ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	171/1045	423/7206	8.5814838811e-42
ko04724	Glutamatergic synapse	79/1045	152/7206	3.67563262364e-28
ko05033	Nicotine addiction	43/1045	56/7206	1.15193382359e-25
ko04721	Synaptic vesicle cycle	51/1045	80/7206	4.38122610755e-24
ko05032	Morphine addiction	59/1045	110/7206	3.41915041056e-22
ko04727	GABAergic synapse	56/1045	110/7206	1.07940294006e-19
ko04713	Circadian entrainment	63/1045	136/7206	2.8076536403e-19
ko04728	Dopaminergic synapse	76/1045	185/7206	3.5122800871e-19
ko04725	Cholinergic synapse	67/1045	160/7206	1.48939839447e-17
ko04723	Retrograde endocannabinoid signaling	69/1045	175/7206	2.17700353899e-16
ko04742	Taste transduction	36/1045	61/7206	8.50608876702e-16
ko04024	cAMP signaling pathway	90/1045	279/7206	1.42980087695e-14
ko04921	Oxytocin signaling pathway	71/1045	209/7206	7.06696511385e-13
ko04911	Insulin secretion	48/1045	117/7206	1.6085526984e-12
ko04726	Serotonergic synapse	53/1045	137/7206	1.777840162e-12
ko04020	Calcium signaling pathway	79/1045	265/7206	6.13388377914e-11
ko04261	Adrenergic signaling in cardiomyocytes	62/1045	205/7206	4.27682315987e-09
ko03040	Spliceosome	1/1045	145/7206	5.78519314243e-09
ko04744	Phototransduction	20/1045	36/7206	1.02739078468e-08
ko04720	Long-term potentiation	37/1045	99/7206	1.26266700148e-08
ko05031	Amphetamine addiction	35/1045	91/7206	1.31855915252e-08
ko05203	Viral carcinogenesis	12/1045	277/7206	4.2682136415e-08
ko05168	Herpes simplex infection	5/1045	182/7206	1.63554296506e-07
ko04970	Salivary secretion	34/1045	95/7206	1.68404633265e-07
ko05164	Influenza A	4/1045	167/7206	1.69131180522e-07
ko04740	Olfactory transduction	30/1045	80/7206	2.7743336728e-07
ko04360	Axon guidance	63/1045	233/7206	3.65432655279e-07
ko04971	Gastric acid secretion	34/1045	98/7206	5.8743806048e-07
ko03013	RNA transport	5/1045	166/7206	1.07309007415e-06
ko04060	Cytokine-cytokine receptor interaction	7/1045	191/7206	1.12349284707e-06
ko05030	Cocaine addiction	27/1045	73/7206	1.49747053775e-06
ko04966	Collecting duct acid secretion	14/1045	26/7206	2.92679276325e-06
ko04925	Aldosterone synthesis and secretion	34/1045	105/7206	3.62747858536e-06
ko04010	MAPK signaling pathway	77/1045	321/7206	4.49007953079e-06
ko05322	Systemic lupus erythematosus	5/1045	151/7206	1.03256324312e-05
ko04514	Cell adhesion molecules (CAMs)	38/1045	130/7206	1.24251525969e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	25/1045	74/7206	3.15582990823e-05
ko04120	Ubiquitin mediated proteolysis	5/1045	138/7206	4.28417926951e-05
ko04540	Gap junction	36/1045	128/7206	6.10421064843e-05
ko04730	Long-term depression	25/1045	78/7206	6.69839423467e-05
ko04022	cGMP-PKG signaling pathway	53/1045	216/7206	7.34801741273e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1045	79/7206	8.28593158626e-05
ko04610	Complement and coagulation cascades	1/1045	79/7206	0.000136006340836
ko03008	Ribosome biogenesis in eukaryotes	1/1045	79/7206	0.000136006340836
ko04924	Renin secretion	26/1045	86/7206	0.00015436071279
ko04972	Pancreatic secretion	31/1045	111/7206	0.00019608486005
ko04621	NOD-like receptor signaling pathway	8/1045	157/7206	0.000219996222741
ko04014	Ras signaling pathway	63/1045	279/7206	0.000243209664961
ko04964	Proximal tubule bicarbonate reclamation	12/1045	29/7206	0.000386135394773
ko04141	Protein processing in endoplasmic reticulum	11/1045	184/7206	0.000408630614962
ko05110	Vibrio cholerae infection	20/1045	63/7206	0.000431880554269
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1045	59/7206	0.000527087406424
ko04745	Phototransduction - fly	14/1045	38/7206	0.000534440213598
ko04260	Cardiac muscle contraction	27/1045	98/7206	0.00071546090621
