ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	157/873	423/7206	3.73640624808e-43
ko05033	Nicotine addiction	42/873	56/7206	1.40762098806e-27
ko04724	Glutamatergic synapse	71/873	152/7206	1.16822226659e-26
ko04721	Synaptic vesicle cycle	45/873	80/7206	1.75308323796e-21
ko05032	Morphine addiction	52/873	110/7206	4.42503024866e-20
ko04727	GABAergic synapse	51/873	110/7206	2.9960717061e-19
ko04728	Dopaminergic synapse	69/873	185/7206	3.75013594824e-19
ko04713	Circadian entrainment	57/873	136/7206	8.70589977866e-19
ko04723	Retrograde endocannabinoid signaling	64/873	175/7206	2.46786721579e-17
ko04024	cAMP signaling pathway	83/873	279/7206	8.07975831304e-16
ko04725	Cholinergic synapse	56/873	160/7206	2.39685504188e-14
ko04020	Calcium signaling pathway	73/873	265/7206	3.63428726996e-12
ko04744	Phototransduction	22/873	36/7206	3.8009558666e-12
ko04911	Insulin secretion	43/873	117/7206	4.04993575444e-12
ko04921	Oxytocin signaling pathway	62/873	209/7206	5.84056239433e-12
ko04726	Serotonergic synapse	47/873	137/7206	7.04252684614e-12
ko05031	Amphetamine addiction	35/873	91/7206	9.5950199436e-11
ko04261	Adrenergic signaling in cardiomyocytes	57/873	205/7206	6.28850870354e-10
ko04742	Taste transduction	26/873	61/7206	1.89426912237e-09
ko04720	Long-term potentiation	34/873	99/7206	5.7656884665e-09
ko05203	Viral carcinogenesis	8/873	277/7206	4.90551288127e-08
ko04966	Collecting duct acid secretion	14/873	26/7206	3.14063096968e-07
ko04970	Salivary secretion	30/873	95/7206	3.7789139089e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	25/873	74/7206	8.63335754628e-07
ko03040	Spliceosome	2/873	145/7206	2.17811147014e-06
ko05030	Cocaine addiction	24/873	73/7206	2.48332956056e-06
ko04022	cGMP-PKG signaling pathway	49/873	216/7206	1.02348984482e-05
ko05164	Influenza A	4/873	167/7206	1.0251419528e-05
ko05322	Systemic lupus erythematosus	3/873	151/7206	1.13101455551e-05
ko04060	Cytokine-cytokine receptor interaction	6/873	191/7206	1.48549157806e-05
ko04971	Gastric acid secretion	27/873	98/7206	2.75993646205e-05
ko04360	Axon guidance	50/873	233/7206	3.74471834878e-05
ko05168	Herpes simplex infection	6/873	182/7206	4.29458066074e-05
ko04010	MAPK signaling pathway	64/873	321/7206	4.83140681615e-05
ko05162	Measles	2/873	120/7206	5.14756073059e-05
ko04925	Aldosterone synthesis and secretion	28/873	105/7206	5.20412576181e-05
ko03013	RNA transport	5/873	166/7206	5.33062577108e-05
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/873	14/7206	6.89552717987e-05
ko04745	Phototransduction - fly	14/873	38/7206	7.715799171e-05
ko05110	Vibrio cholerae infection	19/873	63/7206	0.00010456045239
ko04260	Cardiac muscle contraction	26/873	98/7206	0.000113067782928
ko04141	Protein processing in endoplasmic reticulum	7/873	184/7206	0.000129808125333
ko04740	Olfactory transduction	22/873	80/7206	0.000171943523182
ko04120	Ubiquitin mediated proteolysis	4/873	138/7206	0.000183740311369
ko04514	Cell adhesion molecules (CAMs)	31/873	130/7206	0.000183952506186
ko05169	Epstein-Barr virus infection	9/873	206/7206	0.000193940326386
ko05205	Proteoglycans in cancer	15/873	271/7206	0.000289508450378
ko04730	Long-term depression	21/873	78/7206	0.000314427367575
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	21/873	79/7206	0.000367210062941
ko04621	NOD-like receptor signaling pathway	6/873	157/7206	0.000458601249484
ko04924	Renin secretion	22/873	86/7206	0.000616971200977
ko04626	Plant-pathogen interaction	8/873	18/7206	0.000642863111055
ko04610	Complement and coagulation cascades	1/873	79/7206	0.000752617328617
ko03008	Ribosome biogenesis in eukaryotes	1/873	79/7206	0.000752617328617
