ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	183/1113	423/7206	8.90304291001e-46
ko04724	Glutamatergic synapse	83/1113	152/7206	1.45675180334e-29
ko05033	Nicotine addiction	45/1113	56/7206	3.83319097125e-27
ko05032	Morphine addiction	66/1113	110/7206	6.15341434693e-27
ko04727	GABAergic synapse	62/1113	110/7206	2.56664650948e-23
ko04728	Dopaminergic synapse	80/1113	185/7206	4.66374225828e-20
ko04713	Circadian entrainment	64/1113	136/7206	1.49369660224e-18
ko04725	Cholinergic synapse	70/1113	160/7206	5.14657460527e-18
ko04723	Retrograde endocannabinoid signaling	74/1113	175/7206	5.87346477532e-18
ko04024	cAMP signaling pathway	100/1113	279/7206	1.21189106411e-17
ko04721	Synaptic vesicle cycle	45/1113	80/7206	3.3701847632e-17
ko04742	Taste transduction	36/1113	61/7206	6.53485257907e-15
ko04726	Serotonergic synapse	56/1113	137/7206	3.99283084979e-13
ko04911	Insulin secretion	48/1113	117/7206	1.68254733642e-11
ko04020	Calcium signaling pathway	83/1113	265/7206	3.26831035668e-11
ko04360	Axon guidance	75/1113	233/7206	7.2754166996e-11
ko04261	Adrenergic signaling in cardiomyocytes	67/1113	205/7206	4.05510728885e-10
ko03040	Spliceosome	1/1113	145/7206	8.50375474722e-10
ko04921	Oxytocin signaling pathway	66/1113	209/7206	2.59663853549e-09
ko04744	Phototransduction	20/1113	36/7206	3.10303222257e-08
ko05030	Cocaine addiction	30/1113	73/7206	1.04972188955e-07
ko03013	RNA transport	5/1113	166/7206	3.12350868948e-07
ko05203	Viral carcinogenesis	16/1113	277/7206	6.58860029904e-07
ko04970	Salivary secretion	34/1113	95/7206	8.82703765998e-07
ko05322	Systemic lupus erythematosus	5/1113	151/7206	2.02966113389e-06
ko05031	Amphetamine addiction	32/1113	91/7206	2.75234140049e-06
ko05168	Herpes simplex infection	8/1113	182/7206	3.40458545352e-06
ko04010	MAPK signaling pathway	81/1113	321/7206	3.70225533063e-06
ko04720	Long-term potentiation	33/1113	99/7206	7.803901598e-06
ko04514	Cell adhesion molecules (CAMs)	40/1113	130/7206	1.1442506123e-05
ko04060	Cytokine-cytokine receptor interaction	10/1113	191/7206	1.5624038631e-05
ko05164	Influenza A	8/1113	167/7206	1.93811009295e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1113	74/7206	2.61054472366e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1113	79/7206	2.92494067077e-05
ko04141	Protein processing in endoplasmic reticulum	10/1113	184/7206	3.004180542e-05
ko04022	cGMP-PKG signaling pathway	57/1113	216/7206	3.17944035251e-05
ko04971	Gastric acid secretion	31/1113	98/7206	5.27434926236e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1113	79/7206	5.29365593113e-05
ko04120	Ubiquitin mediated proteolysis	6/1113	138/7206	6.58381110835e-05
ko05205	Proteoglycans in cancer	20/1113	271/7206	7.1461379729e-05
ko00240	Pyrimidine metabolism	4/1113	110/7206	0.000146966465312
ko04972	Pancreatic secretion	33/1113	111/7206	0.000154697695914
ko04925	Aldosterone synthesis and secretion	31/1113	105/7206	0.000200911418084
ko04540	Gap junction	36/1113	128/7206	0.000275328051462
ko05414	Dilated cardiomyopathy	32/1113	112/7206	0.000320920858967
ko04070	Phosphatidylinositol signaling system	32/1113	112/7206	0.000320920858967
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1113	59/7206	0.000384645579285
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1113	14/7206	0.000396623195006
ko05140	Leishmaniasis	2/1113	75/7206	0.000593708268293
ko04730	Long-term depression	24/1113	78/7206	0.000695622685043
ko04072	Phospholipase D signaling pathway	48/1113	197/7206	0.000898010778167
ko04014	Ras signaling pathway	64/1113	279/7206	0.000917095325993
ko04966	Collecting duct acid secretion	11/1113	26/7206	0.000932045114524
ko04260	Cardiac muscle contraction	28/1113	98/7206	0.00097959155371
ko04924	Renin secretion	25/1113	86/7206	0.00131085616346
