ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	201/1232	423/7206	5.12038984667e-51
ko04724	Glutamatergic synapse	90/1232	152/7206	3.42026355365e-32
ko05033	Nicotine addiction	47/1232	56/7206	6.52426542893e-28
ko05032	Morphine addiction	69/1232	110/7206	4.88816845983e-27
ko04713	Circadian entrainment	78/1232	136/7206	1.00978100667e-26
ko04727	GABAergic synapse	66/1232	110/7206	2.59440734622e-24
ko04721	Synaptic vesicle cycle	51/1232	80/7206	9.80255726102e-21
ko04728	Dopaminergic synapse	85/1232	185/7206	2.21749587959e-20
ko04725	Cholinergic synapse	76/1232	160/7206	2.16251103613e-19
ko04723	Retrograde endocannabinoid signaling	79/1232	175/7206	1.92138633088e-18
ko04020	Calcium signaling pathway	104/1232	265/7206	2.16138267082e-18
ko04024	cAMP signaling pathway	105/1232	279/7206	5.02746547605e-17
ko04742	Taste transduction	39/1232	61/7206	3.29255784097e-16
ko04911	Insulin secretion	58/1232	117/7206	3.80219236461e-16
ko04726	Serotonergic synapse	63/1232	137/7206	2.04472383397e-15
ko04921	Oxytocin signaling pathway	82/1232	209/7206	1.52039208051e-14
ko04970	Salivary secretion	48/1232	95/7206	5.50010287506e-14
ko04744	Phototransduction	25/1232	36/7206	4.69792767663e-12
ko04720	Long-term potentiation	45/1232	99/7206	3.66423338301e-11
ko04261	Adrenergic signaling in cardiomyocytes	74/1232	205/7206	4.16478619298e-11
ko03040	Spliceosome	1/1232	145/7206	7.21330818676e-11
ko05031	Amphetamine addiction	42/1232	91/7206	9.07931536666e-11
ko05203	Viral carcinogenesis	15/1232	277/7206	4.48888192615e-09
ko04022	cGMP-PKG signaling pathway	70/1232	216/7206	2.18305363061e-08
ko04971	Gastric acid secretion	39/1232	98/7206	8.01569605472e-08
ko04360	Axon guidance	72/1232	233/7206	1.24861609399e-07
ko04925	Aldosterone synthesis and secretion	40/1232	105/7206	2.52465482165e-07
ko04740	Olfactory transduction	33/1232	80/7206	2.66929799536e-07
ko05164	Influenza A	7/1232	167/7206	3.89155824507e-07
ko03013	RNA transport	7/1232	166/7206	5.71303392002e-07
ko04540	Gap junction	45/1232	128/7206	6.28509061278e-07
ko05322	Systemic lupus erythematosus	6/1232	151/7206	9.76885340324e-07
ko05168	Herpes simplex infection	9/1232	182/7206	1.10489731416e-06
ko04060	Cytokine-cytokine receptor interaction	10/1232	191/7206	1.2146909482e-06
ko04924	Renin secretion	33/1232	86/7206	1.98928462154e-06
ko04514	Cell adhesion molecules (CAMs)	44/1232	130/7206	2.80666911724e-06
ko04966	Collecting duct acid secretion	15/1232	26/7206	3.37689920217e-06
ko05030	Cocaine addiction	29/1232	73/7206	4.56966931559e-06
ko04972	Pancreatic secretion	39/1232	111/7206	4.8255902803e-06
ko04070	Phosphatidylinositol signaling system	39/1232	112/7206	5.41935842346e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1232	74/7206	5.72299163589e-06
ko04010	MAPK signaling pathway	85/1232	321/7206	1.39424845077e-05
ko05169	Epstein-Barr virus infection	14/1232	206/7206	1.91191418101e-05
ko04730	Long-term depression	29/1232	78/7206	2.32575820285e-05
ko04120	Ubiquitin mediated proteolysis	7/1232	138/7206	3.03859885055e-05
ko04976	Bile secretion	29/1232	80/7206	3.32273377354e-05
ko04621	NOD-like receptor signaling pathway	9/1232	157/7206	3.57021367072e-05
ko04745	Phototransduction - fly	17/1232	38/7206	6.33848710254e-05
ko04964	Proximal tubule bicarbonate reclamation	14/1232	29/7206	0.000102261046135
ko04610	Complement and coagulation cascades	2/1232	79/7206	0.000113023622108
ko03008	Ribosome biogenesis in eukaryotes	2/1232	79/7206	0.000113023622108
ko04750	Inflammatory mediator regulation of TRP channels	38/1232	122/7206	0.000131390068305
ko04110	Cell cycle	9/1232	145/7206	0.000132161095343
ko04260	Cardiac muscle contraction	32/1232	98/7206	0.000195766173124
ko04141	Protein processing in endoplasmic reticulum	14/1232	184/7206	0.000219426524634
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1232	79/7206	0.000219561070314
ko05110	Vibrio cholerae infection	23/1232	63/7206	0.00026422001109
ko05161	Hepatitis B	13/1232	173/7206	0.000311617282778
ko05162	Measles	7/1232	120/7206	0.000341397918206
ko05414	Dilated cardiomyopathy	34/1232	112/7206	0.000525388624507
ko04014	Ras signaling pathway	70/1232	279/7206	0.000613257862295
