ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	192/1138	423/7206	1.70001055783e-50
ko05033	Nicotine addiction	48/1138	56/7206	5.59876417842e-31
ko04724	Glutamatergic synapse	85/1138	152/7206	1.5009989596e-30
ko04721	Synaptic vesicle cycle	56/1138	80/7206	1.37848985161e-27
ko04713	Circadian entrainment	73/1138	136/7206	7.27603837094e-25
ko04727	GABAergic synapse	63/1138	110/7206	1.17935774209e-23
ko05032	Morphine addiction	63/1138	110/7206	1.17935774209e-23
ko04725	Cholinergic synapse	74/1138	160/7206	3.88224018329e-20
ko04728	Dopaminergic synapse	81/1138	185/7206	4.38648569981e-20
ko04723	Retrograde endocannabinoid signaling	74/1138	175/7206	2.13228042422e-17
ko04024	cAMP signaling pathway	99/1138	279/7206	1.64650896788e-16
ko04742	Taste transduction	38/1138	61/7206	1.85633967156e-16
ko04744	Phototransduction	27/1138	36/7206	3.86044104658e-15
ko04740	Olfactory transduction	42/1138	80/7206	2.34446587989e-14
ko04911	Insulin secretion	53/1138	117/7206	2.75736592973e-14
ko04726	Serotonergic synapse	58/1138	137/7206	6.46503199412e-14
ko04020	Calcium signaling pathway	88/1138	265/7206	8.43272786998e-13
ko04921	Oxytocin signaling pathway	73/1138	209/7206	5.93163749229e-12
ko05031	Amphetamine addiction	42/1138	91/7206	6.40840146812e-12
ko04720	Long-term potentiation	43/1138	99/7206	4.33568507637e-11
ko04261	Adrenergic signaling in cardiomyocytes	68/1138	205/7206	3.55873060961e-10
ko04970	Salivary secretion	39/1138	95/7206	2.58081875914e-09
ko03040	Spliceosome	2/1138	145/7206	1.0703650497e-08
ko05203	Viral carcinogenesis	14/1138	277/7206	2.9499312399e-08
ko05168	Herpes simplex infection	6/1138	182/7206	8.28612737196e-08
ko05164	Influenza A	5/1138	167/7206	1.35029980798e-07
ko04966	Collecting duct acid secretion	16/1138	26/7206	1.49092969521e-07
ko05030	Cocaine addiction	30/1138	73/7206	1.74180072218e-07
ko04360	Axon guidance	68/1138	233/7206	1.97453910194e-07
ko04120	Ubiquitin mediated proteolysis	3/1138	138/7206	2.06446995898e-07
ko04925	Aldosterone synthesis and secretion	38/1138	105/7206	2.38724573113e-07
ko04971	Gastric acid secretion	36/1138	98/7206	3.49533199798e-07
ko04060	Cytokine-cytokine receptor interaction	8/1138	191/7206	5.44869855978e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1138	74/7206	9.20881741996e-07
ko04924	Renin secretion	32/1138	86/7206	1.34407848742e-06
ko03013	RNA transport	7/1138	166/7206	4.15732786765e-06
ko04022	cGMP-PKG signaling pathway	59/1138	216/7206	1.07330799852e-05
ko04141	Protein processing in endoplasmic reticulum	10/1138	184/7206	2.10215525785e-05
ko04745	Phototransduction - fly	17/1138	38/7206	2.20380668099e-05
ko04540	Gap junction	39/1138	128/7206	2.38314775445e-05
ko04260	Cardiac muscle contraction	32/1138	98/7206	3.20826305848e-05
ko05169	Epstein-Barr virus infection	13/1138	206/7206	4.04810929104e-05
ko04514	Cell adhesion molecules (CAMs)	39/1138	130/7206	4.41229924902e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1138	59/7206	4.69807015575e-05
ko04621	NOD-like receptor signaling pathway	8/1138	157/7206	5.3053484805e-05
ko05110	Vibrio cholerae infection	23/1138	63/7206	6.57534952836e-05
ko05322	Systemic lupus erythematosus	8/1138	151/7206	0.000102923779347
ko04010	MAPK signaling pathway	77/1138	321/7206	0.000112297905528
ko04730	Long-term depression	26/1138	78/7206	0.000114404754948
ko05162	Measles	5/1138	120/7206	0.000115641457906
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1138	79/7206	0.00013613309124
ko03008	Ribosome biogenesis in eukaryotes	2/1138	79/7206	0.000265946336371
ko04146	Peroxisome	3/1138	89/7206	0.000350033229145
ko05205	Proteoglycans in cancer	23/1138	271/7206	0.000461501826502
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1138	14/7206	0.000464059720008
ko04014	Ras signaling pathway	66/1138	279/7206	0.000550888235511
ko04064	NF-kappa B signaling pathway	4/1138	96/7206	0.000599700677245
ko04915	Estrogen signaling pathway	36/1138	131/7206	0.000603262011185
ko05140	Leishmaniasis	2/1138	75/7206	0.000612596551738
ko05161	Hepatitis B	12/1138	173/7206	0.000655773300175
