ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	208/1314	423/7206	5.17467474154e-51
ko04724	Glutamatergic synapse	95/1314	152/7206	2.63761773602e-34
ko05032	Morphine addiction	73/1314	110/7206	5.01204806822e-29
ko04727	GABAergic synapse	72/1314	110/7206	4.56155173411e-28
ko05033	Nicotine addiction	48/1314	56/7206	5.07317830075e-28
ko04713	Circadian entrainment	80/1314	136/7206	1.89531349369e-26
ko04728	Dopaminergic synapse	90/1314	185/7206	1.14953794221e-21
ko04721	Synaptic vesicle cycle	52/1314	80/7206	2.2588432971e-20
ko04725	Cholinergic synapse	80/1314	160/7206	2.60139258409e-20
ko04723	Retrograde endocannabinoid signaling	81/1314	175/7206	6.22059524823e-18
ko04024	cAMP signaling pathway	110/1314	279/7206	3.33516839952e-17
ko04020	Calcium signaling pathway	106/1314	265/7206	4.14024038604e-17
ko04911	Insulin secretion	61/1314	117/7206	6.85441547552e-17
ko04726	Serotonergic synapse	66/1314	137/7206	6.56635696654e-16
ko04742	Taste transduction	39/1314	61/7206	3.1457168931e-15
ko04744	Phototransduction	28/1314	36/7206	1.05569100243e-14
ko04921	Oxytocin signaling pathway	81/1314	209/7206	1.86364145402e-12
ko05031	Amphetamine addiction	46/1314	91/7206	2.03244516211e-12
ko04970	Salivary secretion	46/1314	95/7206	1.42522979643e-11
ko04740	Olfactory transduction	41/1314	80/7206	1.84943766014e-11
ko04261	Adrenergic signaling in cardiomyocytes	76/1314	205/7206	8.98549238905e-11
ko03040	Spliceosome	2/1314	145/7206	1.36231279083e-10
ko04720	Long-term potentiation	45/1314	99/7206	3.39645193933e-10
ko05203	Viral carcinogenesis	19/1314	277/7206	4.6514228067e-08
ko04925	Aldosterone synthesis and secretion	43/1314	105/7206	5.34744908001e-08
ko03013	RNA transport	7/1314	166/7206	7.30554997349e-08
ko04022	cGMP-PKG signaling pathway	72/1314	216/7206	7.79607143735e-08
ko05168	Herpes simplex infection	9/1314	182/7206	1.51730476802e-07
ko05322	Systemic lupus erythematosus	6/1314	151/7206	1.81736386832e-07
ko05030	Cocaine addiction	32/1314	73/7206	3.4503712736e-07
ko04971	Gastric acid secretion	39/1314	98/7206	4.69533734451e-07
ko04966	Collecting duct acid secretion	16/1314	26/7206	1.15031501192e-06
ko04621	NOD-like receptor signaling pathway	8/1314	157/7206	1.70619116027e-06
ko04060	Cytokine-cytokine receptor interaction	12/1314	191/7206	2.3312476316e-06
ko04110	Cell cycle	7/1314	145/7206	3.24272714202e-06
ko04976	Bile secretion	32/1314	80/7206	5.71173307383e-06
ko04972	Pancreatic secretion	40/1314	111/7206	8.82278569024e-06
ko04514	Cell adhesion molecules (CAMs)	44/1314	130/7206	1.63717222186e-05
ko05164	Influenza A	11/1314	167/7206	1.68177450437e-05
ko04141	Protein processing in endoplasmic reticulum	13/1314	184/7206	1.69833910086e-05
ko04360	Axon guidance	69/1314	233/7206	1.96303382648e-05
ko04730	Long-term depression	30/1314	78/7206	2.2305838424e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1314	74/7206	2.33168235618e-05
ko04070	Phosphatidylinositol signaling system	39/1314	112/7206	3.22612505587e-05
ko04745	Phototransduction - fly	18/1314	38/7206	3.65191123338e-05
ko04750	Inflammatory mediator regulation of TRP channels	41/1314	122/7206	4.27568775389e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1314	79/7206	4.61661425886e-05
ko04010	MAPK signaling pathway	87/1314	321/7206	5.96432705897e-05
ko04924	Renin secretion	31/1314	86/7206	0.000100668363818
ko04120	Ubiquitin mediated proteolysis	9/1314	138/7206	0.000123968151976
ko05169	Epstein-Barr virus infection	18/1314	206/7206	0.000155504409624
ko04540	Gap junction	41/1314	128/7206	0.000175730915199
ko04014	Ras signaling pathway	76/1314	279/7206	0.000183610124802
ko04964	Proximal tubule bicarbonate reclamation	14/1314	29/7206	0.000209873057329
ko04612	Antigen processing and presentation	3/1314	77/7206	0.000289076583427
ko04922	Glucagon signaling pathway	40/1314	128/7206	0.00030077702821
ko05414	Dilated cardiomyopathy	36/1314	112/7206	0.000309478467299
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1314	79/7206	0.000318991090033
ko05140	Leishmaniasis	3/1314	75/7206	0.00042689757002
ko05162	Measles	8/1314	120/7206	0.000458933319669
ko05110	Vibrio cholerae infection	23/1314	63/7206	0.00048459401328
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1314	59/7206	0.000508432960876
