ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 33/309 134/7206 6.84755876819e-17 ko04060 Cytokine-cytokine receptor interaction 37/309 191/7206 3.61754747823e-15 ko04064 NF-kappa B signaling pathway 25/309 96/7206 1.17226200177e-13 ko04621 NOD-like receptor signaling pathway 31/309 157/7206 4.2197739596e-13 ko05164 Influenza A 30/309 167/7206 1.31753309357e-11 ko05145 Toxoplasmosis 22/309 126/7206 1.37602510811e-08 ko04622 RIG-I-like receptor signaling pathway 15/309 62/7206 3.2510906264e-08 ko05168 Herpes simplex infection 26/309 182/7206 4.94489144302e-08 ko05161 Hepatitis B 25/309 173/7206 7.18461111498e-08 ko04650 Natural killer cell mediated cytotoxicity 18/309 97/7206 1.13165633253e-07 ko05162 Measles 20/309 120/7206 1.42726946341e-07 ko04660 T cell receptor signaling pathway 20/309 124/7206 2.48993111603e-07 ko04062 Chemokine signaling pathway 26/309 201/7206 3.74335742478e-07 ko04659 Th17 cell differentiation 18/309 106/7206 4.57449337027e-07 ko05140 Leishmaniasis 15/309 75/7206 4.79889370291e-07 ko04658 Th1 and Th2 cell differentiation 17/309 96/7206 5.17660497681e-07 ko04657 IL-17 signaling pathway 16/309 87/7206 6.61503114252e-07 ko04668 TNF signaling pathway 19/309 120/7206 6.72930068941e-07 ko04623 Cytosolic DNA-sensing pathway 11/309 41/7206 7.52615465723e-07 ko04662 B cell receptor signaling pathway 16/309 88/7206 7.77565560655e-07 ko04620 Toll-like receptor signaling pathway 17/309 100/7206 9.44823405455e-07 ko05167 Kaposi's sarcoma-associated herpesvirus infection 24/309 191/7206 1.81726279461e-06 ko04217 Necroptosis 22/309 178/7206 6.50950388037e-06 ko05160 Hepatitis C 20/309 153/7206 7.38274260484e-06 ko04630 Jak-STAT signaling pathway 18/309 132/7206 1.17797605969e-05 ko05152 Tuberculosis 22/309 187/7206 1.44954326073e-05 ko05321 Inflammatory bowel disease (IBD) 11/309 56/7206 1.99261327956e-05 ko04666 Fc gamma R-mediated phagocytosis 16/309 122/7206 5.8788770723e-05 ko05133 Pertussis 13/309 87/7206 7.51035352902e-05 ko04672 Intestinal immune network for IgA production 8/309 37/7206 0.000135636970035 ko05340 Primary immunodeficiency 7/309 30/7206 0.000216134335984 ko04640 Hematopoietic cell lineage 10/309 64/7206 0.00035039690151 ko05323 Rheumatoid arthritis 12/309 89/7206 0.000380699627141 ko05142 Chagas disease (American trypanosomiasis) 15/309 130/7206 0.000419863414022 ko04611 Platelet activation 17/309 163/7206 0.000584765865996 ko05131 Shigellosis 11/309 82/7206 0.000693111704103 ko05150 Staphylococcus aureus infection 7/309 36/7206 0.000710343770397 ko04210 Apoptosis 18/309 180/7206 0.0010118814027 ko05144 Malaria 7/309 45/7206 0.00277541202617 ko05330 Allograft rejection 5/309 24/7206 0.0030432395068 ko05134 Legionellosis 9/309 74/7206 0.00414036546515 ko05310 Asthma 4/309 17/7206 0.0050651023567 ko04612 Antigen processing and presentation 9/309 77/7206 0.00540350000803 ko05332 Graft-versus-host disease 4/309 18/7206 0.00629570854835 ko04610 Complement and coagulation cascades 9/309 79/7206 0.00639866520538 ko04512 ECM-receptor interaction 9/309 79/7206 0.00639866520538 ko04723 Retrograde endocannabinoid signaling 1/309 175/7206 0.0071672056344 ko00140 Steroid hormone biosynthesis 6/309 41/7206 0.0074944704502 ko04933 AGE-RAGE signaling pathway in diabetic complications 13/309 135/7206 0.00762339804169 ko05132 Salmonella infection 10/309 98/7206 0.00898527408409 ko05146 Amoebiasis 10/309 99/7206 0.00962748467912 ko04145 Phagosome 14/309 162/7206 0.0102943254066 ko05143 African trypanosomiasis 5/309 32/7206 0.0108988023303 ko05166 HTLV-I infection 22/309 292/7206 0.0109992533462 ko05418 Fluid shear stress and atherosclerosis 15/309 173/7206 0.0113527373314 ko05034 Alcoholism 3/309 238/7206 0.0136929323459 ko04664 Fc epsilon RI signaling pathway 8/309 77/7206 0.0168042985737 ko05169 Epstein-Barr virus infection 16/309 206/7206 0.0211245821597 ko04110 Cell cycle 1/309 145/7206 0.0215853372572 ko04728 Dopaminergic synapse 2/309 185/7206 0.0252470505001 ko05212 Pancreatic cancer 8/309 83/7206 0.0253018394146 ko05016 Huntington's disease 3/309 215/7206 0.0260674082387 ko05416 Viral myocarditis 6/309 55/7206 0.0293902265062 ko04726 Serotonergic synapse 1/309 137/7206 0.0312180684192 ko00051 Fructose and mannose metabolism 5/309 42/7206 0.0325733329198 ko05320 Autoimmune thyroid disease 4/309 29/7206 0.0338054698612 ko04670 Leukocyte transendothelial migration 12/309 151/7206 0.0383073329921 ko04940 Type I diabetes mellitus 4/309 32/7206 0.0463443535536 ko04080 Neuroactive ligand-receptor interaction 10/309 423/7206 0.0466690043127 ko04931 Insulin resistance 11/309 137/7206 0.0497678552079