ko05205	Proteoglycans in cancer	21/1045	271/7206	0.000780281323121
ko05169	Epstein-Barr virus infection	14/1045	206/7206	0.000839422098199
ko04640	Hematopoietic cell lineage	1/1045	64/7206	0.000986091498217
ko04976	Bile secretion	23/1045	80/7206	0.00107166731332
ko05161	Hepatitis B	11/1045	173/7206	0.00137243770983
ko05140	Leishmaniasis	2/1045	75/7206	0.00138859947897
ko05162	Measles	6/1045	120/7206	0.00149981580717
ko04371	Apelin signaling pathway	41/1045	177/7206	0.00164580741513
ko04064	NF-kappa B signaling pathway	4/1045	96/7206	0.00189181036431
ko04626	Plant-pathogen interaction	8/1045	18/7206	0.00215070143167
ko04915	Estrogen signaling pathway	32/1045	131/7206	0.00238782840605
ko04750	Inflammatory mediator regulation of TRP channels	30/1045	122/7206	0.00266197989777
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1045	182/7206	0.00272022121313
ko05414	Dilated cardiomyopathy	28/1045	112/7206	0.00274942701458
ko00480	Glutathione metabolism	1/1045	55/7206	0.00325514899051
ko04146	Peroxisome	4/1045	89/7206	0.00375326005232
ko00240	Pyrimidine metabolism	6/1045	110/7206	0.00393241566856
ko00590	Arachidonic acid metabolism	1/1045	52/7206	0.00484587067904
ko04612	Antigen processing and presentation	3/1045	77/7206	0.00498487820506
ko04110	Cell cycle	10/1045	145/7206	0.0059728284244
ko00561	Glycerolipid metabolism	2/1045	63/7206	0.00622399633251
ko00310	Lysine degradation	3/1045	73/7206	0.0070079033366
ko00330	Arginine and proline metabolism	2/1045	61/7206	0.00923367033794
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1045	14/7206	0.00970767632782
ko04072	Phospholipase D signaling pathway	42/1045	197/7206	0.00988081967031
ko04214	Apoptosis - fly	3/1045	72/7206	0.0103466884444
ko03420	Nucleotide excision repair	1/1045	46/7206	0.0107202614062
ko04668	TNF signaling pathway	8/1045	120/7206	0.0123015936212
ko03022	Basal transcription factors	1/1045	44/7206	0.016146598401
ko05144	Malaria	1/1045	45/7206	0.0167876297348
ko00071	Fatty acid degradation	1/1045	45/7206	0.0167876297348
ko04217	Necroptosis	15/1045	178/7206	0.0174802722886
ko00280	Valine, leucine and isoleucine degradation	2/1045	54/7206	0.0187889056906
ko04115	p53 signaling pathway	4/1045	74/7206	0.020061925492
ko01524	Platinum drug resistance	4/1045	76/7206	0.0203896892168
ko05410	Hypertrophic cardiomyopathy (HCM)	23/1045	100/7206	0.0212072687773
ko05166	HTLV-I infection	29/1045	292/7206	0.0218775948357
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1045	40/7206	0.0236125506578
ko04630	Jak-STAT signaling pathway	10/1045	132/7206	0.0237560110898
ko05131	Shigellosis	5/1045	82/7206	0.0265983138287
ko03018	RNA degradation	5/1045	84/7206	0.0273942475948
ko04622	RIG-I-like receptor signaling pathway	3/1045	62/7206	0.028198701426
ko04070	Phosphatidylinositol signaling system	25/1045	112/7206	0.0291434973863
ko01200	Carbon metabolism	10/1045	128/7206	0.0304631914436
ko04620	Toll-like receptor signaling pathway	7/1045	100/7206	0.0310737210563
ko00982	Drug metabolism - cytochrome P450	1/1045	37/7206	0.0349556901607
ko05120	Epithelial cell signaling in Helicobacter pylori infection	21/1045	92/7206	0.0351723994475
ko03410	Base excision repair	1/1045	38/7206	0.0351943851663
ko04015	Rap1 signaling pathway	53/1045	278/7206	0.0365491877979
ko03320	PPAR signaling pathway	4/1045	69/7206	0.038182895607
ko05219	Bladder cancer	2/1045	48/7206	0.0386876145357
ko05145	Toxoplasmosis	10/1045	126/7206	0.0398595413574
ko00380	Tryptophan metabolism	2/1045	50/7206	0.0404344093497
ko04658	Th1 and Th2 cell differentiation	7/1045	96/7206	0.0410111093294
ko04657	IL-17 signaling pathway	6/1045	87/7206	0.0451428122922
ko05133	Pertussis	6/1045	87/7206	0.0451428122922
ko04391	Hippo signaling pathway - fly	20/1045	90/7206	0.0484139331374