ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 33/224 191/7206 2.86193409364e-16 ko05164 Influenza A 30/224 167/7206 2.42328260114e-15 ko04621 NOD-like receptor signaling pathway 29/224 157/7206 3.41154085727e-15 ko05340 Primary immunodeficiency 14/224 30/7206 4.91793842711e-14 ko05162 Measles 24/224 120/7206 1.53079071831e-13 ko05168 Herpes simplex infection 29/224 182/7206 1.88368521652e-13 ko05140 Leishmaniasis 18/224 75/7206 7.39051519009e-12 ko04380 Osteoclast differentiation 23/224 134/7206 1.44738271009e-11 ko05152 Tuberculosis 27/224 187/7206 1.51077676901e-11 ko05145 Toxoplasmosis 22/224 126/7206 2.90031146716e-11 ko04064 NF-kappa B signaling pathway 19/224 96/7206 7.18517232664e-11 ko04612 Antigen processing and presentation 17/224 77/7206 1.20948297991e-10 ko04620 Toll-like receptor signaling pathway 19/224 100/7206 1.51650517389e-10 ko05320 Autoimmune thyroid disease 11/224 29/7206 4.33683036258e-10 ko05330 Allograft rejection 10/224 24/7206 9.24181609105e-10 ko04217 Necroptosis 24/224 178/7206 9.35580211832e-10 ko05321 Inflammatory bowel disease (IBD) 14/224 56/7206 9.57089344324e-10 ko04659 Th17 cell differentiation 18/224 106/7206 3.16938211816e-09 ko04660 T cell receptor signaling pathway 19/224 124/7206 6.76365741763e-09 ko05332 Graft-versus-host disease 8/224 18/7206 2.57617124283e-08 ko04658 Th1 and Th2 cell differentiation 16/224 96/7206 3.24222089743e-08 ko04650 Natural killer cell mediated cytotoxicity 16/224 97/7206 3.77677386697e-08 ko05133 Pertussis 15/224 87/7206 5.52912659167e-08 ko05161 Hepatitis B 21/224 173/7206 7.30019845117e-08 ko05150 Staphylococcus aureus infection 10/224 36/7206 8.62710599689e-08 ko04672 Intestinal immune network for IgA production 10/224 37/7206 1.15036902757e-07 ko04062 Chemokine signaling pathway 22/224 201/7206 2.26716267107e-07 ko05323 Rheumatoid arthritis 14/224 89/7206 5.05896606619e-07 ko04630 Jak-STAT signaling pathway 17/224 132/7206 5.79222526153e-07 ko05142 Chagas disease (American trypanosomiasis) 16/224 130/7206 2.32365336211e-06 ko04940 Type I diabetes mellitus 8/224 32/7206 4.24734540013e-06 ko05144 Malaria 9/224 45/7206 7.71144543974e-06 ko04145 Phagosome 17/224 162/7206 1.00967924099e-05 ko04210 Apoptosis 18/224 180/7206 1.08233337719e-05 ko04622 RIG-I-like receptor signaling pathway 10/224 62/7206 1.79573467148e-05 ko04668 TNF signaling pathway 14/224 120/7206 1.88667516149e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 18/224 191/7206 2.44665025994e-05 ko04623 Cytosolic DNA-sensing pathway 8/224 41/7206 3.03002034677e-05 ko05160 Hepatitis C 15/224 153/7206 7.5274003095e-05 ko05310 Asthma 5/224 17/7206 0.00012650180759 ko04640 Hematopoietic cell lineage 9/224 64/7206 0.000143416355441 ko03050 Proteasome 8/224 54/7206 0.000232987854358 ko05416 Viral myocarditis 8/224 55/7206 0.000265459521677 ko04662 B cell receptor signaling pathway 10/224 88/7206 0.000372111390569 ko04514 Cell adhesion molecules (CAMs) 12/224 130/7206 0.000686120374019 ko05166 HTLV-I infection 20/224 292/7206 0.000798372564923 ko04080 Neuroactive ligand-receptor interaction 3/224 423/7206 0.00125622541878 ko05131 Shigellosis 8/224 82/7206 0.00379078833056 ko05169 Epstein-Barr virus infection 14/224 206/7206 0.00616230837857 ko05034 Alcoholism 1/224 238/7206 0.00719991400137 ko04610 Complement and coagulation cascades 7/224 79/7206 0.0111019065221 ko04666 Fc gamma R-mediated phagocytosis 9/224 122/7206 0.0134607801159 ko05016 Huntington's disease 1/224 215/7206 0.0151969402775 ko05143 African trypanosomiasis 4/224 32/7206 0.0165152710226 ko05134 Legionellosis 6/224 74/7206 0.0270074859797 ko04670 Leukocyte transendothelial migration 10/224 151/7206 0.0270581327975 ko04664 Fc epsilon RI signaling pathway 6/224 77/7206 0.0320407891746 ko05132 Salmonella infection 7/224 98/7206 0.0324362321999 ko05146 Amoebiasis 7/224 99/7206 0.0340192563101 ko04510 Focal adhesion 2/224 240/7206 0.0353714474503 ko05224 Breast cancer 1/224 174/7206 0.0452902665641 ko04310 Wnt signaling pathway 1/224 181/7206 0.0465409220308