458332
ko05133	Pertussis	6/1049	87/7206	0.0452531458332
ko04350	TGF-beta signaling pathway	8/1049	103/7206	0.048585982867