ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	147/840	423/7206	1.81159661597e-38
ko05033	Nicotine addiction	43/840	56/7206	1.17208409033e-29
ko04724	Glutamatergic synapse	71/840	152/7206	1.01997769508e-27
ko05032	Morphine addiction	56/840	110/7206	2.05489849634e-24
ko04727	GABAergic synapse	52/840	110/7206	7.53313852579e-21
ko04723	Retrograde endocannabinoid signaling	65/840	175/7206	7.08074182336e-19
ko04713	Circadian entrainment	55/840	136/7206	4.30873445912e-18
ko04728	Dopaminergic synapse	66/840	185/7206	4.39490251205e-18
ko04721	Synaptic vesicle cycle	40/840	80/7206	2.12117820429e-17
ko04024	cAMP signaling pathway	80/840	279/7206	3.0861414542e-15
ko04725	Cholinergic synapse	54/840	160/7206	7.83943270995e-14
ko04921	Oxytocin signaling pathway	61/840	209/7206	2.76767333293e-12
ko04911	Insulin secretion	42/840	117/7206	4.91814056491e-12
ko04020	Calcium signaling pathway	71/840	265/7206	6.06415554772e-12
ko04742	Taste transduction	28/840	61/7206	2.0671155737e-11
ko04726	Serotonergic synapse	45/840	137/7206	2.84421497524e-11
ko04261	Adrenergic signaling in cardiomyocytes	57/840	205/7206	1.30382508437e-10
ko05031	Amphetamine addiction	33/840	91/7206	7.24398906812e-10
ko04744	Phototransduction	19/840	36/7206	1.87926951033e-09
ko04720	Long-term potentiation	32/840	99/7206	3.33804631943e-08
ko05164	Influenza A	2/840	167/7206	4.95124083757e-07
ko03040	Spliceosome	1/840	145/7206	5.5835101564e-07
ko04970	Salivary secretion	29/840	95/7206	5.7901559537e-07
ko05203	Viral carcinogenesis	9/840	277/7206	7.35390995674e-07
ko05030	Cocaine addiction	24/840	73/7206	1.23721987756e-06
ko04925	Aldosterone synthesis and secretion	29/840	105/7206	7.5434617724e-06
ko05169	Epstein-Barr virus infection	6/840	206/7206	7.6447594439e-06
ko05162	Measles	1/840	120/7206	9.37714174713e-06
ko04010	MAPK signaling pathway	64/840	321/7206	1.0796646433e-05
ko04514	Cell adhesion molecules (CAMs)	33/840	130/7206	1.09450997341e-05
ko04260	Cardiac muscle contraction	27/840	98/7206	1.70394138855e-05
ko04971	Gastric acid secretion	27/840	98/7206	1.70394138855e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	23/840	79/7206	2.0195865597e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	22/840	74/7206	2.12070903354e-05
ko04060	Cytokine-cytokine receptor interaction	6/840	191/7206	3.10628277034e-05
ko04072	Phospholipase D signaling pathway	43/840	197/7206	3.81864911624e-05
ko04972	Pancreatic secretion	28/840	111/7206	6.47222448645e-05
ko04966	Collecting duct acid secretion	11/840	26/7206	7.44896977637e-05
ko04022	cGMP-PKG signaling pathway	45/840	216/7206	8.61710962655e-05
ko05168	Herpes simplex infection	6/840	182/7206	8.86819052398e-05
ko05322	Systemic lupus erythematosus	4/840	151/7206	9.30181216276e-05
ko04360	Axon guidance	47/840	233/7206	0.000155923513002
ko05161	Hepatitis B	6/840	173/7206	0.000172298806905
ko04110	Cell cycle	4/840	145/7206	0.000194213702041
ko05110	Vibrio cholerae infection	18/840	63/7206	0.000206254895662
ko04621	NOD-like receptor signaling pathway	5/840	157/7206	0.00021945409338
ko04730	Long-term depression	21/840	78/7206	0.00021946047806
ko04745	Phototransduction - fly	13/840	38/7206	0.000221958589412
ko05215	Prostate cancer	2/840	111/7206	0.000250532332942
ko04070	Phosphatidylinositol signaling system	27/840	112/7206	0.000261250177749
ko05205	Proteoglycans in cancer	14/840	271/7206	0.000317506600318
ko03013	RNA transport	6/840	166/7206	0.000337029097268
ko05166	HTLV-I infection	16/840	292/7206	0.000368374744807
ko04120	Ubiquitin mediated proteolysis	4/840	138/7206	0.000395530046866
ko03008	Ribosome biogenesis in eukaryotes	1/840	79/7206	0.00115893255722
ko04550	Signaling pathways regulating pluripotency of stem cells	7/840	165/7206	0.00128048703409
ko05414	Dilated cardiomyopathy	25/840	112/7206	0.00148340998686
