ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	179/1074	423/7206	1.99199522064e-45
ko04724	Glutamatergic synapse	86/1074	152/7206	2.28242345897e-33
ko05033	Nicotine addiction	48/1074	56/7206	3.55335542784e-32
ko05032	Morphine addiction	67/1074	110/7206	7.75018722297e-29
ko04727	GABAergic synapse	64/1074	110/7206	5.44999891136e-26
ko04713	Circadian entrainment	69/1074	136/7206	3.42748924145e-23
ko04725	Cholinergic synapse	73/1074	160/7206	5.82096606852e-21
ko04728	Dopaminergic synapse	79/1074	185/7206	2.15401479191e-20
ko04723	Retrograde endocannabinoid signaling	75/1074	175/7206	1.60280611184e-19
ko04721	Synaptic vesicle cycle	46/1074	80/7206	1.03744118175e-18
ko04024	cAMP signaling pathway	99/1074	279/7206	2.9896171736e-18
ko04742	Taste transduction	35/1074	61/7206	1.69760191096e-14
ko04911	Insulin secretion	51/1074	117/7206	5.28919472043e-14
ko04020	Calcium signaling pathway	86/1074	265/7206	2.11087517859e-13
ko04921	Oxytocin signaling pathway	72/1074	209/7206	7.64151416116e-13
ko04261	Adrenergic signaling in cardiomyocytes	71/1074	205/7206	8.67604666761e-13
ko04744	Phototransduction	24/1074	36/7206	2.36409184109e-12
ko04726	Serotonergic synapse	53/1074	137/7206	5.34070183545e-12
ko05031	Amphetamine addiction	38/1074	91/7206	4.24105723511e-10
ko03040	Spliceosome	1/1074	145/7206	2.19803127453e-09
ko04720	Long-term potentiation	38/1074	99/7206	7.32315224622e-09
ko05030	Cocaine addiction	30/1074	73/7206	4.61187203609e-08
ko04925	Aldosterone synthesis and secretion	38/1074	105/7206	4.75302286894e-08
ko04360	Axon guidance	65/1074	233/7206	1.82632213616e-07
ko05203	Viral carcinogenesis	14/1074	277/7206	2.61001308716e-07
ko04970	Salivary secretion	34/1074	95/7206	5.25531562088e-07
ko04971	Gastric acid secretion	34/1074	98/7206	8.82820866126e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1074	74/7206	9.86388914235e-07
ko04022	cGMP-PKG signaling pathway	59/1074	216/7206	1.50022642191e-06
ko05168	Herpes simplex infection	7/1074	182/7206	2.28583313976e-06
ko05164	Influenza A	6/1074	167/7206	2.67623858444e-06
ko03013	RNA transport	6/1074	166/7206	4.01052257449e-06
ko05322	Systemic lupus erythematosus	5/1074	151/7206	4.56001009159e-06
ko04514	Cell adhesion molecules (CAMs)	39/1074	130/7206	8.93449537713e-06
ko04972	Pancreatic secretion	35/1074	111/7206	9.51413447875e-06
ko04072	Phospholipase D signaling pathway	53/1074	197/7206	9.66248472834e-06
ko04060	Cytokine-cytokine receptor interaction	9/1074	191/7206	1.13091215208e-05
ko04010	MAPK signaling pathway	75/1074	321/7206	3.86835736785e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1074	79/7206	4.59493708754e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1074	79/7206	8.36657901337e-05
ko04141	Protein processing in endoplasmic reticulum	10/1074	184/7206	8.52613807446e-05
ko04621	NOD-like receptor signaling pathway	8/1074	157/7206	0.000154015539309
ko04260	Cardiac muscle contraction	29/1074	98/7206	0.000161863350201
ko05205	Proteoglycans in cancer	20/1074	271/7206	0.000169900197402
ko04740	Olfactory transduction	25/1074	80/7206	0.000190241786188
ko05414	Dilated cardiomyopathy	32/1074	112/7206	0.000230275025963
ko04070	Phosphatidylinositol signaling system	32/1074	112/7206	0.000230275025963
ko05169	Epstein-Barr virus infection	14/1074	206/7206	0.000461549513162
ko04612	Antigen processing and presentation	2/1074	77/7206	0.00061648073173
ko04745	Phototransduction - fly	14/1074	38/7206	0.000709470083823
ko04976	Bile secretion	23/1074	80/7206	0.00130776791397
ko04120	Ubiquitin mediated proteolysis	8/1074	138/7206	0.00150011013881
ko05161	Hepatitis B	12/1074	173/7206	0.00163907179396
ko04915	Estrogen signaling pathway	33/1074	131/7206	0.00177944293976