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1232	59/7206	0.000666998234498
ko04064	NF-kappa B signaling pathway	5/1232	96/7206	0.000880104535937
ko05205	Proteoglycans in cancer	27/1232	271/7206	0.000959197311275
ko05140	Leishmaniasis	3/1232	75/7206	0.000989465850943
ko04626	Plant-pathogen interaction	9/1232	18/7206	0.00134548285583
ko04072	Phospholipase D signaling pathway	51/1232	197/7206	0.0014803571127
ko00330	Arginine and proline metabolism	2/1232	61/7206	0.00173079877144
ko04630	Jak-STAT signaling pathway	10/1232	132/7206	0.00221434815682
ko04371	Apelin signaling pathway	46/1232	177/7206	0.0023355680193
ko04270	Vascular smooth muscle contraction	41/1232	154/7206	0.00238273410675
ko04146	Peroxisome	5/1232	89/7206	0.00253014108303
ko03420	Nucleotide excision repair	1/1232	46/7206	0.00282125024532
ko04612	Antigen processing and presentation	4/1232	77/7206	0.00334228875242
ko00480	Glutathione metabolism	2/1232	55/7206	0.00374431898115
ko05321	Inflammatory bowel disease (IBD)	2/1232	56/7206	0.00375154873936
ko05145	Toxoplasmosis	10/1232	126/7206	0.00397395498934
ko05166	HTLV-I infection	32/1232	292/7206	0.00413230525616
ko03022	Basal transcription factors	1/1232	44/7206	0.00425087512509
ko05144	Malaria	1/1232	45/7206	0.00436965452979
ko00071	Fatty acid degradation	1/1232	45/7206	0.00436965452979
ko00310	Lysine degradation	4/1232	73/7206	0.00467025038102
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1232	14/7206	0.00472241353681
ko04923	Regulation of lipolysis in adipocytes	23/1232	77/7206	0.00547489799097
ko04330	Notch signaling pathway	3/1232	62/7206	0.00622856818191
ko04622	RIG-I-like receptor signaling pathway	3/1232	62/7206	0.00622856818191
ko04916	Melanogenesis	37/1232	142/7206	0.00655672955262
ko00380	Tryptophan metabolism	2/1232	50/7206	0.00806189741924
ko00590	Arachidonic acid metabolism	2/1232	52/7206	0.00831801102786
ko04210	Apoptosis	18/1232	180/7206	0.00890095399709
ko04657	IL-17 signaling pathway	6/1232	87/7206	0.00918786999624
ko05133	Pertussis	6/1232	87/7206	0.00918786999624
ko04915	Estrogen signaling pathway	34/1232	131/7206	0.00958996242389
ko00562	Inositol phosphate metabolism	25/1232	89/7206	0.00992282954482
ko00240	Pyrimidine metabolism	9/1232	110/7206	0.0102369154378
ko05215	Prostate cancer	9/1232	111/7206	0.0103932698733
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1232	100/7206	0.0109136697471
ko04217	Necroptosis	18/1232	178/7206	0.0113612283742
ko05219	Bladder cancer	2/1232	48/7206	0.0117297853393
ko03018	RNA degradation	6/1232	84/7206	0.0124884640519
ko04710	Circadian rhythm	14/1232	43/7206	0.0128467701756
ko04115	p53 signaling pathway	5/1232	74/7206	0.0129399357284
ko01524	Platinum drug resistance	5/1232	76/7206	0.0131776893594
ko03410	Base excision repair	1/1232	38/7206	0.015031090762
ko04620	Toll-like receptor signaling pathway	8/1232	100/7206	0.0151357069235
ko05222	Small cell lung cancer	7/1232	89/7206	0.0159277058248
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1232	182/7206	0.0162002669512
ko05131	Shigellosis	6/1232	82/7206	0.0171964023722
ko04214	Apoptosis - fly	5/1232	72/7206	0.0178077687661
ko00280	Valine, leucine and isoleucine degradation	3/1232	54/7206	0.0182172763293
ko04640	Hematopoietic cell lineage	4/1232	64/7206	0.0184169170434
ko04658	Th1 and Th2 cell differentiation	8/1232	96/7206	0.0197272842481
ko04912	GnRH signaling pathway	31/1232	122/7206	0.0203701360992
ko04922	Glucagon signaling pathway	32/1232	128/7206	0.0235680674769
ko03320	PPAR signaling pathway	5/1232	69/7206	0.0244984694518
ko04930	Type II diabetes mellitus	16/1232	54/7206	0.0271154841324
ko05220	Chronic myeloid leukemia	7/1232	85/7206	0.0287702922217
ko04140	Autophagy - animal	18/1232	164/7206	0.0354882300304
ko00140	Steroid hormone biosynthesis	2/1232	41/7206	0.0359608762973
ko04933	AGE-RAGE signaling pathway in diabetic complications	14/1232	135/7206	0.0371924100302
ko04668	TNF signaling pathway	12/1232	120/7206	0.0372094394588
ko04137	Mitophagy - animal	7/1232	82/7206	0.0382149537701
ko05212	Pancreatic cancer	7/1232	83/7206	0.0386534767538
ko04918	Thyroid hormone synthesis	22/1232	86/7206	0.0429197201607
ko05340	Primary immunodeficiency	1/1232	30/7206	0.0487336478697