ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko03040	Spliceosome	87/801	145/7206	4.87526602382e-47
ko03013	RNA transport	73/801	166/7206	9.39962565809e-28
ko04110	Cell cycle	61/801	145/7206	4.32253744967e-22
ko04080	Neuroactive ligand-receptor interaction	1/801	423/7206	4.54646006422e-21
ko03440	Homologous recombination	30/801	41/7206	1.38260667712e-20
ko05322	Systemic lupus erythematosus	58/801	151/7206	9.38517541911e-19
ko04111	Cell cycle - yeast	42/801	90/7206	1.43092213151e-17
ko03008	Ribosome biogenesis in eukaryotes	38/801	79/7206	1.43752194636e-16
ko03460	Fanconi anemia pathway	30/801	51/7206	1.67060249455e-16
ko03030	DNA replication	25/801	38/7206	1.30790128924e-15
ko04113	Meiosis - yeast	30/801	70/7206	1.00332558349e-11
ko04020	Calcium signaling pathway	2/801	265/7206	2.04199617051e-11
ko00240	Pyrimidine metabolism	38/801	110/7206	4.63731395169e-11
ko03430	Mismatch repair	15/801	22/7206	3.48051440758e-10
ko03420	Nucleotide excision repair	22/801	46/7206	4.52227710616e-10
ko05034	Alcoholism	60/801	238/7206	6.2144178659e-10
ko03018	RNA degradation	29/801	84/7206	9.60838636611e-09
ko04060	Cytokine-cytokine receptor interaction	2/801	191/7206	6.76277867768e-08
ko03020	RNA polymerase	15/801	29/7206	7.44685094113e-08
ko05203	Viral carcinogenesis	61/801	277/7206	8.80089939879e-08
ko03015	mRNA surveillance pathway	29/801	93/7206	1.25151839606e-07
ko05012	Parkinson's disease	1/801	155/7206	3.87562520442e-07
ko04723	Retrograde endocannabinoid signaling	2/801	175/7206	5.27141264267e-07
ko04724	Glutamatergic synapse	1/801	152/7206	5.968344089e-07
ko04144	Endocytosis	13/801	342/7206	9.68222829326e-07
ko03410	Base excision repair	16/801	38/7206	9.8034390491e-07
ko05010	Alzheimer's disease	4/801	202/7206	1.16876098196e-06
ko04151	PI3K-Akt signaling pathway	17/801	390/7206	1.8591116572e-06
ko04713	Circadian entrainment	1/801	136/7206	2.90654453958e-06
ko03022	Basal transcription factors	16/801	44/7206	9.63734375988e-06
ko04932	Non-alcoholic fatty liver disease (NAFLD)	4/801	182/7206	1.12820504548e-05
ko04725	Cholinergic synapse	3/801	160/7206	1.76170146638e-05
ko04911	Insulin secretion	1/801	117/7206	2.19784716171e-05
ko04261	Adrenergic signaling in cardiomyocytes	6/801	205/7206	2.29892544496e-05
ko04024	cAMP signaling pathway	11/801	279/7206	2.34812966527e-05
ko04022	cGMP-PKG signaling pathway	7/801	216/7206	3.67513910082e-05
ko04728	Dopaminergic synapse	5/801	185/7206	4.09797300346e-05
ko04727	GABAergic synapse	1/801	110/7206	4.90099292899e-05
ko05032	Morphine addiction	1/801	110/7206	4.90099292899e-05
ko04514	Cell adhesion molecules (CAMs)	2/801	130/7206	5.50194357302e-05
ko04921	Oxytocin signaling pathway	7/801	209/7206	7.2837980501e-05
ko00190	Oxidative phosphorylation	2/801	127/7206	8.20349198792e-05
ko04621	NOD-like receptor signaling pathway	4/801	157/7206	9.65271976182e-05
ko04270	Vascular smooth muscle contraction	4/801	154/7206	0.00013787391331
ko04668	TNF signaling pathway	2/801	120/7206	0.000177815064792
ko04260	Cardiac muscle contraction	1/801	98/7206	0.000251238292214
ko05414	Dilated cardiomyopathy	2/801	112/7206	0.000372878824868
ko04970	Salivary secretion	1/801	95/7206	0.000383297963625
ko04920	Adipocytokine signaling pathway	1/801	89/7206	0.000535033885096
ko05031	Amphetamine addiction	1/801	91/7206	0.000559722372372
ko04218	Cellular senescence	35/801	177/7206	0.000602552682493
ko04750	Inflammatory mediator regulation of TRP channels	3/801	122/7206	0.000688304379862
ko04010	MAPK signaling pathway	18/801	321/7206	0.000724211564619
ko04924	Renin secretion	1/801	86/7206	0.000799378731524
ko04726	Serotonergic synapse	4/801	137/7206	0.000817850020186
ko04114	Oocyte meiosis	29/801	139/7206	0.000873349505929
ko04611	Platelet activation	6/801	163/7206	0.000934354078982
ko00230	Purine metabolism	37/801	194/7206	0.00103444291968
