ko pathway ratio_in_study ratio_in_pop p_value ko05164 Influenza A 34/240 167/7206 4.18119889569e-18 ko04060 Cytokine-cytokine receptor interaction 33/240 191/7206 2.32900112268e-15 ko04621 NOD-like receptor signaling pathway 30/240 157/7206 2.83097495245e-15 ko05340 Primary immunodeficiency 14/240 30/7206 1.2843267784e-13 ko04064 NF-kappa B signaling pathway 21/240 96/7206 3.33797450931e-12 ko05162 Measles 23/240 120/7206 5.59469793931e-12 ko05168 Herpes simplex infection 28/240 182/7206 6.89944639922e-12 ko04380 Osteoclast differentiation 24/240 134/7206 8.7177656639e-12 ko04620 Toll-like receptor signaling pathway 19/240 100/7206 4.97787273528e-10 ko04217 Necroptosis 25/240 178/7206 7.35859522101e-10 ko05145 Toxoplasmosis 21/240 126/7206 7.51624199436e-10 ko05140 Leishmaniasis 16/240 75/7206 2.06307606234e-09 ko05133 Pertussis 17/240 87/7206 2.68220722421e-09 ko04612 Antigen processing and presentation 16/240 77/7206 3.10789278466e-09 ko04659 Th17 cell differentiation 18/240 106/7206 9.51498325082e-09 ko04658 Th1 and Th2 cell differentiation 17/240 96/7206 1.29230563304e-08 ko05321 Inflammatory bowel disease (IBD) 13/240 56/7206 2.37237742176e-08 ko05152 Tuberculosis 23/240 187/7206 4.81099971746e-08 ko04622 RIG-I-like receptor signaling pathway 13/240 62/7206 8.72762206864e-08 ko05150 Staphylococcus aureus infection 10/240 36/7206 1.65238071311e-07 ko05161 Hepatitis B 21/240 173/7206 2.38355993393e-07 ko04650 Natural killer cell mediated cytotoxicity 15/240 97/7206 6.01885426215e-07 ko04660 T cell receptor signaling pathway 17/240 124/7206 6.21591889854e-07 ko05330 Allograft rejection 8/240 24/7206 6.24579168675e-07 ko04062 Chemokine signaling pathway 22/240 201/7206 7.52045518888e-07 ko05142 Chagas disease (American trypanosomiasis) 17/240 130/7206 1.22696002928e-06 ko05167 Kaposi's sarcoma-associated herpesvirus infection 21/240 191/7206 1.26143687307e-06 ko04630 Jak-STAT signaling pathway 17/240 132/7206 1.52473228615e-06 ko04672 Intestinal immune network for IgA production 9/240 37/7206 2.38891369185e-06 ko05160 Hepatitis C 18/240 153/7206 2.82961631446e-06 ko05320 Autoimmune thyroid disease 8/240 29/7206 3.1541068413e-06 ko05323 Rheumatoid arthritis 13/240 89/7206 6.63197292056e-06 ko05131 Shigellosis 12/240 82/7206 1.48126879765e-05 ko05332 Graft-versus-host disease 6/240 18/7206 1.70014654843e-05 ko04662 B cell receptor signaling pathway 12/240 88/7206 3.07598684902e-05 ko04623 Cytosolic DNA-sensing pathway 8/240 41/7206 4.96633837184e-05 ko04145 Phagosome 16/240 162/7206 9.05478518139e-05 ko04668 TNF signaling pathway 13/240 120/7206 0.000165132540943 ko05310 Asthma 5/240 17/7206 0.000175143732338 ko04640 Hematopoietic cell lineage 9/240 64/7206 0.000241324811482 ko04610 Complement and coagulation cascades 10/240 79/7206 0.000266021569077 ko05132 Salmonella infection 11/240 98/7206 0.000385573284492 ko05416 Viral myocarditis 8/240 55/7206 0.00042323824844 ko04940 Type I diabetes mellitus 6/240 32/7206 0.000560916215819 ko04657 IL-17 signaling pathway 10/240 87/7206 0.000585231252281 ko05144 Malaria 7/240 45/7206 0.000640611662624 ko05134 Legionellosis 9/240 74/7206 0.000725275162022 ko03050 Proteasome 7/240 54/7206 0.00193893460989 ko04666 Fc gamma R-mediated phagocytosis 11/240 122/7206 0.00239593735996 ko04210 Apoptosis 14/240 180/7206 0.00264307046765 ko04664 Fc epsilon RI signaling pathway 8/240 77/7206 0.00390310221984 ko04514 Cell adhesion molecules (CAMs) 11/240 130/7206 0.00393146147386 ko05166 HTLV-I infection 19/240 292/7206 0.00434960246862 ko05034 Alcoholism 1/240 238/7206 0.00500015579304 ko05146 Amoebiasis 9/240 99/7206 0.0055346690003 ko04080 Neuroactive ligand-receptor interaction 5/240 423/7206 0.00742294523269 ko05169 Epstein-Barr virus infection 14/240 206/7206 0.00954081145622 ko04670 Leukocyte transendothelial migration 11/240 151/7206 0.0175003883901 ko04390 Hippo signaling pathway 1/240 188/7206 0.0218931351246 ko04624 Toll and Imd signaling pathway 5/240 49/7206 0.0227548159678 ko04611 Platelet activation 11/240 163/7206 0.0236824911416 ko04917 Prolactin signaling pathway 7/240 87/7206 0.0254474784374 ko04510 Focal adhesion 2/240 240/7206 0.0256821140222 ko05120 Epithelial cell signaling in Helicobacter pylori infection 7/240 92/7206 0.0332295425458 ko01524 Platinum drug resistance 6/240 76/7206 0.0403989841471 ko05130 Pathogenic Escherichia coli infection 6/240 77/7206 0.0426448511702 ko04152 AMPK signaling pathway 1/240 161/7206 0.0452051168856 ko00140 Steroid hormone biosynthesis 4/240 41/7206 0.0464121494539