ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 32/331 152/7206 1.80222079961e-13 ko04721 Synaptic vesicle cycle 21/331 80/7206 3.64438467921e-11 ko04728 Dopaminergic synapse 32/331 185/7206 4.76084147633e-11 ko04727 GABAergic synapse 22/331 110/7206 3.50110282225e-09 ko04725 Cholinergic synapse 26/331 160/7206 1.3307459136e-08 ko05033 Nicotine addiction 15/331 56/7206 1.82436975923e-08 ko04713 Circadian entrainment 22/331 136/7206 1.96548686073e-07 ko04723 Retrograde endocannabinoid signaling 24/331 175/7206 1.26064809888e-06 ko04964 Proximal tubule bicarbonate reclamation 9/331 29/7206 3.61814272641e-06 ko04911 Insulin secretion 18/331 117/7206 5.43308384568e-06 ko04514 Cell adhesion molecules (CAMs) 19/331 130/7206 6.46695751138e-06 ko04726 Serotonergic synapse 19/331 137/7206 1.40523319417e-05 ko05032 Morphine addiction 16/331 110/7206 3.71451038604e-05 ko05203 Viral carcinogenesis 1/331 277/7206 4.97750479181e-05 ko04261 Adrenergic signaling in cardiomyocytes 23/331 205/7206 5.98700133417e-05 ko04970 Salivary secretion 13/331 95/7206 0.000368679839994 ko04080 Neuroactive ligand-receptor interaction 35/331 423/7206 0.000678667654 ko05031 Amphetamine addiction 12/331 91/7206 0.0008644457268 ko04360 Axon guidance 22/331 233/7206 0.00117833056888 ko04745 Phototransduction - fly 7/331 38/7206 0.00149079131659 ko04720 Long-term potentiation 12/331 99/7206 0.00182310107142 ko04971 Gastric acid secretion 11/331 98/7206 0.00508659797053 ko04961 Endocrine and other factor-regulated calcium reabsorption 8/331 59/7206 0.00520775122592 ko04024 cAMP signaling pathway 23/331 279/7206 0.00537850151487 ko04924 Renin secretion 10/331 86/7206 0.00578515750603 ko04966 Collecting duct acid secretion 5/331 26/7206 0.00587836973195 ko05014 Amyotrophic lateral sclerosis (ALS) 9/331 74/7206 0.0064693730749 ko05164 Influenza A 1/331 167/7206 0.00738212653897 ko04730 Long-term depression 9/331 78/7206 0.00909776584853 ko04978 Mineral absorption 6/331 40/7206 0.00918744023063 ko04060 Cytokine-cytokine receptor interaction 2/331 191/7206 0.012714686957 ko05166 HTLV-I infection 5/331 292/7206 0.0141408761761 ko04940 Type I diabetes mellitus 5/331 32/7206 0.0143758643774 ko04020 Calcium signaling pathway 21/331 265/7206 0.0153339137553 ko04972 Pancreatic secretion 11/331 111/7206 0.0178756691619 ko04010 MAPK signaling pathway 24/331 321/7206 0.0191480537589 ko04120 Ubiquitin mediated proteolysis 1/331 138/7206 0.0217089172283 ko04391 Hippo signaling pathway - fly 9/331 90/7206 0.0218630203277 ko04744 Phototransduction 5/331 36/7206 0.0231932761968 ko05110 Vibrio cholerae infection 7/331 63/7206 0.0246297713798 ko05205 Proteoglycans in cancer 5/331 271/7206 0.0252310726054 ko02024 Quorum sensing 3/331 15/7206 0.0289663228063 ko04976 Bile secretion 8/331 80/7206 0.029782132593 ko04611 Platelet activation 2/331 163/7206 0.0350812709994 ko05120 Epithelial cell signaling in Helicobacter pylori infection 9/331 92/7206 0.0376979191902 ko04960 Aldosterone-regulated sodium reabsorption 5/331 41/7206 0.0383265577223 ko04014 Ras signaling pathway 20/331 279/7206 0.0411512150515 ko04973 Carbohydrate digestion and absorption 5/331 42/7206 0.0419341421458 ko04974 Protein digestion and absorption 9/331 96/7206 0.042281003779 ko04260 Cardiac muscle contraction 9/331 98/7206 0.0451678037575 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/331 1/7206 0.0459339439355 ko04626 Plant-pathogen interaction 3/331 18/7206 0.0469584187865 ko05016 Huntington's disease 4/331 215/7206 0.0472250272684 ko05030 Cocaine addiction 7/331 73/7206 0.0493833459643