ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 156/978 423/7206 5.39071069077e-36 ko05033 Nicotine addiction 42/978 56/7206 1.47428608211e-25 ko04724 Glutamatergic synapse 72/978 152/7206 2.21971756428e-24 ko04728 Dopaminergic synapse 76/978 185/7206 6.0226274274e-21 ko05032 Morphine addiction 53/978 110/7206 1.21422955534e-18 ko04713 Circadian entrainment 58/978 136/7206 3.82941987528e-17 ko04721 Synaptic vesicle cycle 41/978 80/7206 6.66799107573e-16 ko04727 GABAergic synapse 49/978 110/7206 1.37484284034e-15 ko04024 cAMP signaling pathway 88/978 279/7206 3.04284622723e-15 ko04723 Retrograde endocannabinoid signaling 64/978 175/7206 7.36891959408e-15 ko04725 Cholinergic synapse 59/978 160/7206 5.66421865215e-14 ko04020 Calcium signaling pathway 80/978 265/7206 7.05722838864e-13 ko04726 Serotonergic synapse 49/978 137/7206 2.96022777796e-11 ko04921 Oxytocin signaling pathway 64/978 209/7206 9.17612997237e-11 ko04744 Phototransduction 21/978 36/7206 3.67612555347e-10 ko04911 Insulin secretion 42/978 117/7206 6.88003084589e-10 ko05031 Amphetamine addiction 35/978 91/7206 2.23273998129e-09 ko04261 Adrenergic signaling in cardiomyocytes 60/978 205/7206 2.4617488883e-09 ko03040 Spliceosome 1/978 145/7206 2.29943979162e-08 ko04720 Long-term potentiation 35/978 99/7206 2.89340354696e-08 ko04742 Taste transduction 25/978 61/7206 1.03360251562e-07 ko03010 Ribosome 1/978 129/7206 1.84128220748e-07 ko04070 Phosphatidylinositol signaling system 35/978 112/7206 9.76297254474e-07 ko04022 cGMP-PKG signaling pathway 54/978 216/7206 4.32713739041e-06 ko04970 Salivary secretion 30/978 95/7206 5.13961470918e-06 ko03013 RNA transport 5/978 166/7206 5.26811187336e-06 ko05030 Cocaine addiction 25/978 73/7206 5.35558897234e-06 ko05322 Systemic lupus erythematosus 4/978 151/7206 5.94818952811e-06 ko04514 Cell adhesion molecules (CAMs) 37/978 130/7206 6.56192219928e-06 ko04072 Phospholipase D signaling pathway 50/978 197/7206 6.78217109594e-06 ko05203 Viral carcinogenesis 15/978 277/7206 1.40922217086e-05 ko04120 Ubiquitin mediated proteolysis 4/978 138/7206 2.65497201372e-05 ko04730 Long-term depression 25/978 78/7206 3.07477259506e-05 ko04971 Gastric acid secretion 29/978 98/7206 3.41864595698e-05 ko04360 Axon guidance 54/978 233/7206 5.52726878303e-05 ko04966 Collecting duct acid secretion 12/978 26/7206 5.63537702637e-05 ko04745 Phototransduction - fly 15/978 38/7206 6.40468502443e-05 ko04621 NOD-like receptor signaling pathway 6/978 157/7206 7.74877240897e-05 ko04010 MAPK signaling pathway 69/978 321/7206 7.81135336751e-05 ko04014 Ras signaling pathway 61/978 279/7206 0.000111061146813 ko04925 Aldosterone synthesis and secretion 29/978 105/7206 0.00013136885506 ko05168 Herpes simplex infection 9/978 182/7206 0.000173488207758 ko04141 Protein processing in endoplasmic reticulum 9/978 184/7206 0.000175471042926 ko05014 Amyotrophic lateral sclerosis (ALS) 22/978 74/7206 0.000235062243048 ko04110 Cell cycle 6/978 145/7206 0.000309167745732 ko05169 Epstein-Barr virus infection 12/978 206/7206 0.000413755493467 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 22/978 79/7206 0.000719340962681 ko04740 Olfactory transduction 22/978 