ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 118/723 423/7206 4.12006893657e-27 ko04724 Glutamatergic synapse 58/723 152/7206 8.66587805456e-21 ko05033 Nicotine addiction 30/723 56/7206 3.30393246986e-16 ko04727 GABAergic synapse 40/723 110/7206 7.31414890627e-14 ko05032 Morphine addiction 39/723 110/7206 3.89838870176e-13 ko04728 Dopaminergic synapse 53/723 185/7206 4.80951961783e-13 ko04725 Cholinergic synapse 48/723 160/7206 9.77848136166e-13 ko04713 Circadian entrainment 42/723 136/7206 9.38987256617e-12 ko04723 Retrograde endocannabinoid signaling 47/723 175/7206 1.25498815649e-10 ko04911 Insulin secretion 33/723 117/7206 2.07562367282e-08 ko04721 Synaptic vesicle cycle 26/723 80/7206 2.79002927791e-08 ko04514 Cell adhesion molecules (CAMs) 35/723 130/7206 2.8705306627e-08 ko05031 Amphetamine addiction 27/723 91/7206 1.29147173953e-07 ko04740 Olfactory transduction 24/723 80/7206 5.15588475469e-07 ko04974 Protein digestion and absorption 26/723 96/7206 1.55704801423e-06 ko04726 Serotonergic synapse 33/723 137/7206 1.62713346765e-06 ko04744 Phototransduction 14/723 36/7206 4.28068172646e-06 ko05030 Cocaine addiction 21/723 73/7206 5.58366832894e-06 ko03040 Spliceosome 1/723 145/7206 7.79802798761e-06 ko04024 cAMP signaling pathway 51/723 279/7206 1.61729305874e-05 ko04742 Taste transduction 18/723 61/7206 1.7672216534e-05 ko04020 Calcium signaling pathway 49/723 265/7206 2.33078319018e-05 ko05322 Systemic lupus erythematosus 2/723 151/7206 2.75097301277e-05 ko05164 Influenza A 3/723 167/7206 3.94347150507e-05 ko05016 Huntington's disease 6/723 215/7206 7.01887472928e-05 ko05162 Measles 1/723 120/7206 8.15567564656e-05 ko04120 Ubiquitin mediated proteolysis 2/723 138/7206 8.67805849263e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 19/723 74/7206 8.77993604189e-05 ko04970 Salivary secretion 22/723 95/7206 0.000173905300475 ko03013 RNA transport 4/723 166/7206 0.000210896687518 ko05203 Viral carcinogenesis 11/723 277/7206 0.000214044463268 ko05168 Herpes simplex infection 5/723 182/7206 0.000242951869178 ko04971 Gastric acid secretion 22/723 98/7206 0.000245180848744 ko04720 Long-term potentiation 21/723 99/7206 0.000991468094324 ko04921 Oxytocin signaling pathway 36/723 209/7206 0.00100030024151 ko04932 Non-alcoholic fatty liver disease (NAFLD) 6/723 182/7206 0.001002315353 ko00350 Tyrosine metabolism 10/723 33/7206 0.00105226823883 ko04010 MAPK signaling pathway 50/723 321/7206 0.00158394260398 ko04925 Aldosterone synthesis and secretion 21/723 105/7206 0.00166531176544 ko04916 Melanogenesis 26/723 142/7206 0.00260912375834 ko04261 Adrenergic signaling in cardiomyocytes 34/723 205/7206 0.0029667184463 ko00564 Glycerophospholipid metabolism 2/723 99/7206 0.00364067931327 ko04610 Complement and coagulation cascades 1/723 79/7206 0.00402506377546 ko03008 Ribosome biogenesis in eukaryotes 1/723 79/7206 0.00402506377546 ko04060 Cytokine-cytokine receptor interaction 8/723 191/7206 0.00460103314391 ko04360 Axon guidance 37/723 233/7206 0.00520239462427 ko04621 NOD-like receptor signaling pathway 6/723 157/7206 0.00662011064135 ko04961 Endocrine and other factor-regulated calcium reabsorption 13/723 59/7206 0.00675105288419 ko04976 Bile secretion 16/723 80/7206 0.00724780460966 ko04214 Apoptosis - fly 1/723 72/7206 0.00885775831677 ko04014 Ras signaling pathway 41/723 279/7206 0.0108953189883 ko04745 Phototransduction - fly 9/723 38/7206 0.0110985891294 ko04140 Autophagy - animal 7/723 164/7206 0.0116468893046 ko04137 Mitophagy - animal 2/723 82/7206 0.015258383814 ko04972 Pancreatic secretion 19/723 111/7206 0.0168099411363 ko04141 Protein processing in endoplasmic reticulum 9/723 184/7206 0.0173912782068 ko00561 Glycerolipid metabolism 1/723 63/7206 0.0186809025316 ko04612 Antigen processing and presentation 2/723 77/7206 0.0216802811018 ko04218 Cellular senescence 9/723 177/7206 0.0224297514671 ko04217 Necroptosis 9/723 178/7206 0.0224494159238 ko04260 Cardiac muscle contraction 17/723 98/7206 0.0255500116225 ko00330 Arginine and proline metabolism 1/723 61/7206 0.0286182066432 ko00310 Lysine degradation 2/723 73/7206 0.0307440897894 ko04146 Peroxisome 3/723 89/7206 0.031915471344 ko04310 Wnt signaling pathway 27/723 181/7206 0.0326286941956 ko04512 ECM-receptor interaction 14/723 79/7206 0.0352101324511 ko04630 Jak-STAT signaling pathway 6/723 132/7206 0.0388053423365 ko00520 Amino sugar and nucleotide sugar metabolism 1/723 55/7206 0.039841761575 ko03320 PPAR signaling pathway 2/723 69/7206 0.0434582686172 ko03018 RNA degradation 3/723 84/7206 0.0440160057189