ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	213/1338	423/7206	4.16928181533e-53
ko04724	Glutamatergic synapse	95/1338	152/7206	1.24657067567e-33
ko05032	Morphine addiction	73/1338	110/7206	1.68047957217e-28
ko05033	Nicotine addiction	48/1338	56/7206	1.19019981135e-27
ko04727	GABAergic synapse	72/1338	110/7206	1.49448040444e-27
ko04713	Circadian entrainment	81/1338	136/7206	1.0016827335e-26
ko04725	Cholinergic synapse	82/1338	160/7206	3.71379753285e-21
ko04728	Dopaminergic synapse	89/1338	185/7206	1.8434946711e-20
ko04721	Synaptic vesicle cycle	52/1338	80/7206	5.27524110055e-20
ko04024	cAMP signaling pathway	113/1338	279/7206	3.10282922521e-18
ko04020	Calcium signaling pathway	109/1338	265/7206	3.3496308658e-18
ko04723	Retrograde endocannabinoid signaling	80/1338	175/7206	7.61836829515e-17
ko04911	Insulin secretion	61/1338	117/7206	1.6956297765e-16
ko04726	Serotonergic synapse	67/1338	137/7206	3.87456741201e-16
ko04921	Oxytocin signaling pathway	84/1338	209/7206	1.51879377844e-13
ko04744	Phototransduction	27/1338	36/7206	2.40020029771e-13
ko05031	Amphetamine addiction	47/1338	91/7206	8.32947907737e-13
ko04970	Salivary secretion	48/1338	95/7206	1.37250473097e-12
ko04742	Taste transduction	36/1338	61/7206	2.19622547896e-12
ko04720	Long-term potentiation	48/1338	99/7206	9.4967679119e-12
ko03040	Spliceosome	2/1338	145/7206	8.22199232704e-11
ko03010	Ribosome	1/1338	129/7206	1.21369901996e-10
ko04740	Olfactory transduction	39/1338	80/7206	6.97246795175e-10
ko04261	Adrenergic signaling in cardiomyocytes	75/1338	205/7206	7.26669333971e-10
ko04925	Aldosterone synthesis and secretion	45/1338	105/7206	6.65046166885e-09
ko04022	cGMP-PKG signaling pathway	75/1338	216/7206	1.15264966015e-08
ko05322	Systemic lupus erythematosus	5/1338	151/7206	1.799771567e-08
ko05168	Herpes simplex infection	8/1338	182/7206	1.87181985072e-08
ko03013	RNA transport	7/1338	166/7206	4.68961768869e-08
ko04070	Phosphatidylinositol signaling system	44/1338	112/7206	2.33392235561e-07
ko04971	Gastric acid secretion	40/1338	98/7206	2.55110814154e-07
ko05203	Viral carcinogenesis	22/1338	277/7206	5.4034115889e-07
ko05030	Cocaine addiction	32/1338	73/7206	8.11422065383e-07
ko04730	Long-term depression	33/1338	78/7206	1.04853392739e-06
ko04110	Cell cycle	7/1338	145/7206	1.41342657687e-06
ko04141	Protein processing in endoplasmic reticulum	12/1338	184/7206	3.08779567922e-06
ko04972	Pancreatic secretion	41/1338	111/7206	5.55861232704e-06
ko04540	Gap junction	45/1338	128/7206	8.59657960509e-06
ko04966	Collecting duct acid secretion	15/1338	26/7206	9.7900500336e-06
ko04060	Cytokine-cytokine receptor interaction	14/1338	191/7206	1.1744746773e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1338	74/7206	1.25147624598e-05
ko04924	Renin secretion	33/1338	86/7206	1.62244104564e-05
ko04072	Phospholipase D signaling pathway	61/1338	197/7206	2.343325854e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1338	79/7206	2.80016549109e-05
ko04621	NOD-like receptor signaling pathway	11/1338	157/7206	4.39568805667e-05
ko04976	Bile secretion	30/1338	80/7206	6.22852210995e-05
ko04750	Inflammatory mediator regulation of TRP channels	41/1338	122/7206	8.0912389745e-05
ko04360	Axon guidance	67/1338	233/7206	0.000107272717546
ko05164	Influenza A	13/1338	167/7206	0.000111214716986
ko04010	MAPK signaling pathway	87/1338	321/7206	0.000124020203586
ko04514	Cell adhesion molecules (CAMs)	42/1338	130/7206	0.000143957935228
ko04014	Ras signaling pathway	77/1338	279/7206	0.000153360277727
ko04745	Phototransduction - fly	17/1338	38/7206	0.000184203882778
ko04923	Regulation of lipolysis in adipocytes	28/1338	77/7206	0.000185314786323
ko05169	Epstein-Barr virus infection	19/1338	206/7206	0.000247973542549
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1338	59/7206	0.000264083224243
ko00520	Amino sugar and nucleotide sugar metabolism	1/1338	55/7206	0.00032835996565
ko04371	Apelin signaling pathway	52/1338	177/7206	0.000387739758027
ko04120	Ubiquitin mediated proteolysis	11/1338	138/7206	0.000566184792985