ko04510	Focal adhesion	12/801	240/7206	0.00112534844481
ko05410	Hypertrophic cardiomyopathy (HCM)	2/801	100/7206	0.00113566723497
ko04914	Progesterone-mediated oocyte maturation	23/801	104/7206	0.00130071521799
ko04120	Ubiquitin mediated proteolysis	28/801	138/7206	0.00142839074716
ko04971	Gastric acid secretion	2/801	98/7206	0.00169869950729
ko05145	Toxoplasmosis	4/801	126/7206	0.00229954237298
ko04931	Insulin resistance	5/801	137/7206	0.00238191578728
ko03060	Protein export	8/801	23/7206	0.00239718421802
ko04015	Rap1 signaling pathway	16/801	278/7206	0.00243944536215
ko00010	Glycolysis / Gluconeogenesis	1/801	74/7206	0.00258091290842
ko05166	HTLV-I infection	49/801	292/7206	0.00303461334206
ko04380	Osteoclast differentiation	5/801	134/7206	0.00329867709424
ko04371	Apelin signaling pathway	8/801	177/7206	0.00332277064913
ko04146	Peroxisome	2/801	89/7206	0.00345190348878
ko03450	Non-homologous end-joining	6/801	15/7206	0.00382555681636
ko05030	Cocaine addiction	1/801	73/7206	0.00399831990219
ko04925	Aldosterone synthesis and secretion	3/801	105/7206	0.00418939964036
ko04915	Estrogen signaling pathway	5/801	131/7206	0.00458159838492
ko04918	Thyroid hormone synthesis	2/801	86/7206	0.00501980997225
ko04922	Glucagon signaling pathway	5/801	128/7206	0.0063777711749
ko04658	Th1 and Th2 cell differentiation	3/801	96/7206	0.00811266592886
ko04640	Hematopoietic cell lineage	1/801	64/7206	0.00832581521594
ko04062	Chemokine signaling pathway	11/801	201/7206	0.0083772796649
ko04972	Pancreatic secretion	4/801	111/7206	0.00873368946829
ko05152	Tuberculosis	10/801	187/7206	0.0090296709423
ko05169	Epstein-Barr virus infection	35/801	206/7206	0.00939555133881
ko05418	Fluid shear stress and atherosclerosis	9/801	173/7206	0.00968999314577
ko04923	Regulation of lipolysis in adipocytes	2/801	77/7206	0.01026752184
ko04152	AMPK signaling pathway	8/801	161/7206	0.0105174365745
ko04721	Synaptic vesicle cycle	2/801	80/7206	0.0107211262149
ko04976	Bile secretion	2/801	80/7206	0.0107211262149
ko04014	Ras signaling pathway	18/801	279/7206	0.0111244438596
ko04659	Th17 cell differentiation	4/801	106/7206	0.0118516629314
ko01212	Fatty acid metabolism	1/801	60/7206	0.0122104630844
ko05202	Transcriptional misregulation in cancer	32/801	188/7206	0.0130555066324
ko05168	Herpes simplex infection	31/801	182/7206	0.0160919274586
ko04139	Mitophagy - yeast	9/801	37/7206	0.017523989344
ko05321	Inflammatory bowel disease (IBD)	1/801	56/7206	0.0179068086423
ko04070	Phosphatidylinositol signaling system	5/801	112/7206	0.0218916268923
ko04620	Toll-like receptor signaling pathway	4/801	100/7206	0.0231119889032
ko04530	Tight junction	15/801	228/7206	0.0243152989069
ko04933	AGE-RAGE signaling pathway in diabetic complications	7/801	135/7206	0.0259476663135
ko04912	GnRH signaling pathway	6/801	122/7206	0.0280005462527
ko04066	HIF-1 signaling pathway	6/801	123/7206	0.0284191103892
ko04512	ECM-receptor interaction	3/801	79/7206	0.0309686694155
ko04360	Axon guidance	16/801	233/7206	0.0339315738003
ko04712	Circadian rhythm - plant	3/801	7/7206	0.0339750702639
ko05142	Chagas disease (American trypanosomiasis)	7/801	130/7206	0.0339996870347
ko04630	Jak-STAT signaling pathway	7/801	132/7206	0.0345705872658
ko05167	Kaposi's sarcoma-associated herpesvirus infection	12/801	191/7206	0.0346683789343
ko04810	Regulation of actin cytoskeleton	19/801	264/7206	0.0362919062505
ko00260	Glycine, serine and threonine metabolism	1/801	48/7206	0.0384307547229
ko04072	Phospholipase D signaling pathway	13/801	197/7206	0.0385044501659
ko04115	p53 signaling pathway	14/801	74/7206	0.0398233181178
ko00561	Glycerolipid metabolism	2/801	63/7206	0.0424458128697
ko00600	Sphingolipid metabolism	2/801	63/7206	0.0424458128697
ko01200	Carbon metabolism	7/801	128/7206	0.0453243586234
ko04540	Gap junction	7/801	128/7206	0.0453243586234