ko04540	Gap junction	29/873	128/7206	0.000840559831394
ko05166	HTLV-I infection	18/873	292/7206	0.000906883514968
ko04972	Pancreatic secretion	26/873	111/7206	0.00100047369188
ko04612	Antigen processing and presentation	1/873	77/7206	0.00116593701336
ko05161	Hepatitis B	8/873	173/7206	0.00127810804969
ko00310	Lysine degradation	1/873	73/7206	0.00169031270289
ko05414	Dilated cardiomyopathy	25/873	112/7206	0.0019525526162
ko04670	Leukocyte transendothelial migration	7/873	151/7206	0.00233341380446
ko04932	Non-alcoholic fatty liver disease (NAFLD)	10/873	182/7206	0.00377117154716
ko04630	Jak-STAT signaling pathway	6/873	132/7206	0.00438970432378
ko04070	Phosphatidylinositol signaling system	24/873	112/7206	0.0049349556225
ko04964	Proximal tubule bicarbonate reclamation	9/873	29/7206	0.00567591903911
ko04350	TGF-beta signaling pathway	4/873	103/7206	0.0058663404442
ko05140	Leishmaniasis	2/873	75/7206	0.00688270714987
ko01524	Platinum drug resistance	2/873	76/7206	0.0069971947927
ko04140	Autophagy - animal	9/873	164/7206	0.00721134782423
ko04146	Peroxisome	3/873	89/7206	0.00792670536328
ko05120	Epithelial cell signaling in Helicobacter pylori infection	20/873	92/7206	0.00895294290295
ko04214	Apoptosis - fly	2/873	72/7206	0.00996072501409
ko04110	Cell cycle	8/873	145/7206	0.00998786252857
ko04072	Phospholipase D signaling pathway	36/873	197/7206	0.0105044075972
ko03018	RNA degradation	3/873	84/7206	0.0109390256038
ko05220	Chronic myeloid leukemia	3/873	85/7206	0.0110601210083
ko04014	Ras signaling pathway	48/873	279/7206	0.01118524477
ko04064	NF-kappa B signaling pathway	4/873	96/7206	0.0113487278416
ko00240	Pyrimidine metabolism	5/873	110/7206	0.011459321294
ko05215	Prostate cancer	5/873	111/7206	0.0116704297488
ko00480	Glutathione metabolism	1/873	55/7206	0.0117627439434
ko05321	Inflammatory bowel disease (IBD)	1/873	56/7206	0.0119311800572
ko04668	TNF signaling pathway	6/873	120/7206	0.0153628067696
ko05010	Alzheimer's disease	36/873	202/7206	0.0157152216365
ko00590	Arachidonic acid metabolism	1/873	52/7206	0.0173885570985
ko00280	Valine, leucine and isoleucine degradation	1/873	54/7206	0.0184010125337
ko05222	Small cell lung cancer	4/873	89/7206	0.0216440047704
ko04068	FoxO signaling pathway	11/873	167/7206	0.0226634047868
ko04976	Bile secretion	17/873	80/7206	0.0229236203289
ko05202	Transcriptional misregulation in cancer	13/873	188/7206	0.0234381895179
ko05219	Bladder cancer	1/873	48/7206	0.025466610909
ko04510	Focal adhesion	18/873	240/7206	0.026292114656
ko04961	Endocrine and other factor-regulated calcium reabsorption	13/873	59/7206	0.0264280475689
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/873	15/7206	0.0273626564973
ko05146	Amoebiasis	5/873	99/7206	0.0287003118226
ko00330	Arginine and proline metabolism	2/873	61/7206	0.0290311622319
ko05323	Rheumatoid arthritis	18/873	89/7206	0.0313880184905
ko04910	Insulin signaling pathway	12/873	172/7206	0.0333144472349
ko05418	Fluid shear stress and atherosclerosis	12/873	173/7206	0.033319175124
ko04750	Inflammatory mediator regulation of TRP channels	23/873	122/7206	0.0342131065173
ko03022	Basal transcription factors	1/873	44/7206	0.0374329621124
ko00071	Fatty acid degradation	1/873	45/7206	0.0374468146225
ko04611	Platelet activation	11/873	163/7206	0.0378441083962
ko03420	Nucleotide excision repair	1/873	46/7206	0.0380409951837
ko05211	Renal cell carcinoma	5/873	96/7206	0.0389486911306
ko05212	Pancreatic cancer	4/873	83/7206	0.0408287550692
ko05410	Hypertrophic cardiomyopathy (HCM)	19/873	100/7206	0.0433060477276
ko04210	Apoptosis	13/873	180/7206	0.0480898016932