ko pathway ratio_in_study ratio_in_pop p_value ko04976 Bile secretion 23/433 80/7206 1.28900515681e-10 ko04974 Protein digestion and absorption 21/433 96/7206 1.63497174884e-07 ko00350 Tyrosine metabolism 12/433 33/7206 2.12536689126e-07 ko05166 HTLV-I infection 1/433 292/7206 4.16639111869e-07 ko00360 Phenylalanine metabolism 8/433 17/7206 2.39530279541e-06 ko04975 Fat digestion and absorption 11/433 35/7206 3.63739373118e-06 ko00380 Tryptophan metabolism 13/433 50/7206 5.09920993845e-06 ko02010 ABC transporters 11/433 39/7206 1.17351759836e-05 ko04360 Axon guidance 1/433 233/7206 1.50086041838e-05 ko00260 Glycine, serine and threonine metabolism 12/433 48/7206 1.82518262547e-05 ko05200 Pathways in cancer 10/433 492/7206 2.00903499428e-05 ko00983 Drug metabolism - other enzymes 11/433 42/7206 2.5432145253e-05 ko04744 Phototransduction 10/433 36/7206 3.41355808566e-05 ko04614 Renin-angiotensin system 7/433 18/7206 4.80200215386e-05 ko04610 Complement and coagulation cascades 15/433 79/7206 5.7879255883e-05 ko04978 Mineral absorption 10/433 40/7206 9.16119930015e-05 ko00140 Steroid hormone biosynthesis 10/433 41/7206 0.000114768411317 ko04080 Neuroactive ligand-receptor interaction 45/433 423/7206 0.000130070341952 ko00950 Isoquinoline alkaloid biosynthesis 5/433 10/7206 0.000149938230549 ko04977 Vitamin digestion and absorption 7/433 22/7206 0.000208491143375 ko04141 Protein processing in endoplasmic reticulum 1/433 184/7206 0.000221669707931 ko04390 Hippo signaling pathway 1/433 188/7206 0.000235838631947 ko05203 Viral carcinogenesis 4/433 277/7206 0.000256333692128 ko04972 Pancreatic secretion 17/433 111/7206 0.000304491955283 ko04550 Signaling pathways regulating pluripotency of stem cells 1/433 165/7206 0.000707626037641 ko03320 PPAR signaling pathway 12/433 69/7206 0.000730673280012 ko04146 Peroxisome 14/433 89/7206 0.000776695437734 ko00643 Styrene degradation 3/433 4/7206 0.000823594697726 ko04740 Olfactory transduction 13/433 80/7206 0.000867940844948 ko04742 Taste transduction 11/433 61/7206 0.000882158193914 ko01230 Biosynthesis of amino acids 13/433 85/7206 0.00154757226722 ko00230 Purine metabolism 23/433 194/7206 0.00176942815117 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 3/433 5/7206 0.00196707769107 ko04144 Endocytosis 8/433 342/7206 0.00218438197492 ko05169 Epstein-Barr virus infection 3/433 206/7206 0.00251512599602 ko00340 Histidine metabolism 6/433 25/7206 0.00302351959097 ko05224 Breast cancer 2/433 174/7206 0.00304942953249 ko00830 Retinol metabolism 8/433 42/7206 0.00307899362824 ko00330 Arginine and proline metabolism 10/433 61/7206 0.00313969519863 ko04120 Ubiquitin mediated proteolysis 1/433 138/7206 0.00322829592379 ko04010 MAPK signaling pathway 8/433 321/7206 0.00379571602758 ko00592 alpha-Linolenic acid metabolism 5/433 19/7206 0.00440663946185 ko04924 Renin secretion 12/433 86/7206 0.00502914298405 ko04726 Serotonergic synapse 17/433 137/7206 0.00520878044283 ko05016 Huntington's disease 4/433 215/7206 0.00525416706404 ko00120 