ko05162	Measles	9/1338	120/7206	0.000829113284786
ko05110	Vibrio cholerae infection	23/1338	63/7206	0.000844179487196
ko04612	Antigen processing and presentation	4/1338	77/7206	0.00102526970598
ko04964	Proximal tubule bicarbonate reclamation	13/1338	29/7206	0.00102971577055
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1338	79/7206	0.00110790967445
ko04710	Circadian rhythm	17/1338	43/7206	0.00119874387208
ko05414	Dilated cardiomyopathy	35/1338	112/7206	0.00126244865673
ko05140	Leishmaniasis	4/1338	75/7206	0.00148031762317
ko04260	Cardiac muscle contraction	31/1338	98/7206	0.0015640675458
ko03420	Nucleotide excision repair	1/1338	46/7206	0.00175874657754
ko04922	Glucagon signaling pathway	38/1338	128/7206	0.0018657197147
ko04270	Vascular smooth muscle contraction	44/1338	154/7206	0.00222344093702
ko04973	Carbohydrate digestion and absorption	16/1338	42/7206	0.00249759213535
ko05145	Toxoplasmosis	11/1338	126/7206	0.00256355171915
ko03022	Basal transcription factors	1/1338	44/7206	0.00271010471514
ko04622	RIG-I-like receptor signaling pathway	3/1338	62/7206	0.00276879605309
ko04915	Estrogen signaling pathway	38/1338	131/7206	0.00306203705754
ko04657	IL-17 signaling pathway	6/1338	87/7206	0.00321841590469
ko05133	Pertussis	6/1338	87/7206	0.00321841590469
ko03018	RNA degradation	6/1338	84/7206	0.0044431724028
ko04217	Necroptosis	19/1338	178/7206	0.0045554429709
ko05231	Choline metabolism in cancer	38/1338	134/7206	0.00487196527242
ko05205	Proteoglycans in cancer	33/1338	271/7206	0.00517582270427
ko04146	Peroxisome	7/1338	89/7206	0.0059646064203
ko05166	HTLV-I infection	37/1338	292/7206	0.00707485733019
ko04350	TGF-beta signaling pathway	9/1338	103/7206	0.00715937875761
ko04960	Aldosterone-regulated sodium reabsorption	15/1338	41/7206	0.00716829428913
ko05161	Hepatitis B	19/1338	173/7206	0.00745272593137
ko04658	Th1 and Th2 cell differentiation	8/1338	96/7206	0.0077182142333
ko00562	Inositol phosphate metabolism	27/1338	89/7206	0.00842257079953
ko04610	Complement and coagulation cascades	6/1338	79/7206	0.00851060022601
ko05321	Inflammatory bowel disease (IBD)	3/1338	56/7206	0.00856372870228
ko04626	Plant-pathogen interaction	8/1338	18/7206	0.010335004923
ko00280	Valine, leucine and isoleucine degradation	3/1338	54/7206	0.0124574784839
ko04330	Notch signaling pathway	4/1338	62/7206	0.0126442253587
ko04210	Apoptosis	21/1338	180/7206	0.0149333349234
ko05131	Shigellosis	7/1338	82/7206	0.0150623436418
ko04918	Thyroid hormone synthesis	25/1338	86/7206	0.0169124080188
ko04064	NF-kappa B signaling pathway	9/1338	96/7206	0.0170674520348
ko04630	Jak-STAT signaling pathway	14/1338	132/7206	0.0171327946304
ko00240	Pyrimidine metabolism	11/1338	110/7206	0.018403131045
ko04912	GnRH signaling pathway	33/1338	122/7206	0.0186521051403
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1338	100/7206	0.0192298168116
ko05214	Glioma	23/1338	79/7206	0.0196506211993
ko04930	Type II diabetes mellitus	17/1338	54/7206	0.0210604640527
ko04214	Apoptosis - fly	6/1338	72/7206	0.0218906645655
ko05219	Bladder cancer	3/1338	48/7206	0.0245493647207
ko04113	Meiosis - yeast	6/1338	70/7206	0.0297709497564
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1338	14/7206	0.0313068054463
ko04062	Chemokine signaling pathway	49/1338	201/7206	0.0344570283645
ko03410	Base excision repair	2/1338	38/7206	0.0345084739593
ko00480	Glutathione metabolism	4/1338	55/7206	0.0346408840923
ko05144	Malaria	3/1338	45/7206	0.034924694731
ko00071	Fatty acid degradation	3/1338	45/7206	0.034924694731
ko05202	Transcriptional misregulation in cancer	24/1338	188/7206	0.0366316374961
ko04916	Melanogenesis	36/1338	142/7206	0.0386622205326
ko05217	Basal cell carcinoma	6/1338	68/7206	0.0403859161335
ko04962	Vasopressin-regulated water reabsorption	17/1338	58/7206	0.0414810110817
ko04932	Non-alcoholic fatty liver disease (NAFLD)	23/1338	182/7206	0.0419652286247
ko00310	Lysine degradation	7/1338	73/7206	0.0486948761581
ko04115	p53 signaling pathway	7/1338	74/7206	0.0492301476155