ko04072	Phospholipase D signaling pathway	55/1314	197/7206	0.000701029207333
ko05205	Proteoglycans in cancer	29/1314	271/7206	0.000715236737379
ko04710	Circadian rhythm	17/1314	43/7206	0.00102342129594
ko04064	NF-kappa B signaling pathway	6/1314	96/7206	0.00120615435589
ko04260	Cardiac muscle contraction	31/1314	98/7206	0.00134661125419
ko03420	Nucleotide excision repair	1/1314	46/7206	0.00174498780843
ko05166	HTLV-I infection	34/1314	292/7206	0.00245406278057
ko04923	Regulation of lipolysis in adipocytes	25/1314	77/7206	0.0025832625615
ko03022	Basal transcription factors	1/1314	44/7206	0.00266262230439
ko05161	Hepatitis B	17/1314	173/7206	0.0026648189235
ko04371	Apelin signaling pathway	48/1314	177/7206	0.0029904011039
ko04610	Complement and coagulation cascades	5/1314	79/7206	0.0032324331217
ko04146	Peroxisome	6/1314	89/7206	0.00331307958697
ko05145	Toxoplasmosis	11/1314	126/7206	0.00349174331225
ko00240	Pyrimidine metabolism	9/1314	110/7206	0.00399989946712
ko04915	Estrogen signaling pathway	37/1314	131/7206	0.00416321052715
ko04330	Notch signaling pathway	3/1314	62/7206	0.00424141735495
ko04622	RIG-I-like receptor signaling pathway	3/1314	62/7206	0.00424141735495
ko04657	IL-17 signaling pathway	6/1314	87/7206	0.0046640077763
ko05133	Pertussis	6/1314	87/7206	0.0046640077763
ko04270	Vascular smooth muscle contraction	42/1314	154/7206	0.00575564333298
ko04930	Type II diabetes mellitus	18/1314	54/7206	0.00712818375498
ko04973	Carbohydrate digestion and absorption	15/1314	42/7206	0.00752589280343
ko04217	Necroptosis	19/1314	178/7206	0.0076396964313
ko05219	Bladder cancer	2/1314	48/7206	0.00767382362585
ko05321	Inflammatory bowel disease (IBD)	3/1314	56/7206	0.00849973639321
ko05131	Shigellosis	6/1314	82/7206	0.0088363684236
ko04214	Apoptosis - fly	5/1314	72/7206	0.00887502455072
ko04626	Plant-pathogen interaction	8/1314	18/7206	0.00925101667234
ko00630	Glyoxylate and dicarboxylate metabolism	1/1314	38/7206	0.00957273871858
ko04658	Th1 and Th2 cell differentiation	8/1314	96/7206	0.0107250735207
ko05144	Malaria	2/1314	45/7206	0.011187666704
ko00071	Fatty acid degradation	2/1314	45/7206	0.011187666704
ko04630	Jak-STAT signaling pathway	13/1314	132/7206	0.0117529786279
ko00280	Valine, leucine and isoleucine degradation	3/1314	54/7206	0.0122501287353
ko00520	Amino sugar and nucleotide sugar metabolism	3/1314	55/7206	0.012643250952
ko04960	Aldosterone-regulated sodium reabsorption	14/1314	41/7206	0.0135189528193
ko03018	RNA degradation	7/1314	84/7206	0.0152388233389
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1314	100/7206	0.0179433050455
ko04210	Apoptosis	21/1314	180/7206	0.0188665768267
ko00562	Inositol phosphate metabolism	25/1314	89/7206	0.0189131712339
ko04932	Non-alcoholic fatty liver disease (NAFLD)	21/1314	182/7206	0.0191135066637
ko05016	Huntington's disease	26/1314	215/7206	0.019305663001
ko04711	Circadian rhythm - fly	6/1314	13/7206	0.0194050331041
ko04350	TGF-beta signaling pathway	10/1314	103/7206	0.0206801817348
ko00965	Betalain biosynthesis	3/1314	4/7206	0.0209031378492
ko05231	Choline metabolism in cancer	35/1314	134/7206	0.0232174976562
ko04918	Thyroid hormone synthesis	24/1314	86/7206	0.0242528510709
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1314	14/7206	0.0288237453258
ko03015	mRNA surveillance pathway	9/1314	93/7206	0.0301314790592
ko04640	Hematopoietic cell lineage	5/1314	64/7206	0.0328456432597
ko00480	Glutathione metabolism	4/1314	55/7206	0.0342558909451
ko03410	Base excision repair	2/1314	38/7206	0.0346362341648
ko04620	Toll-like receptor signaling pathway	10/1314	100/7206	0.0357715778958
ko05418	Fluid shear stress and atherosclerosis	21/1314	173/7206	0.0360308162958
ko05217	Basal cell carcinoma	6/1314	68/7206	0.0405918534425
ko04062	Chemokine signaling pathway	48/1314	201/7206	0.0411705597663
ko04113	Meiosis - yeast	6/1314	70/7206	0.0413915724671
ko04142	Lysosome	18/1314	151/7206	0.042753192965
ko04912	GnRH signaling pathway	31/1314	122/7206	0.0440884611338
ko01212	Fatty acid metabolism	5/1314	60/7206	0.0441242198791
ko00330	Arginine and proline metabolism	5/1314	61/7206	0.0443290709003
ko04115	p53 signaling pathway	7/1314	74/7206	0.0491127084716