ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	193/1255	423/7206	3.10612239501e-44
ko04724	Glutamatergic synapse	90/1255	152/7206	1.51841787791e-31
ko05033	Nicotine addiction	47/1255	56/7206	1.529491963e-27
ko05032	Morphine addiction	70/1255	110/7206	1.81737390833e-27
ko04713	Circadian entrainment	78/1255	136/7206	3.59033091062e-26
ko04727	GABAergic synapse	65/1255	110/7206	5.63425588726e-23
ko04725	Cholinergic synapse	80/1255	160/7206	1.28794494972e-21
ko04728	Dopaminergic synapse	85/1255	185/7206	7.70779128653e-20
ko04723	Retrograde endocannabinoid signaling	81/1255	175/7206	3.36791730555e-19
ko04020	Calcium signaling pathway	102/1255	265/7206	1.00263994451e-16
ko04024	cAMP signaling pathway	105/1255	279/7206	1.97628255633e-16
ko04911	Insulin secretion	58/1255	117/7206	9.12292902132e-16
ko04721	Synaptic vesicle cycle	45/1255	80/7206	3.7189597099e-15
ko04921	Oxytocin signaling pathway	82/1255	209/7206	3.17984473789e-14
ko04726	Serotonergic synapse	60/1255	137/7206	3.39992525368e-13
ko04742	Taste transduction	35/1255	61/7206	2.02433232929e-12
ko03040	Spliceosome	1/1255	145/7206	4.40592610326e-11
ko04720	Long-term potentiation	45/1255	99/7206	6.98536413312e-11
ko04261	Adrenergic signaling in cardiomyocytes	74/1255	205/7206	7.24714009116e-11
ko05031	Amphetamine addiction	42/1255	91/7206	1.66581416991e-10
ko04744	Phototransduction	23/1255	36/7206	6.61450203412e-10
ko03010	Ribosome	1/1255	129/7206	9.66618851846e-10
ko04970	Salivary secretion	41/1255	95/7206	3.36954307125e-09
ko04022	cGMP-PKG signaling pathway	72/1255	216/7206	8.50865727319e-09
ko04360	Axon guidance	76/1255	233/7206	1.03567480732e-08
ko04925	Aldosterone synthesis and secretion	43/1255	105/7206	1.12702665584e-08
ko03013	RNA transport	6/1255	166/7206	6.55599647681e-08
ko05322	Systemic lupus erythematosus	5/1255	151/7206	1.05886913647e-07
ko04014	Ras signaling pathway	82/1255	279/7206	4.59699376465e-07
ko04971	Gastric acid secretion	38/1255	98/7206	5.17656315408e-07
ko04010	MAPK signaling pathway	91/1255	321/7206	7.6995749271e-07
ko04070	Phosphatidylinositol signaling system	41/1255	112/7206	9.3975134963e-07
ko04072	Phospholipase D signaling pathway	61/1255	197/7206	2.25547446326e-06
ko04730	Long-term depression	31/1255	78/7206	2.72186013012e-06
ko04740	Olfactory transduction	31/1255	80/7206	4.74734279927e-06
ko05203	Viral carcinogenesis	22/1255	277/7206	5.18086206867e-06
ko05030	Cocaine addiction	29/1255	73/7206	5.94240502181e-06
ko05168	Herpes simplex infection	11/1255	182/7206	6.72295982085e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1255	74/7206	7.73268480619e-06
ko04745	Phototransduction - fly	18/1255	38/7206	1.9096976832e-05
ko04972	Pancreatic secretion	38/1255	111/7206	2.02981103748e-05
ko04514	Cell adhesion molecules (CAMs)	42/1255	130/7206	3.20803281911e-05
ko05164	Influenza A	11/1255	167/7206	4.9060563136e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1255	79/7206	7.01497470651e-05
ko04750	Inflammatory mediator regulation of TRP channels	39/1255	122/7206	8.79082018822e-05
ko04612	Antigen processing and presentation	2/1255	77/7206	0.00010638212526
ko04540	Gap junction	40/1255	128/7206	0.00013117005177
ko04270	Vascular smooth muscle contraction	45/1255	154/7206	0.000233670086574
ko04110	Cell cycle	10/1255	145/7206	0.000343493760393
ko04915	Estrogen signaling pathway	39/1255	131/7206	0.000424189104694
ko04930	Type II diabetes mellitus	20/1255	54/7206	0.000479480819331
ko04924	Renin secretion	28/1255	86/7206	0.000520573638386
ko04710	Circadian rhythm	17/1255	43/7206	0.000753198415417
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1255	79/7206	0.000814168607249
ko04015	Rap1 signaling pathway	70/1255	278/7206	0.000893167232558
ko05162	Measles	8/1255	120/7206	0.000918895983258
ko05169	Epstein-Barr virus infection	19/1255	206/7206	0.00103835281766
ko04141	Protein processing in endoplasmic reticulum	16/1255	184/7206	0.00105855040306
ko04621	NOD-like receptor signaling pathway	13/1255	157/7206	0.00132584502236