ko04146	Peroxisome	4/1113	89/7206	0.00178223988267
ko01200	Carbon metabolism	8/1113	128/7206	0.00193434304452
ko00480	Glutathione metabolism	1/1113	55/7206	0.00210905300778
ko04612	Antigen processing and presentation	3/1113	77/7206	0.00227913038625
ko05169	Epstein-Barr virus infection	17/1113	206/7206	0.00237321711508
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/1113	182/7206	0.00241212048636
ko04640	Hematopoietic cell lineage	2/1113	64/7206	0.00277507052289
ko04391	Hippo signaling pathway - fly	25/1113	90/7206	0.00284613613615
ko00590	Arachidonic acid metabolism	1/1113	52/7206	0.0031234948779
ko04915	Estrogen signaling pathway	33/1113	131/7206	0.00320864594383
ko03018	RNA degradation	4/1113	84/7206	0.00358035315653
ko00330	Arginine and proline metabolism	2/1113	61/7206	0.00406396704244
ko04740	Olfactory transduction	22/1113	80/7206	0.00478909305729
ko04621	NOD-like receptor signaling pathway	12/1113	157/7206	0.00493500484252
ko05161	Hepatitis B	14/1113	173/7206	0.00535859522526
ko04923	Regulation of lipolysis in adipocytes	21/1113	77/7206	0.00659501131212
ko03420	Nucleotide excision repair	1/1113	46/7206	0.00691085506841
ko04015	Rap1 signaling pathway	59/1113	278/7206	0.00855694385841
ko04658	Th1 and Th2 cell differentiation	6/1113	96/7206	0.00980270771774
ko04064	NF-kappa B signaling pathway	6/1113	96/7206	0.00980270771774
ko05133	Pertussis	5/1113	87/7206	0.0102275101171
ko03022	Basal transcription factors	1/1113	44/7206	0.0104547702127
ko05144	Malaria	1/1113	45/7206	0.0109234671494
ko04371	Apelin signaling pathway	40/1113	177/7206	0.0110880719666
ko04140	Autophagy - animal	14/1113	164/7206	0.0115748210653
ko04976	Bile secretion	21/1113	80/7206	0.0118451709693
ko00280	Valine, leucine and isoleucine degradation	2/1113	54/7206	0.0126596959244
ko00561	Glycerolipid metabolism	3/1113	63/7206	0.0136196178436
ko05131	Shigellosis	5/1113	82/7206	0.0137739709722
ko04110	Cell cycle	12/1113	145/7206	0.0142847391699
ko05162	Measles	9/1113	120/7206	0.0147081993288
ko04217	Necroptosis	16/1113	178/7206	0.0152274676543
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1113	40/7206	0.0154069058192
ko00983	Drug metabolism - other enzymes	1/1113	42/7206	0.0159925260168
ko05145	Toxoplasmosis	10/1113	126/7206	0.0174615839173
ko00380	Tryptophan metabolism	2/1113	50/7206	0.0181683736236
ko04630	Jak-STAT signaling pathway	11/1113	132/7206	0.0204762688637
ko05110	Vibrio cholerae infection	17/1113	63/7206	0.0207690287104
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1113	100/7206	0.0246409970898
ko05219	Bladder cancer	2/1113	48/7206	0.0262284360107
ko04750	Inflammatory mediator regulation of TRP channels	28/1113	122/7206	0.0305600509551
ko04964	Proximal tubule bicarbonate reclamation	9/1113	29/7206	0.0339715747621
ko00020	Citrate cycle (TCA cycle)	1/1113	35/7206	0.0339803882999
ko04115	p53 signaling pathway	5/1113	74/7206	0.0351278439489
ko00982	Drug metabolism - cytochrome P450	1/1113	37/7206	0.035904821945
ko04071	Sphingolipid signaling pathway	35/1113	162/7206	0.0359252894756
ko04620	Toll-like receptor signaling pathway	8/1113	100/7206	0.0362718171031
ko04062	Chemokine signaling pathway	42/1113	201/7206	0.0370512853718
ko00071	Fatty acid degradation	2/1113	45/7206	0.0376523378155
ko04930	Type II diabetes mellitus	14/1113	54/7206	0.0381574651633
ko00562	Inositol phosphate metabolism	21/1113	89/7206	0.0384036753911
ko05321	Inflammatory bowel disease (IBD)	3/1113	56/7206	0.0388586912484
ko04138	Autophagy - yeast	6/1113	81/7206	0.0438246686272
ko00515	Mannose type O-glycan biosynthesis	8/1113	25/7206	0.0446029173171
ko04144	Endocytosis	66/1113	342/7206	0.0462692575972
ko04214	Apoptosis - fly	5/1113	72/7206	0.0478087226432
ko00310	Lysine degradation	5/1113	73/7206	0.0486246578999