ko04923	Regulation of lipolysis in adipocytes	22/1074	77/7206	0.00185552464023
ko04110	Cell cycle	9/1074	145/7206	0.00196992286346
ko04730	Long-term depression	22/1074	78/7206	0.00209742720211
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1074	14/7206	0.00210081064091
ko05162	Measles	7/1074	120/7206	0.00277587309317
ko04966	Collecting duct acid secretion	10/1074	26/7206	0.00282056489985
ko04924	Renin secretion	23/1074	86/7206	0.0035778951461
ko04640	Hematopoietic cell lineage	2/1074	64/7206	0.00418703814756
ko05140	Leishmaniasis	3/1074	75/7206	0.00489815650093
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1074	59/7206	0.00522399471244
ko04540	Gap junction	31/1074	128/7206	0.00539554709244
ko04064	NF-kappa B signaling pathway	5/1074	96/7206	0.005479421929
ko00330	Arginine and proline metabolism	2/1074	61/7206	0.00608670192919
ko05110	Vibrio cholerae infection	18/1074	63/7206	0.00649306513363
ko04964	Proximal tubule bicarbonate reclamation	10/1074	29/7206	0.00697592412605
ko04918	Thyroid hormone synthesis	22/1074	86/7206	0.00885212532296
ko04750	Inflammatory mediator regulation of TRP channels	29/1074	122/7206	0.00964945220705
ko00240	Pyrimidine metabolism	7/1074	110/7206	0.00965946187837
ko04014	Ras signaling pathway	57/1074	279/7206	0.0100662730314
ko04146	Peroxisome	5/1074	89/7206	0.0102345429919
ko00230	Purine metabolism	42/1074	194/7206	0.0103387420334
ko05144	Malaria	1/1074	45/7206	0.0105675550503
ko00071	Fatty acid degradation	1/1074	45/7206	0.0105675550503
ko03420	Nucleotide excision repair	1/1074	46/7206	0.0108425959522
ko04930	Type II diabetes mellitus	15/1074	54/7206	0.0120977917946
ko05321	Inflammatory bowel disease (IBD)	2/1074	56/7206	0.0129452720362
ko04658	Th1 and Th2 cell differentiation	6/1074	96/7206	0.013551664058
ko04657	IL-17 signaling pathway	5/1074	87/7206	0.0142901205876
ko05133	Pertussis	5/1074	87/7206	0.0142901205876
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1074	100/7206	0.0153513796452
ko03022	Basal transcription factors	1/1074	44/7206	0.0167315710454
ko04371	Apelin signaling pathway	38/1074	177/7206	0.0181531455626
ko00590	Arachidonic acid metabolism	2/1074	52/7206	0.0184992123424
ko05131	Shigellosis	5/1074	82/7206	0.0192675999204
ko04137	Mitophagy - animal	5/1074	82/7206	0.0192675999204
ko05231	Choline metabolism in cancer	30/1074	134/7206	0.0193353216039
ko03018	RNA degradation	5/1074	84/7206	0.019538206104
ko04622	RIG-I-like receptor signaling pathway	3/1074	62/7206	0.0196693094172
ko00310	Lysine degradation	4/1074	73/7206	0.0198146453184
ko04115	p53 signaling pathway	4/1074	74/7206	0.0201347757386
ko05215	Prostate cancer	8/1074	111/7206	0.0214420693889
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1074	40/7206	0.0235957377669
ko04218	Cellular senescence	16/1074	177/7206	0.0245965383381
ko03320	PPAR signaling pathway	4/1074	69/7206	0.0274038576438
ko04270	Vascular smooth muscle contraction	33/1074	154/7206	0.0289457361184
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1074	182/7206	0.0343576754896
ko00982	Drug metabolism - cytochrome P450	1/1074	37/7206	0.0347957071053
ko04140	Autophagy - animal	15/1074	164/7206	0.0348764206328
ko04630	Jak-STAT signaling pathway	11/1074	132/7206	0.0349870000079
ko00630	Glyoxylate and dicarboxylate metabolism	1/1074	38/7206	0.0359050849169
ko03410	Base excision repair	1/1074	38/7206	0.0359050849169
ko00260	Glycine, serine and threonine metabolism	2/1074	48/7206	0.0390993703941
ko05219	Bladder cancer	2/1074	48/7206	0.0390993703941
ko04217	Necroptosis	17/1074	178/7206	0.0425619119532
ko04210	Apoptosis	17/1074	180/7206	0.0431458578032
ko04620	Toll-like receptor signaling pathway	8/1074	100/7206	0.0482185411294
ko04670	Leukocyte transendothelial migration	14/1074	151/7206	0.0494736392186