ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	188/1138	423/7206	1.09049803847e-47
ko04724	Glutamatergic synapse	89/1138	152/7206	4.36202590901e-34
ko05033	Nicotine addiction	48/1138	56/7206	5.59876417842e-31
ko05032	Morphine addiction	66/1138	110/7206	2.33165384442e-26
ko04727	GABAergic synapse	65/1138	110/7206	1.92985583594e-25
ko04721	Synaptic vesicle cycle	52/1138	80/7206	2.43421593439e-23
ko04713	Circadian entrainment	71/1138	136/7206	2.94646764213e-23
ko04728	Dopaminergic synapse	84/1138	185/7206	4.56276163978e-22
ko04725	Cholinergic synapse	73/1138	160/7206	1.86721031351e-19
ko04723	Retrograde endocannabinoid signaling	77/1138	175/7206	2.68529513311e-19
ko04024	cAMP signaling pathway	98/1138	279/7206	6.74907746226e-16
ko04744	Phototransduction	27/1138	36/7206	3.86044104658e-15
ko04742	Taste transduction	36/1138	61/7206	1.33325764297e-14
ko04020	Calcium signaling pathway	91/1138	265/7206	2.90351941376e-14
ko04911	Insulin secretion	52/1138	117/7206	1.25497817948e-13
ko04921	Oxytocin signaling pathway	76/1138	209/7206	1.45311877499e-13
ko04726	Serotonergic synapse	57/1138	137/7206	2.62219868026e-13
ko05031	Amphetamine addiction	41/1138	91/7206	2.98839650157e-11
ko04720	Long-term potentiation	43/1138	99/7206	4.33568507637e-11
ko04261	Adrenergic signaling in cardiomyocytes	69/1138	205/7206	1.46564299413e-10
ko03040	Spliceosome	1/1138	145/7206	5.15134904132e-10
ko04970	Salivary secretion	37/1138	95/7206	3.56085735629e-08
ko05203	Viral carcinogenesis	15/1138	277/7206	8.57213613858e-08
ko04925	Aldosterone synthesis and secretion	38/1138	105/7206	2.38724573113e-07
ko05168	Herpes simplex infection	7/1138	182/7206	4.68281380609e-07
ko04740	Olfactory transduction	31/1138	80/7206	5.22219833883e-07
ko05030	Cocaine addiction	29/1138	73/7206	6.57716934581e-07
ko04966	Collecting duct acid secretion	15/1138	26/7206	1.19375913806e-06
ko04060	Cytokine-cytokine receptor interaction	9/1138	191/7206	2.58354513318e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1138	74/7206	3.21804353191e-06
ko04971	Gastric acid secretion	34/1138	98/7206	3.795727898e-06
ko03013	RNA transport	7/1138	166/7206	4.15732786765e-06
ko04022	cGMP-PKG signaling pathway	60/1138	216/7206	6.33547264773e-06
ko05322	Systemic lupus erythematosus	6/1138	151/7206	7.3983245644e-06
ko04120	Ubiquitin mediated proteolysis	5/1138	138/7206	8.77708490433e-06
ko04360	Axon guidance	63/1138	233/7206	9.11343602666e-06
ko04621	NOD-like receptor signaling pathway	7/1138	157/7206	1.19582182017e-05
ko04745	Phototransduction - fly	17/1138	38/7206	2.20380668099e-05
ko04924	Renin secretion	29/1138	86/7206	3.49758409489e-05
ko04514	Cell adhesion molecules (CAMs)	39/1138	130/7206	4.41229924902e-05
ko05164	Influenza A	9/1138	167/7206	5.60924781444e-05
ko04010	MAPK signaling pathway	78/1138	321/7206	5.76921119136e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1138	79/7206	6.01267428834e-05
ko05110	Vibrio cholerae infection	23/1138	63/7206	6.57534952836e-05
ko04070	Phosphatidylinositol signaling system	34/1138	112/7206	0.000110043577623
ko04064	NF-kappa B signaling pathway	3/1138	96/7206	0.000111462278201
ko04730	Long-term depression	26/1138	78/7206	0.000114404754948
ko05161	Hepatitis B	11/1138	173/7206	0.000200361711384
ko05414	Dilated cardiomyopathy	33/1138	112/7206	0.000211981211861
ko04072	Phospholipase D signaling pathway	51/1138	197/7206	0.000217653242145
ko04610	Complement and coagulation cascades	2/1138	79/7206	0.000265946336371
ko03008	Ribosome biogenesis in eukaryotes	2/1138	79/7206	0.000265946336371
ko05169	Epstein-Barr virus infection	15/1138	206/7206	0.000305046300625
ko04540	Gap junction	36/1138	128/7206	0.000330735166228
ko05162	Measles	6/1138	120/7206	0.000357506108825
ko04141	Protein processing in endoplasmic reticulum	13/1138	184/7206	0.000459090125286
ko05205	Proteoglycans in cancer	23/1138	271/7206	0.000461501826502
ko04972	Pancreatic secretion	32/1138	111/7206	0.000522316799909
ko04915	Estrogen signaling pathway	36/1138	131/7206	0.000603262011185
ko05140	Leishmaniasis	2/1138	75/7206	0.000612596551738
ko04260	Cardiac muscle contraction	29/1138	98/7206	0.000646363054596
ko04110	Cell cycle	9/1138	145/7206	0.000740110894365