ko04924	Renin secretion	20/840	86/7206	0.00199001995725
ko05200	Pathways in cancer	37/840	492/7206	0.00220001499326
ko04740	Olfactory transduction	19/840	80/7206	0.00225129279303
ko04141	Protein processing in endoplasmic reticulum	9/840	184/7206	0.0022780964692
ko04630	Jak-STAT signaling pathway	5/840	132/7206	0.00233016878548
ko04350	TGF-beta signaling pathway	3/840	103/7206	0.00282437413968
ko04510	Focal adhesion	14/840	240/7206	0.00285100205055
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/840	14/7206	0.00323548930498
ko04218	Cellular senescence	9/840	177/7206	0.00409837704439
ko04140	Autophagy - animal	8/840	164/7206	0.00428917517331
ko04964	Proximal tubule bicarbonate reclamation	9/840	29/7206	0.00438186733972
ko04540	Gap junction	26/840	128/7206	0.00483698991096
ko04064	NF-kappa B signaling pathway	3/840	96/7206	0.00570538861943
ko04210	Apoptosis	10/840	180/7206	0.00669484766239
ko04932	Non-alcoholic fatty liver disease (NAFLD)	10/840	182/7206	0.00673511585614
ko05410	Hypertrophic cardiomyopathy (HCM)	21/840	100/7206	0.00679419248788
ko04612	Antigen processing and presentation	2/840	77/7206	0.00699851884001
ko04610	Complement and coagulation cascades	2/840	79/7206	0.00713706393712
ko04961	Endocrine and other factor-regulated calcium reabsorption	14/840	59/7206	0.00734234282894
ko01521	EGFR tyrosine kinase inhibitor resistance	4/840	106/7206	0.00858344307536
ko04750	Inflammatory mediator regulation of TRP channels	24/840	122/7206	0.00960375419387
ko05140	Leishmaniasis	2/840	75/7206	0.0101671843139
ko01524	Platinum drug resistance	2/840	76/7206	0.0104065782997
ko05222	Small cell lung cancer	3/840	89/7206	0.011400887816
ko05418	Fluid shear stress and atherosclerosis	10/840	173/7206	0.0115287728566
ko05224	Breast cancer	10/840	174/7206	0.0115644805781
ko04915	Estrogen signaling pathway	25/840	131/7206	0.0125054793109
ko05120	Epithelial cell signaling in Helicobacter pylori infection	19/840	92/7206	0.0127744752666
ko04931	Insulin resistance	7/840	137/7206	0.0146246093529
ko05212	Pancreatic cancer	3/840	83/7206	0.0156130417598
ko05218	Melanoma	3/840	85/7206	0.0158740611529
ko05220	Chronic myeloid leukemia	3/840	85/7206	0.0158740611529
ko00480	Glutathione metabolism	1/840	55/7206	0.017986825711
ko00562	Inositol phosphate metabolism	18/840	89/7206	0.0184093778113
ko04068	FoxO signaling pathway	10/840	167/7206	0.0197104375076
ko04668	TNF signaling pathway	6/840	120/7206	0.0206045136114
ko05223	Non-small cell lung cancer	2/840	66/7206	0.0206535098943
ko04014	Ras signaling pathway	45/840	279/7206	0.0220313712979
ko05206	MicroRNAs in cancer	11/840	177/7206	0.0233301063616
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/840	15/7206	0.0235002743171
ko04910	Insulin signaling pathway	11/840	172/7206	0.0295990330548
ko04146	Peroxisome	4/840	89/7206	0.0301020754652
ko05145	Toxoplasmosis	7/840	126/7206	0.034161729227
ko00620	Pyruvate metabolism	1/840	46/7206	0.037844443596
ko03420	Nucleotide excision repair	1/840	46/7206	0.037844443596
ko00260	Glycine, serine and threonine metabolism	1/840	48/7206	0.0386934395136
ko04620	Toll-like receptor signaling pathway	5/840	100/7206	0.0395285799627
ko04657	IL-17 signaling pathway	4/840	87/7206	0.0416688422593
ko04212	Longevity regulating pathway - worm	4/840	87/7206	0.0416688422593
ko04214	Apoptosis - fly	3/840	72/7206	0.0423104705542
ko00330	Arginine and proline metabolism	2/840	61/7206	0.0423758126917
ko04115	p53 signaling pathway	3/840	74/7206	0.0428877921289
ko04217	Necroptosis	12/840	178/7206	0.0432456478731
ko05213	Endometrial cancer	2/840	62/7206	0.0433617417152
ko04330	Notch signaling pathway	2/840	62/7206	0.0433617417152
ko04150	mTOR signaling pathway	13/840	184/7206	0.0478718907902
ko04611	Platelet activation	11/840	163/7206	0.0478995340979