ko pathway ratio_in_study ratio_in_pop p_value ko05033 Nicotine addiction 35/555 56/7206 1.13064746599e-25 ko04724 Glutamatergic synapse 53/555 152/7206 2.45569248723e-22 ko04721 Synaptic vesicle cycle 36/555 80/7206 8.19188603628e-20 ko04728 Dopaminergic synapse 52/555 185/7206 3.08313229713e-17 ko05032 Morphine addiction 39/555 110/7206 5.48172163784e-17 ko04727 GABAergic synapse 37/555 110/7206 2.53342586304e-15 ko04723 Retrograde endocannabinoid signaling 47/555 175/7206 7.71762285106e-15 ko04713 Circadian entrainment 38/555 136/7206 8.45386699145e-13 ko04080 Neuroactive ligand-receptor interaction 73/555 423/7206 2.24582801849e-11 ko04725 Cholinergic synapse 38/555 160/7206 1.7830015267e-10 ko04911 Insulin secretion 31/555 117/7206 4.95305515321e-10 ko04514 Cell adhesion molecules (CAMs) 30/555 130/7206 3.15478875051e-08 ko04261 Adrenergic signaling in cardiomyocytes 39/555 205/7206 8.26612052102e-08 ko04024 cAMP signaling pathway 47/555 279/7206 2.26561076348e-07 ko05030 Cocaine addiction 20/555 73/7206 3.43844573816e-07 ko04744 Phototransduction 13/555 36/7206 1.28983213532e-06 ko04010 MAPK signaling pathway 50/555 321/7206 1.51246989357e-06 ko04921 Oxytocin signaling pathway 37/555 209/7206 1.93854212678e-06 ko04726 Serotonergic synapse 26/555 137/7206 1.29733423835e-05 ko05031 Amphetamine addiction 20/555 91/7206 1.40118484138e-05 ko04720 Long-term potentiation 21/555 99/7206 1.5328113117e-05 ko05203 Viral carcinogenesis 5/555 277/7206 2.54464557332e-05 ko04060 Cytokine-cytokine receptor interaction 2/555 191/7206 4.74773998061e-05 ko04730 Long-term depression 17/555 78/7206 6.87501370892e-05 ko04970 Salivary secretion 19/555 95/7206 9.0755646837e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 16/555 74/7206 0.000123740380653 ko04020 Calcium signaling pathway 38/555 265/7206 0.000147341543131 ko03040 Spliceosome 1/555 145/7206 0.000206367151879 ko04360 Axon guidance 34/555 233/7206 0.000243068536622 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/555 14/7206 0.000356952879815 ko04260 Cardiac muscle contraction 18/555 98/7206 0.000420279379475 ko04966 Collecting duct acid secretion 8/555 26/7206 0.000529108182948 ko04742 Taste transduction 13/555 61/7206 0.000610889414934 ko04972 Pancreatic secretion 19/555 111/7206 0.000861938056503 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 15/555 79/7206 0.000871433713323 ko05205 Proteoglycans in cancer 8/555 271/7206 0.00153299225339 ko03013 RNA transport 3/555 166/7206 0.00167518292063 ko04120 Ubiquitin mediated proteolysis 2/555 138/7206 0.00193588007821 ko05169 Epstein-Barr virus infection 5/555 206/7206 0.00201770346044 ko04961 Endocrine and other factor-regulated calcium reabsorption 11/555 59/7206 0.00478674465925 ko05164 Influenza A 4/555 167/7206 0.00500225626056 ko04022 cGMP-PKG signaling pathway 28/555 216/7206 0.00601716158436 ko04110 Cell cycle 3/555 145/7206 0.00663240038311 ko04144 Endocytosis 40/555 342/7206 0.00671268267446 ko05168 Herpes simplex infection 5/555 182/7206 0.00706517505079 ko04932 Non-alcoholic fatty liver disease (NAFLD) 5/555 182/7206 0.00706517505079 ko05110 Vibrio cholerae infection 11/555 63/7206 0.00796656251747 ko04621 NOD-like receptor signaling pathway 4/555 157/7206 0.00954476951434 ko05215 Prostate cancer 2/555 111/7206 0.0115394905015 ko05142 Chagas disease (American trypanosomiasis) 18/555 130/7206 0.0123843016451 ko04630 Jak-STAT signaling pathway 3/555 132/7206 0.012693131469 ko05322 Systemic lupus erythematosus 4/555 151/7206 0.0131038649517 ko04925 Aldosterone synthesis and secretion 15/555 105/7206 0.0161520254441 ko04141 Protein processing in endoplasmic reticulum 6/555 184/7206 0.016976497473 ko04068 FoxO signaling pathway 5/555 167/7206 0.0177854061077 ko05414 Dilated cardiomyopathy 16/555 112/7206 0.0179383627678 ko04915 Estrogen signaling pathway 18/555 131/7206 0.0186774597401 ko04137 Mitophagy - animal 1/555 82/7206 0.0200418086666 ko04964 Proximal tubule bicarbonate reclamation 6/555 29/7206 0.0209729754563 ko04072 Phospholipase D signaling pathway 24/555 197/7206 0.0211535794909 ko04924 Renin secretion 13/555 86/7206 0.021850440113 ko04350 TGF-beta signaling pathway 2/555 103/7206 0.0234948019619 ko05161 Hepatitis B 6/555 173/7206 0.0300457098807 ko04064 NF-kappa B signaling pathway 2/555 96/7206 0.0326901633029 ko04930 Type II diabetes mellitus 9/555 54/7206 0.0338988437897 ko05410 Hypertrophic cardiomyopathy (HCM) 14/555 100/7206 0.0344437672088 ko04071 Sphingolipid signaling pathway 20/555 162/7206 0.0351553128325 ko04510 Focal adhesion 10/555 240/7206 0.0356384972654 ko00513 Various types of N-glycan biosynthesis 7/555 42/7206 0.0394544035901 ko04973 Carbohydrate digestion and absorption 7/555 42/7206 0.0394544035901 ko04214 Apoptosis - fly 1/555 72/7206 0.0423399591715 ko00240 Pyrimidine metabolism 3/555 110/7206 0.0464045452706