ko04626	Plant-pathogen interaction	9/1138	18/7206	0.000742244585192
ko00480	Glutathione metabolism	1/1138	55/7206	0.00133828829245
ko04014	Ras signaling pathway	64/1138	279/7206	0.00140164036625
ko04976	Bile secretion	24/1138	80/7206	0.00165559998703
ko04146	Peroxisome	4/1138	89/7206	0.00179522950097
ko04612	Antigen processing and presentation	3/1138	77/7206	0.00234457932443
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1138	14/7206	0.0029649653814
ko04964	Proximal tubule bicarbonate reclamation	11/1138	29/7206	0.00320555521202
ko04214	Apoptosis - fly	3/1138	72/7206	0.00322126745452
ko00590	Arachidonic acid metabolism	1/1138	52/7206	0.00324801305385
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1138	59/7206	0.00376418862001
ko04923	Regulation of lipolysis in adipocytes	22/1138	77/7206	0.00411999521612
ko00240	Pyrimidine metabolism	7/1138	110/7206	0.00513650348488
ko04750	Inflammatory mediator regulation of TRP channels	31/1138	122/7206	0.0055165942464
ko04510	Focal adhesion	23/1138	240/7206	0.00666987861372
ko05166	HTLV-I infection	30/1138	292/7206	0.00678774816308
ko05144	Malaria	1/1138	45/7206	0.00680284221006
ko00071	Fatty acid degradation	1/1138	45/7206	0.00680284221006
ko03420	Nucleotide excision repair	1/1138	46/7206	0.00697567084246
ko04630	Jak-STAT signaling pathway	10/1138	132/7206	0.00757544809514
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1138	100/7206	0.00809383902142
ko05321	Inflammatory bowel disease (IBD)	2/1138	56/7206	0.00872287884185
ko04371	Apelin signaling pathway	41/1138	177/7206	0.00887028518195
ko04210	Apoptosis	16/1138	180/7206	0.00927273593521
ko04115	p53 signaling pathway	4/1138	74/7206	0.00983492504589
ko03018	RNA degradation	5/1138	84/7206	0.00986955298492
ko01524	Platinum drug resistance	4/1138	76/7206	0.0102648525757
ko03022	Basal transcription factors	1/1138	44/7206	0.0107543792386
ko05206	MicroRNAs in cancer	16/1138	177/7206	0.011826086162
ko05145	Toxoplasmosis	10/1138	126/7206	0.0131373556445
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1138	182/7206	0.0133184928868
ko04622	RIG-I-like receptor signaling pathway	3/1138	62/7206	0.0134647768635
ko05131	Shigellosis	5/1138	82/7206	0.0137813961431
ko00310	Lysine degradation	4/1138	73/7206	0.0141965196722
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1138	40/7206	0.0152384544426
ko04657	IL-17 signaling pathway	6/1138	87/7206	0.0177849625966
ko05133	Pertussis	6/1138	87/7206	0.0177849625966
ko05222	Small cell lung cancer	6/1138	89/7206	0.018120489431
ko00330	Arginine and proline metabolism	3/1138	61/7206	0.019933903588
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1138	92/7206	0.0205067349239
ko04350	TGF-beta signaling pathway	8/1138	103/7206	0.0206093331399
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1138	15/7206	0.0212632608461
ko04668	TNF signaling pathway	10/1138	120/7206	0.022473332502
ko00982	Drug metabolism - cytochrome P450	1/1138	37/7206	0.0226240063357
ko00630	Glyoxylate and dicarboxylate metabolism	1/1138	38/7206	0.0230665739414
ko05215	Prostate cancer	9/1138	111/7206	0.0249173752737
ko05219	Bladder cancer	2/1138	48/7206	0.0265097175677
ko05418	Fluid shear stress and atherosclerosis	17/1138	173/7206	0.0267107074933
ko00562	Inositol phosphate metabolism	22/1138	89/7206	0.0272157055352
ko05202	Transcriptional misregulation in cancer	19/1138	188/7206	0.0326741849678
ko04912	GnRH signaling pathway	28/1138	122/7206	0.0332166693809
ko00640	Propanoate metabolism	1/1138	34/7206	0.0336466955974
ko04710	Circadian rhythm	12/1138	43/7206	0.0359219207233
ko05016	Huntington's disease	23/1138	215/7206	0.0366204948698
ko00512	Mucin type O-glycan biosynthesis	9/1138	29/7206	0.0368033271094
ko04640	Hematopoietic cell lineage	4/1138	64/7206	0.0371030572894
ko04922	Glucagon signaling pathway	29/1138	128/7206	0.0372379968035
ko00280	Valine, leucine and isoleucine degradation	3/1138	54/7206	0.0379585378269
ko04114	Oocyte meiosis	31/1138	139/7206	0.0447744247307
ko05200	Pathways in cancer	62/1138	492/7206	0.0469020446007
ko03320	PPAR signaling pathway	5/1138	69/7206	0.0472114730272
ko04658	Th1 and Th2 cell differentiation	8/1138	96/7206	0.0473719960206
ko04062	Chemokine signaling pathway	42/1138	201/7206	0.0494953360623