ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 46/317 191/7206 2.44926864944e-22 ko04380 Osteoclast differentiation 33/317 134/7206 1.48763218964e-16 ko05321 Inflammatory bowel disease (IBD) 19/317 56/7206 9.48991866616e-13 ko05162 Measles 27/317 120/7206 1.02738196182e-12 ko05140 Leishmaniasis 21/317 75/7206 4.07602187659e-12 ko05164 Influenza A 31/317 167/7206 4.69926893428e-12 ko05340 Primary immunodeficiency 14/317 30/7206 5.89008498966e-12 ko05168 Herpes simplex infection 32/317 182/7206 9.56409125112e-12 ko05145 Toxoplasmosis 26/317 126/7206 2.25770830752e-11 ko04621 NOD-like receptor signaling pathway 29/317 157/7206 2.71436232955e-11 ko04064 NF-kappa B signaling pathway 22/317 96/7206 9.55065788009e-11 ko04650 Natural killer cell mediated cytotoxicity 22/317 97/7206 1.18654122351e-10 ko04630 Jak-STAT signaling pathway 25/317 132/7206 3.88499570149e-10 ko04659 Th17 cell differentiation 22/317 106/7206 7.37032141692e-10 ko04620 Toll-like receptor signaling pathway 21/317 100/7206 1.44760555832e-09 ko05150 Staphylococcus aureus infection 13/317 36/7206 1.67651249912e-09 ko04658 Th1 and Th2 cell differentiation 20/317 96/7206 4.17631441325e-09 ko05152 Tuberculosis 28/317 187/7206 8.94031618377e-09 ko04640 Hematopoietic cell lineage 16/317 64/7206 9.66674415504e-09 ko04612 Antigen processing and presentation 17/317 77/7206 2.50549658572e-08 ko05330 Allograft rejection 10/317 24/7206 2.66969645373e-08 ko04217 Necroptosis 26/317 178/7206 5.23655926303e-08 ko04660 T cell receptor signaling pathway 21/317 124/7206 8.03530976102e-08 ko05310 Asthma 8/317 17/7206 2.20745863095e-07 ko05167 Kaposi's sarcoma-associated herpesvirus infection 26/317 191/7206 2.22600660883e-07 ko04672 Intestinal immune network for IgA production 11/317 37/7206 3.07643692776e-07 ko04622 RIG-I-like receptor signaling pathway 14/317 62/7206 3.27195354843e-07 ko04062 Chemokine signaling pathway 26/317 201/7206 6.15700653309e-07 ko04662 B cell receptor signaling pathway 16/317 88/7206 1.09378938861e-06 ko05161 Hepatitis B 23/317 173/7206 1.73471336605e-06 ko05320 Autoimmune thyroid disease 9/317 29/7206 2.53020703384e-06 ko05332 Graft-versus-host disease 7/317 18/7206 6.2460649865e-06 ko04668 TNF signaling pathway 17/317 120/7206 1.72692116089e-05 ko05323 Rheumatoid arthritis 14/317 89/7206 2.92410387663e-05 ko04610 Complement and coagulation cascades 13/317 79/7206 3.45252656305e-05 ko04623 Cytosolic DNA-sensing pathway 9/317 41/7206 5.54593295785e-05 ko04145 Phagosome 19/317 162/7206 8.26386190054e-05 ko04611 Platelet activation 19/317 163/7206 8.98624458962e-05 ko04657 IL-17 signaling pathway 13/317 87/7206 9.74482578125e-05 ko05133 Pertussis 13/317 87/7206 9.74482578125e-05 ko04664 Fc epsilon RI signaling pathway 12/317 77/7206 0.000119253536119 ko05144 Malaria 9/317 45/7206 0.000120093855902 ko05160 Hepatitis C 18/317 153/7206 0.000122035900749 ko05142 Chagas disease (American trypanosomiasis) 16/317 130/7206 0.000170998481543 ko04940 Type I diabetes mellitus 7/317 32/7206 0.000387861668415 ko04666 Fc gamma R-mediated phagocytosis 14/317 122/7206 0.000883051381074 ko00120 Primary bile acid biosynthesis 5/317 20/7206 0.00143296471264 ko05416 Viral myocarditis 8/317 55/7206 0.00256596782013 ko05166 HTLV-I infection 24/317 292/7206 0.0030680426842 ko05034 Alcoholism 2/317 238/7206 0.00318037672561 ko05132 Salmonella infection 11/317 98/7206 0.00367219737619 ko05418 Fluid shear stress and atherosclerosis 16/317 173/7206 0.00420151199778 ko05134 Legionellosis 9/317 74/7206 0.00489468921704 ko04310 Wnt signaling pathway 1/317 181/7206 0.00496931608234 ko05169 Epstein-Barr virus infection 18/317 206/7206 0.00497397188377 ko04728 Dopaminergic synapse 1/317 185/7206 0.0052279476598 ko04514 Cell adhesion molecules (CAMs) 13/317 130/7206 0.00729648708888 ko04723 Retrograde endocannabinoid signaling 1/317 175/7206 0.00747634246048 ko04670 Leukocyte transendothelial migration 14/317 151/7206 0.00752916688339 ko04210 Apoptosis 16/317 180/7206 0.00822678783297 ko05131 Shigellosis 9/317 82/7206 0.00955902220339 ko05146 Amoebiasis 10/317 99/7206 0.0114003729284 ko05012 Parkinson's disease 1/317 155/7206 0.0153181088905 ko04390 Hippo signaling pathway 2/317 188/7206 0.0177597366486 ko03040 Spliceosome 1/317 145/7206 0.0219344395221 ko00590 Arachidonic acid metabolism 6/317 52/7206 0.0256400930821 ko05016 Huntington's disease 3/317 215/7206 0.0263634146205 ko03050 Proteasome 6/317 54/7206 0.0302536647827 ko00051 Fructose and mannose metabolism 5/317 42/7206 0.0358062926312 ko04144 Endocytosis 23/317 342/7206 0.0412665228722 ko00190 Oxidative phosphorylation 1/317 127/7206 0.0455348967195 ko01200 Carbon metabolism 1/317 128/7206 0.0459544918934 ko04922 Glucagon signaling pathway 1/317 128/7206 0.0459544918934 ko04360 Axon guidance 4/317 233/7206 0.0486279024253 ko01524 Platinum drug resistance 7/317 76/7206 0.048873309353