ko05231	Choline metabolism in cancer	38/1255	134/7206	0.00170741927212
ko04916	Melanogenesis	39/1255	142/7206	0.00241623934825
ko04371	Apelin signaling pathway	47/1255	177/7206	0.00242517242662
ko04966	Collecting duct acid secretion	11/1255	26/7206	0.00257079736676
ko05144	Malaria	1/1255	45/7206	0.00277967438603
ko00071	Fatty acid degradation	1/1255	45/7206	0.00277967438603
ko03420	Nucleotide excision repair	1/1255	46/7206	0.00278716777799
ko05414	Dilated cardiomyopathy	32/1255	112/7206	0.00350449939899
ko03022	Basal transcription factors	1/1255	44/7206	0.00426151815023
ko04976	Bile secretion	24/1255	80/7206	0.00466917006653
ko04146	Peroxisome	6/1255	89/7206	0.00471216709086
ko04060	Cytokine-cytokine receptor interaction	19/1255	191/7206	0.00483095806347
ko04923	Regulation of lipolysis in adipocytes	23/1255	77/7206	0.00617189559371
ko05110	Vibrio cholerae infection	20/1255	63/7206	0.00656219275917
ko04610	Complement and coagulation cascades	5/1255	79/7206	0.00664738157761
ko04260	Cardiac muscle contraction	28/1255	98/7206	0.00668012433401
ko04626	Plant-pathogen interaction	8/1255	18/7206	0.0069610473734
ko04912	GnRH signaling pathway	33/1255	122/7206	0.00760743074265
ko03018	RNA degradation	6/1255	84/7206	0.00895884094093
ko03410	Base excision repair	1/1255	38/7206	0.0095023612579
ko04964	Proximal tubule bicarbonate reclamation	11/1255	29/7206	0.0107958674528
ko04960	Aldosterone-regulated sodium reabsorption	14/1255	41/7206	0.0109810523257
ko00260	Glycine, serine and threonine metabolism	2/1255	48/7206	0.011707451595
ko05230	Central carbon metabolism in cancer	23/1255	81/7206	0.0120694892739
ko04120	Ubiquitin mediated proteolysis	13/1255	138/7206	0.0120959574686
ko04115	p53 signaling pathway	5/1255	74/7206	0.0128305330769
ko05140	Leishmaniasis	5/1255	75/7206	0.013175638279
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1255	59/7206	0.0142442860434
ko04064	NF-kappa B signaling pathway	8/1255	96/7206	0.0145958700299
ko04672	Intestinal immune network for IgA production	1/1255	37/7206	0.0146161023786
ko04711	Circadian rhythm - fly	6/1255	13/7206	0.0155757021606
ko04217	Necroptosis	19/1255	178/7206	0.015899391315
ko04922	Glucagon signaling pathway	33/1255	128/7206	0.01792101887
ko00280	Valine, leucine and isoleucine degradation	3/1255	54/7206	0.0180449818807
ko04622	RIG-I-like receptor signaling pathway	4/1255	62/7206	0.0180862458125
ko05016	Huntington's disease	25/1255	215/7206	0.0222268581107
ko00500	Starch and sucrose metabolism	1/1255	35/7206	0.0223401100774
ko04142	Lysosome	16/1255	151/7206	0.0227806739392
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1255	14/7206	0.0233147249955
ko03320	PPAR signaling pathway	5/1255	69/7206	0.0243697789965
ko04113	Meiosis - yeast	5/1255	70/7206	0.0249730047715
ko01200	Carbon metabolism	13/1255	128/7206	0.0256001356777
ko00590	Arachidonic acid metabolism	3/1255	52/7206	0.0258592826817
ko04071	Sphingolipid signaling pathway	39/1255	162/7206	0.0276471989072
ko04918	Thyroid hormone synthesis	23/1255	86/7206	0.0306073535835
ko04114	Oocyte meiosis	34/1255	139/7206	0.0316499642404
ko05012	Parkinson's disease	17/1255	155/7206	0.031918114446
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1255	100/7206	0.0323967545596
ko05205	Proteoglycans in cancer	34/1255	271/7206	0.0333889836571
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1255	40/7206	0.0355351127184
ko05214	Glioma	21/1255	79/7206	0.0364980510124
ko00380	Tryptophan metabolism	3/1255	50/7206	0.0370522749586
ko04973	Carbohydrate digestion and absorption	13/1255	42/7206	0.0378711892986
ko04666	Fc gamma R-mediated phagocytosis	30/1255	122/7206	0.0404084992423
ko00240	Pyrimidine metabolism	11/1255	110/7206	0.0417459752025
ko00310	Lysine degradation	6/1255	73/7206	0.0420969026678
ko04657	IL-17 signaling pathway	8/1255	87/7206	0.0453525155573
ko00562	Inositol phosphate metabolism	23/1255	89/7206	0.0474173319026
ko05416	Viral myocarditis	4/1255	55/7206	0.0484895498124
ko05321	Inflammatory bowel disease (IBD)	4/1255	56/7206	0.0493486299069