Primary bile acid biosynthesis 5/433 20/7206 0.00559053449021 ko00250 Alanine, aspartate and glutamate metabolism 7/433 38/7206 0.00670066124886 ko05168 Herpes simplex infection 3/433 182/7206 0.00682407324357 ko04932 Non-alcoholic fatty liver disease (NAFLD) 3/433 182/7206 0.00682407324357 ko00591 Linoleic acid metabolism 5/433 22/7206 0.0085990448007 ko04218 Cellular senescence 3/433 177/7206 0.00957637668452 ko04310 Wnt signaling pathway 3/433 181/7206 0.010002821785 ko05162 Measles 1/433 120/7206 0.0101562793272 ko04151 PI3K-Akt signaling pathway 12/433 390/7206 0.0111819978397 ko00590 Arachidonic acid metabolism 8/433 52/7206 0.0116240394704 ko00561 Glycerolipid metabolism 9/433 63/7206 0.0123092729579 ko00220 Arginine biosynthesis 5/433 24/7206 0.0125729135838 ko00680 Methane metabolism 6/433 34/7206 0.0145387036093 ko00500 Starch and sucrose metabolism 6/433 35/7206 0.0166838766928 ko04114 Oocyte meiosis 2/433 139/7206 0.0174006106404 ko05202 Transcriptional misregulation in cancer 4/433 188/7206 0.0187133556322 ko03013 RNA transport 3/433 166/7206 0.0189321746725 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/433 4/7206 0.0199311689853 ko00965 Betalain biosynthesis 2/433 4/7206 0.0199311689853 ko04015 Rap1 signaling pathway 8/433 278/7206 0.020319117821 ko04520 Adherens junction 1/433 103/7206 0.0208024074908 ko04914 Progesterone-mediated oocyte maturation 1/433 104/7206 0.0208406030698 ko00982 Drug metabolism - cytochrome P450 6/433 37/7206 0.0216080789432 ko05204 Chemical carcinogenesis 7/433 48/7206 0.0233811565376 ko04020 Calcium signaling pathway 25/433 265/7206 0.0240662685184 ko00910 Nitrogen metabolism 4/433 19/7206 0.0242403307644 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 3/433 11/7206 0.0247536771059 ko04150 mTOR signaling pathway 4/433 184/7206 0.0259901012803 ko04722 Neurotrophin signaling pathway 3/433 160/7206 0.0264444639333 ko04964 Proximal tubule bicarbonate reclamation 5/433 29/7206 0.0274797847156 ko05211 Renal cell carcinoma 1/433 96/7206 0.0300610930497 ko00232 Caffeine metabolism 2/433 5/7206 0.0319072298482 ko05010 Alzheimer's disease 5/433 202/7206 0.0336560909569 ko00100 Steroid biosynthesis 4/433 21/7206 0.0340605487554 ko04660 T cell receptor signaling pathway 2/433 124/7206 0.034090067157 ko05418 Fluid shear stress and atherosclerosis 4/433 173/7206 0.0344046349603 ko05161 Hepatitis B 4/433 173/7206 0.0344046349603 ko05322 Systemic lupus erythematosus 3/433 151/7206 0.0355382763965 ko04217 Necroptosis 4/433 178/7206 0.0355652965161 ko01200 Carbon metabolism 14/433 128/7206 0.0356303713288 ko04973 Carbohydrate digestion and absorption 6/433 42/7206 0.03796310067 ko00052 Galactose metabolism 5/433 33/7206 0.0451991117543 ko00362 Benzoate degradation 2/433 6/7206 0.0459813049835 ko05164 Influenza A 4/433 167/7206 0.0465544902968 ko00770 Pantothenate and CoA biosynthesis 3/433 14/7206 0.0477867130246 ko04971 Gastric acid secretion 11/433 98/7206 0.0486690238975 ko04668 TNF signaling pathway 2/433 120/7206 0.0490069655365