ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 34/289 152/7206 6.75349919205e-17 ko04713 Circadian entrainment 32/289 136/7206 1.21214447234e-16 ko04728 Dopaminergic synapse 32/289 185/7206 1.21278962183e-12 ko04721 Synaptic vesicle cycle 19/289 80/7206 2.03682254492e-10 ko04727 GABAergic synapse 22/289 110/7206 2.65055776776e-10 ko05033 Nicotine addiction 16/289 56/7206 2.89971319508e-10 ko04720 Long-term potentiation 20/289 99/7206 1.47263889688e-09 ko04725 Cholinergic synapse 25/289 160/7206 3.68635645451e-09 ko04911 Insulin secretion 21/289 117/7206 5.44137239424e-09 ko05031 Amphetamine addiction 18/289 91/7206 1.42107851538e-08 ko04024 cAMP signaling pathway 33/289 279/7206 1.62294440913e-08 ko04723 Retrograde endocannabinoid signaling 25/289 175/7206 2.40050319881e-08 ko04970 Salivary secretion 18/289 95/7206 2.89000855117e-08 ko04261 Adrenergic signaling in cardiomyocytes 27/289 205/7206 3.77053063931e-08 ko05032 Morphine addiction 19/289 110/7206 5.69197796353e-08 ko05014 Amyotrophic lateral sclerosis (ALS) 15/289 74/7206 1.67348593153e-07 ko04730 Long-term depression 15/289 78/7206 3.46591562551e-07 ko04966 Collecting duct acid secretion 9/289 26/7206 4.06018238236e-07 ko04921 Oxytocin signaling pathway 25/289 209/7206 8.00689290006e-07 ko04080 Neuroactive ligand-receptor interaction 39/289 423/7206 1.04486281694e-06 ko05120 Epithelial cell signaling in Helicobacter pylori infection 15/289 92/7206 3.12857344598e-06 ko04626 Plant-pathogen interaction 7/289 18/7206 3.37611529903e-06 ko05110 Vibrio cholerae infection 12/289 63/7206 5.87278316076e-06 ko04726 Serotonergic synapse 18/289 137/7206 7.9207112217e-06 ko04745 Phototransduction - fly 9/289 38/7206 1.38470538782e-05 ko04022 cGMP-PKG signaling pathway 23/289 216/7206 1.60837854248e-05 ko04145 Phagosome 19/289 162/7206 2.32791196456e-05 ko04971 Gastric acid secretion 14/289 98/7206 3.18090909483e-05 ko04924 Renin secretion 13/289 86/7206 3.31477579844e-05 ko04360 Axon guidance 23/289 233/7206 5.41803646413e-05 ko04371 Apelin signaling pathway 19/289 177/7206 7.99134627059e-05 ko04114 Oocyte meiosis 16/289 139/7206 0.000129328751597 ko04020 Calcium signaling pathway 24/289 265/7206 0.000162039967153 ko05167 Kaposi's sarcoma-associated herpesvirus infection 19/289 191/7206 0.000220138245341 ko05034 Alcoholism 22/289 238/7206 0.00025671612557 ko04014 Ras signaling pathway 24/289 279/7206 0.000433715067281 ko04972 Pancreatic secretion 13/289 111/7206 0.000465650687464 ko00190 Oxidative phosphorylation 14/289 127/7206 0.000530844853768 ko05030 Cocaine addiction 10/289 73/7206 0.000608992448316 ko05010 Alzheimer's disease 19/289 202/7206 0.000678109633599 ko05323 Rheumatoid arthritis 11/289 89/7206 0.000801535600799 ko04015 Rap1 signaling pathway 23/289 278/7206 0.000854708975201 ko04514 Cell adhesion molecules (CAMs) 13/289 130/7206 0.00205434319125 ko04370 VEGF signaling pathway 9/289 77/7206 0.00348372554759 ko05152 Tuberculosis 16/289 187/7206 0.00376211258959 ko05214 Glioma 9/289 79/7206 0.00414538909597 ko04740 Olfactory transduction 9/289 80/7206 0.00451107972589 ko04540 Gap junction 12/289 128/7206 0.00511783340056 ko04964 Proximal tubule bicarbonate reclamation 5/289 29/7206 0.00538939880195 ko04960 Aldosterone-regulated sodium reabsorption 6/289 41/7206 0.00543700984104 ko04973 Carbohydrate digestion and absorption 6/289 42/7206 0.0061347002723 ko04915 Estrogen signaling pathway 12/289 131/7206 0.00615321324195 ko04940 Type I diabetes mellitus 5/289 32/7206 0.00828703005248 ko04961 Endocrine and other factor-regulated calcium reabsorption 7/289 59/7206 0.00886336783919 ko04062 Chemokine signaling pathway 16/289 201/7206 0.00899695530925 ko04925 Aldosterone synthesis and secretion 10/289 105/7206 0.00918397561061 ko04912 GnRH signaling pathway 11/289 122/7206 0.00959504214823 ko04151 PI3K-Akt signaling pathway 26/289 390/7206 0.0108341536902 ko04722 Neurotrophin signaling pathway 13/289 160/7206 0.0131588116477 ko04744 Phototransduction 5/289 36/7206 0.0136231673377 ko04071 Sphingolipid signaling pathway 13/289 162/7206 0.0142563575439 ko04916 Melanogenesis 12/289 142/7206 0.0142570315743 ko04260 Cardiac muscle contraction 9/289 98/7206 0.0164066468622 ko04922 Glucagon signaling pathway 11/289 128/7206 0.0185354152424 ko04978 Mineral absorption 5/289 40/7206 0.0208923748236 ko04662 B cell receptor signaling pathway 8/289 88/7206 0.024325155322 ko04750 Inflammatory mediator regulation of TRP channels 10/289 122/7206 0.0307768788495 ko04218 Cellular senescence 13/289 177/7206 0.0309056291055 ko03040 Spliceosome 1/289 145/7206 0.0312350221246 ko05322 Systemic lupus erythematosus 1/289 151/7206 0.0323450940367 ko04742 Taste transduction 6/289 61/7206 0.0346052055864 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/289 1/7206 0.0401054676659 ko04016 MAPK signaling pathway - plant 3/289 20/7206 0.0439155392003 ko04070 Phosphatidylinositol signaling system 9/289 112/7206 0.0452536440203 ko04120 Ubiquitin mediated proteolysis 1/289 138/7206 0.0453858406273 ko00760 Nicotinate and nicotinamide metabolism 4/289 34/7206 0.0456654673189 ko00680 Methane metabolism 4/289 34/7206 0.0456654673189