ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	127/747	423/7206	3.02130208104e-31
ko04724	Glutamatergic synapse	71/747	152/7206	5.30502217758e-31
ko05033	Nicotine addiction	41/747	56/7206	5.70621469515e-29
ko04727	GABAergic synapse	51/747	110/7206	2.55302253171e-22
ko05032	Morphine addiction	51/747	110/7206	2.55302253171e-22
ko04728	Dopaminergic synapse	65/747	185/7206	3.85004622204e-20
ko04723	Retrograde endocannabinoid signaling	62/747	175/7206	1.82642075905e-19
ko04713	Circadian entrainment	53/747	136/7206	6.38194297838e-19
ko04024	cAMP signaling pathway	78/747	279/7206	3.29795707581e-17
ko04725	Cholinergic synapse	54/747	160/7206	5.03215251408e-16
ko04721	Synaptic vesicle cycle	35/747	80/7206	1.01899664446e-14
ko04911	Insulin secretion	43/747	117/7206	1.71706342573e-14
ko04921	Oxytocin signaling pathway	57/747	209/7206	2.40489810868e-12
ko04020	Calcium signaling pathway	64/747	265/7206	4.14042950895e-11
ko04742	Taste transduction	26/747	61/7206	5.96067152936e-11
ko04261	Adrenergic signaling in cardiomyocytes	53/747	205/7206	1.32497492052e-10
ko05031	Amphetamine addiction	32/747	91/7206	1.5851735783e-10
ko04720	Long-term potentiation	33/747	99/7206	4.13380667495e-10
ko04726	Serotonergic synapse	39/747	137/7206	2.03861141251e-09
ko05030	Cocaine addiction	25/747	73/7206	3.02772398049e-08
ko04010	MAPK signaling pathway	64/747	321/7206	1.63166087827e-07
ko04514	Cell adhesion molecules (CAMs)	33/747	130/7206	6.92590181975e-07
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	24/747	79/7206	7.27265227669e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	23/747	74/7206	7.89620132348e-07
ko04744	Phototransduction	15/747	36/7206	1.03105986319e-06
ko04970	Salivary secretion	26/747	95/7206	2.32886443963e-06
ko04060	Cytokine-cytokine receptor interaction	3/747	191/7206	2.83819591272e-06
ko03040	Spliceosome	1/747	145/7206	3.12415895637e-06
ko04740	Olfactory transduction	23/747	80/7206	3.56734234921e-06
ko04925	Aldosterone synthesis and secretion	27/747	105/7206	5.4811743943e-06
ko05203	Viral carcinogenesis	9/747	277/7206	1.183929694e-05
ko04972	Pancreatic secretion	27/747	111/7206	2.14344666747e-05
ko05168	Herpes simplex infection	4/747	182/7206	3.49358417096e-05
ko04260	Cardiac muscle contraction	24/747	98/7206	6.35379455365e-05
ko04971	Gastric acid secretion	24/747	98/7206	6.35379455365e-05
ko04072	Phospholipase D signaling pathway	39/747	197/7206	6.84609844848e-05
ko05164	Influenza A	4/747	167/7206	0.000149033759443
ko05414	Dilated cardiomyopathy	25/747	112/7206	0.000213684583559
ko04350	TGF-beta signaling pathway	1/747	103/7206	0.000254429765289
ko04360	Axon guidance	42/747	233/7206	0.000280008925197
ko05162	Measles	2/747	120/7206	0.000390938365914
ko04730	Long-term depression	19/747	78/7206	0.000473165204535
ko05322	Systemic lupus erythematosus	4/747	151/7206	0.000605483048449
ko03013	RNA transport	5/747	166/7206	0.000674926506493
ko04014	Ras signaling pathway	47/747	279/7206	0.000853166790712
ko04022	cGMP-PKG signaling pathway	38/747	216/7206	0.000930955075252
ko05169	Epstein-Barr virus infection	8/747	206/7206	0.00102334411602
ko04745	Phototransduction - fly	11/747	38/7206	0.0012016831379
ko04141	Protein processing in endoplasmic reticulum	7/747	184/7206	0.00136383060052
ko05410	Hypertrophic cardiomyopathy (HCM)	21/747	100/7206	0.00138248078786
ko04120	Ubiquitin mediated proteolysis	4/747	138/7206	0.00166720140393
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/747	14/7206	0.00175766172749
ko04915	Estrogen signaling pathway	25/747	131/7206	0.00216513254413
ko04630	Jak-STAT signaling pathway	4/747	132/7206	0.00232170629995
ko03008	Ribosome biogenesis in eukaryotes	1/747	79/7206	0.00267979099246
ko04070	Phosphatidylinositol signaling system	22/747	112/7206	0.00268345344768
ko04930	Type II diabetes mellitus	13/747	54/7206	0.00283997657572
ko04110	Cell cycle	5/747	145/7206	0.00344902835449
ko04612	Antigen processing and presentation	1/747	77/7206	0.00399856496391
ko00240	Pyrimidine metabolism	3/747	110/7206	0.0041683131226
ko04924	Renin secretion	17/747	86/7206	0.00723684401929
ko04540	Gap junction	23/747	128/7206	0.00781030458504
ko05166	HTLV-I infection	17/747	292/7206	0.00784229827359
ko04750	Inflammatory mediator regulation of TRP channels	22/747	122/7206	0.00984468494927
ko05161	Hepatitis B	8/747	173/7206	0.0108385797787
ko04621	NOD-like receptor signaling pathway	7/747	157/7206	0.011278942724
ko04640	Hematopoietic cell lineage	1/747	64/7206	0.0125256418352
ko04932	Non-alcoholic fatty liver disease (NAFLD)	9/747	182/7206	0.0131224495702
ko04966	Collecting duct acid secretion	7/747	26/7206	0.0141456297355
ko05231	Choline metabolism in cancer	23/747	134/7206	0.0141833909007
ko04064	NF-kappa B signaling pathway	3/747	96/7206	0.0166974281166
ko04218	Cellular senescence	9/747	177/7206	0.0170934641947
ko05215	Prostate cancer	4/747	111/7206	0.0171210165017
ko04510	Focal adhesion	14/747	240/7206	0.0173607149977
ko04330	Notch signaling pathway	1/747	62/7206	0.018849412286
ko04550	Signaling pathways regulating pluripotency of stem cells	8/747	165/7206	0.0189883527043
ko05140	Leishmaniasis	2/747	75/7206	0.0214646284466
ko04146	Peroxisome	3/747	89/7206	0.0227276835758
ko05205	Proteoglycans in cancer	17/747	271/7206	0.0248023256129
ko00512	Mucin type O-glycan biosynthesis	7/747	29/7206	0.0255583562787
ko05321	Inflammatory bowel disease (IBD)	1/747	56/7206	0.0268250680171
ko05034	Alcoholism	35/747	238/7206	0.030259516752
ko04214	Apoptosis - fly	2/747	72/7206	0.0306854100773
ko00562	Inositol phosphate metabolism	16/747	89/7206	0.0331154691706
ko04210	Apoptosis	10/747	180/7206	0.0341552267272
ko05110	Vibrio cholerae infection	12/747	63/7206	0.0346882465268
ko04973	Carbohydrate digestion and absorption	9/747	42/7206	0.035575679213
ko00280	Valine, leucine and isoleucine degradation	1/747	54/7206	0.0400557043007
ko00480	Glutathione metabolism	1/747	55/7206	0.0411551592445
ko04371	Apelin signaling pathway	27/747	177/7206	0.0443462529875
ko04961	Endocrine and other factor-regulated calcium reabsorption	11/747	59/7206	0.0498191517348