80/7206 0.000825991973111 ko05164 Influenza A 9/978 167/7206 0.000831636594276 ko04710 Circadian rhythm 14/978 43/7206 0.00111787995982 ko04626 Plant-pathogen interaction 8/978 18/7206 0.00138607536805 ko04260 Cardiac muscle contraction 25/978 98/7206 0.00149465702935 ko04060 Cytokine-cytokine receptor interaction 12/978 191/7206 0.001763532493 ko04972 Pancreatic secretion 27/978 111/7206 0.00190248756208 ko04612 Antigen processing and presentation 2/978 77/7206 0.00213832925502 ko04964 Proximal tubule bicarbonate reclamation 10/978 29/7206 0.00352073087639 ko04064 NF-kappa B signaling pathway 4/978 96/7206 0.00394004225075 ko00562 Inositol phosphate metabolism 22/978 89/7206 0.00440870517625 ko05110 Vibrio cholerae infection 17/978 63/7206 0.00454197801364 ko04924 Renin secretion 21/978 86/7206 0.00628861702277 ko04915 Estrogen signaling pathway 29/978 131/7206 0.00645027117569 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/978 14/7206 0.00699447421837 ko00965 Betalain biosynthesis 3/978 4/7206 0.00896085805727 ko05161 Hepatitis B 12/978 173/7206 0.00923939194017 ko05231 Choline metabolism in cancer 29/978 134/7206 0.0101801980938 ko05140 Leishmaniasis 3/978 75/7206 0.0103438611324 ko04750 Inflammatory mediator regulation of TRP channels 27/978 122/7206 0.0104770861017 ko04722 Neurotrophin signaling pathway 33/978 160/7206 0.0135465204133 ko05230 Central carbon metabolism in cancer 19/978 81/7206 0.0136644715439 ko03420 Nucleotide excision repair 1/978 46/7206 0.0164659611035 ko05410 Hypertrophic cardiomyopathy (HCM) 22/978 100/7206 0.0180973302533 ko05166 HTLV-I infection 26/978 292/7206 0.018108031796 ko05205 Proteoglycans in cancer 24/978 271/7206 0.0186533709657 ko04371 Apelin signaling pathway 35/978 177/7206 0.0191849891588 ko04960 Aldosterone-regulated sodium reabsorption 11/978 41/7206 0.0203700280474 ko04610 Complement and coagulation cascades 4/978 79/7206 0.0206933946595 ko05162 Measles 8/978 120/7206 0.0221227466448 ko04711 Circadian rhythm - fly 5/978 13/7206 0.0228879733899 ko03022 Basal transcription factors 1/978 44/7206 0.0247017694112 ko05414 Dilated cardiomyopathy 24/978 112/7206 0.0247559040707 ko04015 Rap1 signaling pathway 51/978 278/7206 0.0250651338174 ko05144 Malaria 1/978 45/7206 0.0255807824743 ko00280 Valine, leucine and isoleucine degradation 2/978 54/7206 0.0277661963361 ko05214 Glioma 18/978 79/7206 0.029673851797 ko04666 Fc gamma R-mediated phagocytosis 25/978 122/7206 0.0319312807178 ko04115 p53 signaling pathway 4/978 74/7206 0.0392559196705 ko00590 Arachidonic acid metabolism 2/978 52/7206 0.039984797708 ko04630 Jak-STAT signaling pathway 10/978 132/7206 0.040099474983 ko04622 RIG-I-like receptor signaling pathway 3/978 62/7206 0.0402417890354 ko00680 Methane metabolism 9/978 34/7206 0.0403921187635 ko04350 TGF-beta signaling pathway 7/978 103/7206 0.0420207404603 ko04923 Regulation of lipolysis in adipocytes 17/978 77/7206 0.0422809121746 ko05016 Huntington's disease 19/978 215/7206 0.0425286192949 ko04217 Necroptosis 15/978 178/7206 0.0453313249769 ko04071 Sphingolipid signaling pathway 31/978 162/7206 0.0474566161028 ko00240 Pyrimidine metabolism 8/978 110/7206 0.0497821973478