ko pathway ratio_in_study ratio_in_pop p_value ko05032 Morphine addiction 39/610 110/7206 1.39554829104e-15 ko05033 Nicotine addiction 27/610 56/7206 4.51625138282e-15 ko04080 Neuroactive ligand-receptor interaction 85/610 423/7206 8.55107777411e-15 ko04727 GABAergic synapse 36/610 110/7206 2.97532717561e-13 ko04724 Glutamatergic synapse 43/610 152/7206 4.28219439139e-13 ko04723 Retrograde endocannabinoid signaling 45/610 175/7206 4.79467463418e-12 ko04024 cAMP signaling pathway 58/610 279/7206 6.37593685432e-11 ko04713 Circadian entrainment 37/610 136/7206 6.886881562e-11 ko04725 Cholinergic synapse 38/610 160/7206 2.72093309406e-09 ko04721 Synaptic vesicle cycle 25/610 80/7206 4.02660793215e-09 ko04911 Insulin secretion 31/610 117/7206 5.03758994263e-09 ko04728 Dopaminergic synapse 40/610 185/7206 1.85222212094e-08 ko04020 Calcium signaling pathway 49/610 265/7206 1.11589353897e-07 ko04726 Serotonergic synapse 31/610 137/7206 2.62869891039e-07 ko04070 Phosphatidylinositol signaling system 25/610 112/7206 4.94565123034e-06 ko04921 Oxytocin signaling pathway 38/610 209/7206 5.78236506519e-06 ko04072 Phospholipase D signaling pathway 36/610 197/7206 1.08497924827e-05 ko04742 Taste transduction 16/610 61/7206 3.13191127173e-05 ko05322 Systemic lupus erythematosus 1/610 151/7206 4.11257174017e-05 ko03040 Spliceosome 1/610 145/7206 5.98451119739e-05 ko05030 Cocaine addiction 17/610 73/7206 9.22905214549e-05 ko04970 Salivary secretion 20/610 95/7206 0.000104560397653 ko04261 Adrenergic signaling in cardiomyocytes 34/610 205/7206 0.000110772131146 ko05031 Amphetamine addiction 19/610 91/7206 0.000173724982409 ko04514 Cell adhesion molecules (CAMs) 24/610 130/7206 0.000317158665223 ko04925 Aldosterone synthesis and secretion 20/610 105/7206 0.000517259207958 ko05203 Viral carcinogenesis 9/610 277/7206 0.000585801163678 ko04010 MAPK signaling pathway 45/610 321/7206 0.000643296489405 ko04022 cGMP-PKG signaling pathway 33/610 216/7206 0.000719542737563 ko04720 Long-term potentiation 18/610 99/7206 0.00159100454117 ko04744 Phototransduction 9/610 36/7206 0.00246916332354 ko03013 RNA transport 4/610 166/7206 0.00262532022271 ko04972 Pancreatic secretion 19/610 111/7206 0.00282047462074 ko04730 Long-term depression 15/610 78/7206 0.00294805959631 ko00562 Inositol phosphate metabolism 16/610 89/7206 0.00329160099145 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/610 14/7206 0.00448624335169 ko04930 Type II diabetes mellitus 11/610 54/7206 0.00483490457655 ko04144 Endocytosis 44/610 342/7206 0.00502936290507 ko04014 Ras signaling pathway 37/610 279/7206 0.00575692942602 ko04923 Regulation of lipolysis in adipocytes 14/610 77/7206 0.00576719017659 ko04141 Protein processing in endoplasmic reticulum 6/610 184/7206 0.00686088294679 ko04710 Circadian rhythm 9/610 43/7206 0.0086872932113 ko05168 Herpes simplex infection 6/610 182/7206 0.00955863776038 ko04915 Estrogen signaling pathway 20/610 131/7206 0.0100092297503 ko04540 Gap junction 19/610 128/7206 0.0149565652034 ko05164 Influenza A 6/610 167/7206 0.0166669104585 ko04966 Collecting duct acid secretion 6/610 26/7206 0.0190778246946 ko05110 Vibrio cholerae infection 11/610 63/7206 0.0192727142112 ko04612 Antigen processing and presentation 1/610 77/7206 0.0205376450359 ko04360 Axon guidance 30/610 233/7206 0.0220239207212 ko03015 mRNA surveillance pathway 2/610 93/7206 0.0228314806123 ko05205 Proteoglycans in cancer 13/610 271/7206 0.0255495352767 ko05231 Choline metabolism in cancer 19/610 134/7206 0.0263906704268 ko04961 Endocrine and other factor-regulated calcium reabsorption 10/610 59/7206 0.0302526502966 ko04964 Proximal tubule bicarbonate reclamation 6/610 29/7206 0.0317371686235 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 4/610 15/7206 0.0326644147294 ko04371 Apelin signaling pathway 23/610 177/7206 0.0387535017933 ko04120 Ubiquitin mediated proteolysis 5/610 138/7206 0.0427053078942 ko04971 Gastric acid secretion 14/610 98/7206 0.0440197081967 ko05131 Shigellosis 2/610 82/7206 0.0450980953238 ko04750 Inflammatory mediator regulation of TRP channels 17/610 122/7206 0.0462948987809 ko04924 Renin secretion 13/610 86/7206 0.0474114739865 ko00030 Pentose phosphate pathway 6/610 32/7206 0.0488874913904