ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 38/393 152/7206 5.82252627808e-16 ko05033 Nicotine addiction 22/393 56/7206 3.49758229036e-14 ko04713 Circadian entrainment 32/393 136/7206 7.97849061654e-13 ko04080 Neuroactive ligand-receptor interaction 59/393 423/7206 8.64232392099e-12 ko05031 Amphetamine addiction 24/393 91/7206 4.88150179747e-11 ko04720 Long-term potentiation 25/393 99/7206 5.36785304161e-11 ko04727 GABAergic synapse 24/393 110/7206 3.29312093015e-09 ko04261 Adrenergic signaling in cardiomyocytes 34/393 205/7206 3.83770818404e-09 ko04728 Dopaminergic synapse 32/393 185/7206 3.87977926679e-09 ko04911 Insulin secretion 24/393 117/7206 1.20864655444e-08 ko04024 cAMP signaling pathway 40/393 279/7206 1.216209622e-08 ko04921 Oxytocin signaling pathway 33/393 209/7206 2.31625429402e-08 ko04020 Calcium signaling pathway 38/393 265/7206 2.87571639046e-08 ko04723 Retrograde endocannabinoid signaling 29/393 175/7206 5.7558318388e-08 ko05032 Morphine addiction 22/393 110/7206 8.03978200393e-08 ko04730 Long-term depression 18/393 78/7206 1.27642486338e-07 ko04970 Salivary secretion 20/393 95/7206 1.30013465288e-07 ko04925 Aldosterone synthesis and secretion 19/393 105/7206 3.07706891789e-06 ko04745 Phototransduction - fly 11/393 38/7206 3.49131766469e-06 ko04721 Synaptic vesicle cycle 16/393 80/7206 4.86822972436e-06 ko05030 Cocaine addiction 15/393 73/7206 6.80233289656e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 15/393 74/7206 8.11404445679e-06 ko04725 Cholinergic synapse 23/393 160/7206 1.65396463282e-05 ko04971 Gastric acid secretion 17/393 98/7206 1.82719023251e-05 ko04514 Cell adhesion molecules (CAMs) 19/393 130/7206 7.15411445155e-05 ko04726 Serotonergic synapse 19/393 137/7206 0.000146633662473 ko04360 Axon guidance 27/393 233/7206 0.000178191531179 ko04924 Renin secretion 14/393 86/7206 0.000202019168189 ko04070 Phosphatidylinositol signaling system 16/393 112/7206 0.000344767013709 ko04740 Olfactory transduction 13/393 80/7206 0.000345444573301 ko04010 MAPK signaling pathway 33/393 321/7206 0.000363425248175 ko04930 Type II diabetes mellitus 10/393 54/7206 0.000572857712215 ko04260 Cardiac muscle contraction 14/393 98/7206 0.000799397784618 ko04022 cGMP-PKG signaling pathway 24/393 216/7206 0.0010928458721 ko04960 Aldosterone-regulated sodium reabsorption 8/393 41/7206 0.00142112020148 ko04014 Ras signaling pathway 28/393 279/7206 0.00169773119134 ko04710 Circadian rhythm 8/393 43/7206 0.00196044812485 ko04626 Plant-pathogen interaction 5/393 18/7206 0.00223120046125 ko04922 Glucagon signaling pathway 16/393 128/7206 0.00223440926567 ko05010 Alzheimer's disease 22/393 202/7206 0.00228348265153 ko04972 Pancreatic secretion 14/393 111/7206 0.00270362888461 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 11/393 79/7206 0.00349346432837 ko05214 Glioma 11/393 79/7206 0.00349346432837 ko04711 Circadian rhythm - fly 4/393 13/7206 0.00420183107086 ko05168 Herpes simplex infection 2/393 182/7206 0.00431963305691 ko04141 Protein processing in endoplasmic reticulum 2/393 184/7206 0.00440610087793 ko04742 Taste transduction 9/393 61/7206 0.00541378312658 ko04722 Neurotrophin signaling pathway 17/393 160/7206 0.00734886948903 ko03010 Ribosome 1/393 129/7206 0.0100650424086 ko04966 Collecting duct acid secretion 5/393 26/7206 0.0119600933551 ko04114 Oocyte meiosis 15/393 139/7206 0.0120049848943 ko04621 NOD-like receptor signaling pathway 2/393 157/7206 0.0122648579824 ko04072 Phospholipase D signaling pathway 19/393 197/7206 0.0154802185257 ko04012 ErbB signaling pathway 12/393 109/7206 0.0173252330192 ko05322 Systemic lupus erythematosus 2/393 151/7206 0.0173757722837 ko04912 GnRH signaling pathway 13/393 122/7206 0.0234334622783 ko04540 Gap junction 13/393 128/7206 0.0279824863321 ko05034 Alcoholism 21/393 238/7206 0.0280601935069 ko04270 Vascular smooth muscle contraction 15/393 154/7206 0.0286732529938 ko05203 Viral carcinogenesis 7/393 277/7206 0.029468635444 ko05166 HTLV-I infection 8/393 292/7206 0.0346585812173 ko04060 Cytokine-cytokine receptor interaction 4/393 191/7206 0.0347344502213 ko04120 Ubiquitin mediated proteolysis 2/393 138/7206 0.0347795200042 ko03013 RNA transport 3/393 166/7206 0.035778577493 ko05164 Influenza A 3/393 167/7206 0.0360711379701 ko04750 Inflammatory mediator regulation of TRP channels 12/393 122/7206 0.041799238934 ko04015 Rap1 signaling pathway 23/393 278/7206 0.0423430876011 ko04744 Phototransduction 5/393 36/7206 0.0440293456824 ko02024 Quorum sensing 3/393 15/7206 0.0449073709204 ko04932 Non-alcoholic fatty liver disease (NAFLD) 4/393 182/7206 0.0467534983665 ko05200 Pathways in cancer 17/393 492/7206 0.0496995613423