ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 40/487 191/7206 6.28561031526e-11 ko05340 Primary immunodeficiency 14/487 30/7206 1.83780036676e-09 ko04650 Natural killer cell mediated cytotoxicity 24/487 97/7206 1.57116272775e-08 ko05321 Inflammatory bowel disease (IBD) 17/487 56/7206 8.06052695819e-08 ko05164 Influenza A 31/487 167/7206 1.82022897385e-07 ko04380 Osteoclast differentiation 27/487 134/7206 2.05345945908e-07 ko05330 Allograft rejection 10/487 24/7206 1.50103425488e-06 ko04621 NOD-like receptor signaling pathway 28/487 157/7206 1.67412812348e-06 ko04660 T cell receptor signaling pathway 24/487 124/7206 2.10003449562e-06 ko05162 Measles 23/487 120/7206 4.07965397742e-06 ko04064 NF-kappa B signaling pathway 20/487 96/7206 4.63411153148e-06 ko05140 Leishmaniasis 17/487 75/7206 7.31967872277e-06 ko05145 Toxoplasmosis 23/487 126/7206 9.58500988786e-06 ko05320 Autoimmune thyroid disease 10/487 29/7206 1.12608878479e-05 ko04658 Th1 and Th2 cell differentiation 19/487 96/7206 1.74560620068e-05 ko05152 Tuberculosis 29/487 187/7206 2.07578364057e-05 ko04659 Th17 cell differentiation 20/487 106/7206 2.20788535221e-05 ko04217 Necroptosis 28/487 178/7206 2.35537538698e-05 ko00120 Primary bile acid biosynthesis 8/487 20/7206 2.50616671895e-05 ko04390 Hippo signaling pathway 1/487 188/7206 4.53704411644e-05 ko05150 Staphylococcus aureus infection 10/487 36/7206 9.29164720038e-05 ko05332 Graft-versus-host disease 7/487 18/7206 0.000101907100808 ko04672 Intestinal immune network for IgA production 10/487 37/7206 0.000119752155442 ko04612 Antigen processing and presentation 15/487 77/7206 0.00016065978008 ko05167 Kaposi's sarcoma-associated herpesvirus infection 27/487 191/7206 0.000206146778865 ko04662 B cell receptor signaling pathway 16/487 88/7206 0.000227816875009 ko04620 Toll-like receptor signaling pathway 17/487 100/7206 0.000338523576053 ko04062 Chemokine signaling pathway 27/487 201/7206 0.000512941589653 ko04630 Jak-STAT signaling pathway 20/487 132/7206 0.000597625091409 ko05310 Asthma 6/487 17/7206 0.000601304110414 ko03040 Spliceosome 1/487 145/7206 0.00067914594367 ko04137 Mitophagy - animal 14/487 82/7206 0.00106397554283 ko00592 alpha-Linolenic acid metabolism 6/487 19/7206 0.00117360333534 ko04668 TNF signaling pathway 18/487 120/7206 0.00128793133876 ko05133 Pertussis 14/487 87/7206 0.00191822857842 ko03010 Ribosome 1/487 129/7206 0.00215565526555 ko00590 Arachidonic acid metabolism 10/487 52/7206 0.00217653171168 ko04610 Complement and coagulation cascades 13/487 79/7206 0.00224182416576 ko05168 Herpes simplex infection 23/487 182/7206 0.0038300367834 ko04110 Cell cycle 2/487 145/7206 0.00411698924701 ko04940 Type I diabetes mellitus 7/487 32/7206 0.00471410786371 ko05160 Hepatitis C 20/487 153/7206 0.00473293076274 ko04068 FoxO signaling pathway 21/487 167/7206 0.00475461083469 ko04080 Neuroactive ligand-receptor interaction 15/487 423/7206 0.004962857062 ko04664 Fc epsilon RI signaling pathway 12/487 77/7206 0.00516019014363 ko05034 Alcoholism 6/487 238/7206 0.00536151258761 ko00140 Steroid hormone biosynthesis 8/487 41/7206 0.00540148827168 ko04623 Cytosolic DNA-sensing pathway 8/487 41/7206 0.00540148827168 ko04210 Apoptosis 22/487 180/7206 0.00615513080847 ko03013 RNA transport 3/487 166/7206 0.00690646402844 ko05142 Chagas disease (American trypanosomiasis) 17/487 130/7206 0.00741820138933 ko04622 RIG-I-like receptor signaling pathway 10/487 62/7206 0.00807544977846 ko05161 Hepatitis B 21/487 173/7206 0.00828358022323 ko05323 Rheumatoid arthritis 13/487 89/7206 0.00834438238322 ko04666 Fc gamma R-mediated phagocytosis 16/487 122/7206 0.00955486045453 ko05144 Malaria 8/487 45/7206 0.00961630481009 ko04350 TGF-beta signaling pathway 1/487 103/7206 0.00969469129714 ko04145 Phagosome 20/487 162/7206 0.0100198987494 ko04640 Hematopoietic cell lineage 10/487 64/7206 0.0100852130847 ko04611 Platelet activation 20/487 163/7206 0.0102521033626 ko00982 Drug metabolism - cytochrome P450 7/487 37/7206 0.0107674641273 ko04146 Peroxisome 12/487 89/7206 0.0179221564913 ko03015 mRNA surveillance pathway 1/487 93/7206 0.0205018491393 ko00051 Fructose and mannose metabolism 7/487 42/7206 0.0211092689318 ko00350 Tyrosine metabolism 6/487 33/7206 0.021440325858 ko05132 Salmonella infection 13/487 98/7206 0.0224124213331 ko04710 Circadian rhythm 7/487 43/7206 0.0237980335748 ko00360 Phenylalanine metabolism 4/487 17/7206 0.0242160195278 ko04310 Wnt signaling pathway 5/487 181/7206 0.0242682579495 ko05131 Shigellosis 11/487 82/7206 0.024478103551 ko00950 Isoquinoline alkaloid biosynthesis 3/487 10/7206 0.0257441292296 ko05134 Legionellosis 10/487 74/7206 0.0317513180332 ko04723 Retrograde endocannabinoid signaling 5/487 175/7206 0.0324975692126 ko04670 Leukocyte transendothelial migration 17/487 151/7206 0.0325675842309 ko04514 Cell adhesion molecules (CAMs) 15/487 130/7206 0.034427717774 ko01524 Platinum drug resistance 10/487 76/7206 0.0357370857709 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/487 5/7206 0.0397522647987 ko00281 Geraniol degradation 2/487 5/7206 0.0397522647987 ko05146 Amoebiasis 12/487 99/7206 0.0417795286808 ko05224 Breast cancer 5/487 174/7206 0.0446085455678 ko03320 PPAR signaling pathway 9/487 69/7206 0.0493128104924