ko04110	Cell cycle	9/1138	145/7206	0.000740110894365
ko04626	Plant-pathogen interaction	9/1138	18/7206	0.000742244585192
ko04972	Pancreatic secretion	31/1138	111/7206	0.000939276828537
ko00480	Glutathione metabolism	1/1138	55/7206	0.00133828829245
ko00240	Pyrimidine metabolism	6/1138	110/7206	0.00138552273544
ko05414	Dilated cardiomyopathy	31/1138	112/7206	0.00147488741017
ko04750	Inflammatory mediator regulation of TRP channels	33/1138	122/7206	0.00151867781424
ko04640	Hematopoietic cell lineage	2/1138	64/7206	0.00280463616489
ko04976	Bile secretion	23/1138	80/7206	0.00298358254522
ko04964	Proximal tubule bicarbonate reclamation	11/1138	29/7206	0.00320555521202
ko04214	Apoptosis - fly	3/1138	72/7206	0.00322126745452
ko00590	Arachidonic acid metabolism	1/1138	52/7206	0.00324801305385
ko03018	RNA degradation	4/1138	84/7206	0.00366709396295
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1138	182/7206	0.0037100778988
ko04350	TGF-beta signaling pathway	6/1138	103/7206	0.00380294946096
ko05166	HTLV-I infection	29/1138	292/7206	0.00403618280354
ko01200	Carbon metabolism	9/1138	128/7206	0.00455574322079
ko04070	Phosphatidylinositol signaling system	29/1138	112/7206	0.00562584683953
ko05144	Malaria	1/1138	45/7206	0.00680284221006
ko00071	Fatty acid degradation	1/1138	45/7206	0.00680284221006
ko03420	Nucleotide excision repair	1/1138	46/7206	0.00697567084246
ko05321	Inflammatory bowel disease (IBD)	2/1138	56/7206	0.00872287884185
ko05120	Epithelial cell signaling in Helicobacter pylori infection	24/1138	92/7206	0.00936234439928
ko04072	Phospholipase D signaling pathway	45/1138	197/7206	0.00960844325172
ko04115	p53 signaling pathway	4/1138	74/7206	0.00983492504589
ko00983	Drug metabolism - other enzymes	1/1138	42/7206	0.010167690342
ko04916	Melanogenesis	34/1138	142/7206	0.0102018825947
ko01524	Platinum drug resistance	4/1138	76/7206	0.0102648525757
ko03022	Basal transcription factors	1/1138	44/7206	0.0107543792386
ko04923	Regulation of lipolysis in adipocytes	21/1138	77/7206	0.0107697625783
ko04668	TNF signaling pathway	9/1138	120/7206	0.0109235564465
ko04620	Toll-like receptor signaling pathway	7/1138	100/7206	0.0124096829883
ko00280	Valine, leucine and isoleucine degradation	2/1138	54/7206	0.0130393558276
ko05145	Toxoplasmosis	10/1138	126/7206	0.0131373556445
ko04622	RIG-I-like receptor signaling pathway	3/1138	62/7206	0.0134647768635
ko00600	Sphingolipid metabolism	3/1138	63/7206	0.0137279487378
ko00310	Lysine degradation	4/1138	73/7206	0.0141965196722
ko05418	Fluid shear stress and atherosclerosis	16/1138	173/7206	0.0149468005717
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1138	40/7206	0.0152384544426
ko04657	IL-17 signaling pathway	6/1138	87/7206	0.0177849625966
ko05034	Alcoholism	51/1138	238/7206	0.0185727118527
ko00330	Arginine and proline metabolism	3/1138	61/7206	0.019933903588
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1138	15/7206	0.0212632608461
ko00982	Drug metabolism - cytochrome P450	1/1138	37/7206	0.0226240063357
ko00630	Glyoxylate and dicarboxylate metabolism	1/1138	38/7206	0.0230665739414
ko04912	GnRH signaling pathway	29/1138	122/7206	0.0231921530751
ko00270	Cysteine and methionine metabolism	2/1138	47/7206	0.0259474409034
ko04612	Antigen processing and presentation	5/1138	77/7206	0.0262024540108
ko04371	Apelin signaling pathway	39/1138	177/7206	0.0277645797658
ko04140	Autophagy - animal	16/1138	164/7206	0.0301486782275
ko04630	Jak-STAT signaling pathway	12/1138	132/7206	0.0301666156491
ko05131	Shigellosis	6/1138	82/7206	0.0323966843296
ko05212	Pancreatic cancer	6/1138	83/7206	0.0327027926142
ko05146	Amoebiasis	8/1138	99/7206	0.0362152648374
ko05206	MicroRNAs in cancer	18/1138	177/7206	0.036729441874
ko04722	Neurotrophin signaling pathway	35/1138	160/7206	0.0371535177848
ko05222	Small cell lung cancer	7/1138	89/7206	0.0397002966099
ko04962	Vasopressin-regulated water reabsorption	15/1138	58/7206	0.0449874328253
ko03320	PPAR signaling pathway	5/1138	69/7206	0.0472114730272
ko04210	Apoptosis	19/1138	180/7206	0.0494890770713