ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 126/588 423/7206 5.82801995709e-42 ko05033 Nicotine addiction 37/588 56/7206 1.80215024267e-27 ko04724 Glutamatergic synapse 58/588 152/7206 2.08126522384e-25 ko04713 Circadian entrainment 45/588 136/7206 4.26789549655e-17 ko04020 Calcium signaling pathway 65/588 265/7206 1.19479918978e-16 ko04024 cAMP signaling pathway 65/588 279/7206 1.85403403424e-15 ko04727 GABAergic synapse 37/588 110/7206 1.61852216629e-14 ko05031 Amphetamine addiction 30/588 91/7206 9.47577810135e-12 ko04723 Retrograde endocannabinoid signaling 43/588 175/7206 2.18188282691e-11 ko04728 Dopaminergic synapse 44/588 185/7206 4.07897512031e-11 ko05032 Morphine addiction 32/588 110/7206 8.04692040598e-11 ko04720 Long-term potentiation 30/588 99/7206 1.03614674262e-10 ko04911 Insulin secretion 32/588 117/7206 4.67026301008e-10 ko04742 Taste transduction 21/588 61/7206 5.34019387977e-09 ko05030 Cocaine addiction 23/588 73/7206 7.05783401186e-09 ko04261 Adrenergic signaling in cardiomyocytes 42/588 205/7206 1.45204701716e-08 ko04921 Oxytocin signaling pathway 42/588 209/7206 4.05183668285e-08 ko04970 Salivary secretion 24/588 95/7206 3.68955274738e-07 ko04725 Cholinergic synapse 33/588 160/7206 4.53637457937e-07 ko04726 Serotonergic synapse 29/588 137/7206 1.29970234618e-06 ko05203 Viral carcinogenesis 4/588 277/7206 1.56082248981e-06 ko04010 MAPK signaling pathway 50/588 321/7206 5.70354037184e-06 ko04925 Aldosterone synthesis and secretion 23/588 105/7206 8.96688724715e-06 ko04721 Synaptic vesicle cycle 19/588 80/7206 1.6006090575e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 18/588 74/7206 1.88144167462e-05 ko04730 Long-term depression 18/588 78/7206 4.03869645809e-05 ko04924 Renin secretion 19/588 86/7206 4.73638497602e-05 ko04072 Phospholipase D signaling pathway 33/588 197/7206 5.58911163736e-05 ko04022 cGMP-PKG signaling pathway 35/588 216/7206 7.01604998014e-05 ko04971 Gastric acid secretion 20/588 98/7206 9.91555007992e-05 ko05164 Influenza A 2/588 167/7206 0.000145184556425 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 17/588 79/7206 0.000165843839214 ko04972 Pancreatic secretion 21/588 111/7206 0.000280642971808 ko03010 Ribosome 1/588 129/7206 0.000458890486133 ko04740 Olfactory transduction 16/588 80/7206 0.000612545194534 ko04110 Cell cycle 2/588 145/7206 0.000632674131336 ko04070 Phosphatidylinositol signaling system 20/588 112/7206 0.000707001866899 ko04514 Cell adhesion molecules (CAMs) 22/588 130/7206 0.000930496166208 ko05169 Epstein-Barr virus infection 5/588 206/7206 0.00105455533208 ko04260 Cardiac muscle contraction 18/588 98/7206 0.00106065238259 ko05168 Herpes simplex infection 4/588 182/7206 0.00135156401703 ko04932 Non-alcoholic fatty liver disease (NAFLD) 4/588 182/7206 0.00135156401703 ko04540 Gap junction 21/588 128/7206 0.00168708609296 ko05414 Dilated cardiomyopathy 19/588 112/7206 0.00238035865157 ko05200 Pathways in cancer 23/588 492/7206 0.00269064427119 ko04745 Phototransduction - fly 9/588 38/7206 0.00286172203034 ko04350 TGF-beta signaling pathway 1/588 103/7206 0.00302114887795 ko04141 Protein processing in endoplasmic reticulum 5/588 184/7206 0.00375718832918 ko05162 Measles 2/588 120/7206 0.00391139334435 ko05205 Proteoglycans in cancer 10/588 271/7206 0.00437376219965 ko04750 Inflammatory mediator regulation of TRP channels 19/588 122/7206 0.00647368476728 ko04060 Cytokine-cytokine receptor interaction 6/588 191/7206 0.00692999679696 ko04621 NOD-like receptor signaling pathway 4/588 157/7206 0.00711088552609 ko04964 Proximal tubule bicarbonate reclamation 7/588 29/7206 0.00741721593945 ko00240 Pyrimidine metabolism 2/588 110/7206 0.00798761186445 ko04657 IL-17 signaling pathway 1/588 87/7206 0.00929336324331 ko05322 Systemic lupus erythematosus 4/588 151/7206 0.00965733617352 ko04550 Signaling pathways regulating pluripotency of stem cells 5/588 165/7206 0.0133257258607 ko03018 RNA degradation 1/588 84/7206 0.0139633437143 ko04612 Antigen processing and presentation 1/588 77/7206 0.0197066757942 ko04510 Focal adhesion 10/588 240/7206 0.0217519047996 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/588 14/7206 0.0226842886022 ko04658 Th1 and Th2 cell differentiation 2/588 96/7206 0.0229421064268 ko05161 Hepatitis B 6/588 173/7206 0.0230789714798 ko05410 Hypertrophic cardiomyopathy (HCM) 15/588 100/7206 0.0245229859895 ko04214 Apoptosis - fly 1/588 72/7206 0.0286216319272 ko03013 RNA transport 6/588 166/7206 0.0300798179823 ko05140 Leishmaniasis 1/588 75/7206 0.0301244843482 ko00250 Alanine, aspartate and glutamate metabolism 7/588 38/7206 0.0317577339293 ko00562 Inositol phosphate metabolism 13/588 89/7206 0.0320328825546 ko00190 Oxidative phosphorylation 4/588 127/7206 0.0329118576934 ko00471 D-Glutamine and D-glutamate metabolism 2/588 4/7206 0.0356932607849 ko02010 ABC transporters 7/588 39/7206 0.0360869341084 ko04976 Bile secretion 12/588 80/7206 0.0365830389501 ko04930 Type II diabetes mellitus 9/588 54/7206 0.0390850634984 ko04145 Phagosome 6/588 162/7206 0.0402699759404 ko04978 Mineral absorption 7/588 40/7206 0.0407885014047 ko03320 PPAR signaling pathway 1/588 69/7206 0.0426069683169 ko05167 Kaposi's sarcoma-associated herpesvirus infection 8/588 191/7206 0.0433695851839 ko04015 Rap1 signaling pathway 32/588 278/7206 0.0437323839252 ko05145 Toxoplasmosis 4/588 126/7206 0.0461620867987 ko04146 Peroxisome 2/588 89/7206 0.0475106338801 ko00515 Mannose type O-glycan biosynthesis 5/588 25/7206 0.048195773834