ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 35/340 191/7206 2.12445830334e-12 ko04610 Complement and coagulation cascades 17/340 79/7206 1.05150223738e-07 ko04380 Osteoclast differentiation 22/340 134/7206 2.40070992366e-07 ko04064 NF-kappa B signaling pathway 18/340 96/7206 4.03531814144e-07 ko04621 NOD-like receptor signaling pathway 22/340 157/7206 3.82171862164e-06 ko05150 Staphylococcus aureus infection 10/340 36/7206 4.05899839984e-06 ko00120 Primary bile acid biosynthesis 7/340 20/7206 2.22700138108e-05 ko05164 Influenza A 21/340 167/7206 3.44578585534e-05 ko04650 Natural killer cell mediated cytotoxicity 15/340 97/7206 4.25917339648e-05 ko04630 Jak-STAT signaling pathway 18/340 132/7206 4.26747879449e-05 ko00950 Isoquinoline alkaloid biosynthesis 5/340 10/7206 4.70349917463e-05 ko04670 Leukocyte transendothelial migration 19/340 151/7206 8.07453435906e-05 ko05162 Measles 16/340 120/7206 0.000148656956054 ko04668 TNF signaling pathway 16/340 120/7206 0.000148656956054 ko05144 Malaria 9/340 45/7206 0.000204433104096 ko04660 T cell receptor signaling pathway 16/340 124/7206 0.000219109229733 ko04662 B cell receptor signaling pathway 13/340 88/7206 0.000221112366932 ko04672 Intestinal immune network for IgA production 8/340 37/7206 0.000262262735316 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 3/340 4/7206 0.000402013253818 ko05140 Leishmaniasis 11/340 75/7206 0.000711823118832 ko00350 Tyrosine metabolism 7/340 33/7206 0.00072174689936 ko04620 Toll-like receptor signaling pathway 13/340 100/7206 0.000785710056852 ko00360 Phenylalanine metabolism 5/340 17/7206 0.000877850162425 ko05323 Rheumatoid arthritis 12/340 89/7206 0.000894578019698 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 3/340 5/7206 0.000969848606563 ko05321 Inflammatory bowel disease (IBD) 9/340 56/7206 0.00110593094396 ko00592 alpha-Linolenic acid metabolism 5/340 19/7206 0.00152584387531 ko04658 Th1 and Th2 cell differentiation 12/340 96/7206 0.00175119808737 ko04217 Necroptosis 18/340 178/7206 0.0019314428547 ko05340 Primary immunodeficiency 6/340 30/7206 0.00239339841856 ko00590 Arachidonic acid metabolism 8/340 52/7206 0.00275902720658 ko04723 Retrograde endocannabinoid signaling 1/340 175/7206 0.0033440119141 ko05168 Herpes simplex infection 18/340 182/7206 0.00364782540211 ko04611 Platelet activation 16/340 163/7206 0.00455101784683 ko05131 Shigellosis 10/340 82/7206 0.00496280397687 ko05034 Alcoholism 3/340 238/7206 0.00725318379327 ko05134 Legionellosis 9/340 74/7206 0.00767213891259 ko04622 RIG-I-like receptor signaling pathway 8/340 62/7206 0.00824381499439 ko05145 Toxoplasmosis 13/340 126/7206 0.00841806146252 ko04062 Chemokine signaling pathway 18/340 201/7206 0.00984321319194 ko04664 Fc epsilon RI signaling pathway 9/340 77/7206 0.00990071779174 ko04640 Hematopoietic cell lineage 8/340 64/7206 0.00994974252031 ko00140 Steroid hormone biosynthesis 6/340 41/7206 0.0117300087057 ko04310 Wnt signaling pathway 2/340 181/7206 0.0124491028319 ko04728 Dopaminergic synapse 2/340 185/7206 0.0125973105325 ko04974 Protein digestion and absorption 10/340 96/7206 0.0146595293443 ko04710 Circadian rhythm 6/340 43/7206 0.0147023436549 ko04916 Melanogenesis 1/340 142/7206 0.0149099123987 ko04110 Cell cycle 1/340 145/7206 0.0153096923292 ko04659 Th17 cell differentiation 11/340 106/7206 0.0167594811958 ko05160 Hepatitis C 14/340 153/7206 0.0179597760542 ko05133 Pertussis 9/340 87/7206 0.0209142607478 ko04713 Circadian entrainment 1/340 136/7206 0.0219813679697 ko04120 Ubiquitin mediated proteolysis 1/340 138/7206 0.0225518266915 ko05132 Salmonella infection 10/340 98/7206 0.0252460392216 ko04612 Antigen processing and presentation 8/340 77/7206 0.0279757212927 ko00982 Drug metabolism - cytochrome P450 5/340 37/7206 0.0286068333725 ko04540 Gap junction 1/340 128/7206 0.0318552854522 ko04512 ECM-receptor interaction 8/340 79/7206 0.0320081479901 ko03010 Ribosome 1/340 129/7206 0.0322525709702 ko04390 Hippo signaling pathway 3/340 188/7206 0.0356505172378 ko04933 AGE-RAGE signaling pathway in diabetic complications 12/340 135/7206 0.0360414091124 ko04072 Phospholipase D signaling pathway 16/340 197/7206 0.0379476492858 ko04623 Cytosolic DNA-sensing pathway 5/340 41/7206 0.0422612182579 ko05161 Hepatitis B 14/340 173/7206 0.0438093282458 ko00051 Fructose and mannose metabolism 5/340 42/7206 0.046194153533 ko00401 Novobiocin biosynthesis 1/340 1/7206 0.0471829031365 ko04666 Fc gamma R-mediated phagocytosis 11/340 122/7206 0.0473523448421 ko04724 Glutamatergic synapse 2/340 152/7206 0.0496425621949